The A Comparison Study of 0.3% Ofloxacin Plus 1% Prednisolone Acetate (OFX/PRED) and 0.3% Ofloxacin (OFX) Alone for Treatment of Acute Otitis Externa
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Abstract
Objective: To compare the effectiveness of 0.3% ofloxacin plus 1% prednisolone acetate
(OFX/PRED) and 0.3% ofloxacin (OFX) alone for the treatment of acute otitis externa
Materials and methods: Forty-two adult patients with acute otitis externa (20 cases in
OFX/PRED and 22 cases in OFX) were enrolled in a prospective, double-blinded, randomized
controlled trial. Edema resolution, pain score, clinical symptom score, and any adverse events
were recorded during the treatment.
Results: Our results showed that the difference of edema resolution between both groups at
7-day post treatment were not statistically significant (p-value = 0.56). Moreover, the change
of pain score and clinical symptom score were not significantly different (p-value = 0.22 and
0.88). No serious adverse events occurred in both groups.
Conclusion: Both OFX/ PRED and OFX showed equal effectiveness in acute otitis externa
treatment, in terms of reducing edema, pain score and clinical symptom score. Therefore, it
may be unnecessary to combine ofloxacin with steroid for the treatment of acute otitis
externa.
Keywords: Acute otitis externa, ofloxacin, prednisolone acetate
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ต้นฉบับที่ส่งมาพิจารณายังวารสารหู คอ จมูก และใบหน้า จะต้องไม่อยู่ในการพิจารณาของวารสารอื่น ในขณะเดียวกันต้นฉบับที่จะส่งมาจะผ่านการอ่านโดยผู้ทรงคุณวุฒิ หากมีการวิจารณ์หรือแก้ไขจะส่งกลับไปให้ผู้เขียนตรวจสอบแก้ไขอีกครั้ง ต้นฉบับที่ผ่านการพิจารณาให้ลงตีพิมพ์ถือเป็นสมบัติของวารสารหู คอ จมูกและใบหน้า ไม่อาจนำไปลงตีพิมพ์ที่อื่นโดยไม่ได้รับอนุญาต
ตารางแผนภูมิ รูปภาพ หรือข้อความเกิน 100 คำที่คัดลอกมาจากบทความของผู้อื่น จะต้องมีใบยินยอมจากผู้เขียนหรือผู้ทรงลิขสิทธิ์นั้นๆ และใหร้ะบุกำกับไว้ในเนื้อเรื่องด้วย
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