Clinical and Polysomnographic Parameters of Children with Sleep Disordered Breathing: Comparison between Surgical and Non-surgical Candidates

Main Article Content

Thananard Kriengkraikasem
Archwin Tanphaichitr
Sarin Rungmanee
Chawanont Pimolsri
Wattanachai Chotinaiwattarakul
Wish Banhiran

Abstract

Abstract



Objective: To compare clinical and polysomnography (PSG) parameters in children with sleep-
disordered breathing (SDB) that influence the treatment decision between surgical and non- surgical
treatment.


Study design: Retrospective study.



Material and methods: Patients aged 2–15 years with SDB who underwent PSG were recruited. Clinical
and PSG parameters were compared between surgical and non-surgical candidates.



Results: Three hundred and eighty patients were included, with a mean age of 8.72 ± 3.78 years. In
terms of sleep architecture, the surgical group had a significant increase in total sleep time,
sleep stages N3, and REM (P<0.05), but had a significant reduction in sleep stage N2 (P<0.05)
compared to the non-surgical group. In terms of respiratory parameters, there was a significant
increase in the AHI, obstructive AHI, apnea index, hypopnea index, the longest time of apnea and
hypopnea, mean oxygen saturation, oxygen desaturation index and the total arousal index in surgical
group compared to non-surgical group (P<0.05). Multivariate analysis demonstrated age 2-5 years,
tonsil size 3+ and 4+, and obstructive AHI ≥ 5 events/h were significant risk factors for surgical
treatment (P<0.05).



Conclusion: Both clinical and PSG parameters should be taken into consideration in the treatment
decision for pediatric patients with SDB, especially age, tonsil size, and obstructive AHI. A
prospective multicenter study with a larger sample size to create comprehensive care for patients
with SDB is needed.


Keyword
Pediatric, Polysomnography, Sleep-disordered breathing, Obstructive sleep apnea,
Adenotonsillectomy, Surgical treatment

Article Details

How to Cite
Kriengkraikasem, T., Tanphaichitr, A. ., Rungmanee, S. ., Pimolsri, C. ., Chotinaiwattarakul, W. ., & Banhiran, W. . (2023). Clinical and Polysomnographic Parameters of Children with Sleep Disordered Breathing: Comparison between Surgical and Non-surgical Candidates. Thai Journal of Otolaryngology Head and Neck Surgery, 24(1). Retrieved from https://he02.tci-thaijo.org/index.php/rcotJ/article/view/261239
Section
Reseach Articles

References

References

Wakefield TL LD, Ishman SL. Sleep Apnea and Sleep Disorders. Cummings Otolaryngology–Head & Neck Surgery. 6th Philadelphia, PA: Saunders Elsevier2015. p. 252‐72.

Marcus CL, Brooks LJ, Draper KA, et al. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics. 2012;130(3):576-84.

Anuntaseree W, Rookkapan K, Kuasirikul S, et al. Snoring and obstructive sleep apnea in Thai school-age children: prevalence and predisposing factors. Pediatr Pulmonol. 2001;32(3):222-7.

Sritipsukho P KP, Satdhabudha A, Tanakitivirul N. Sleep Disordered Breathing in Thai Primary School Children. J Med Assoc Thai 2017.100(6):175.

Veeravigrom M, Desudchit T. Prevalence of Sleep Disorders in Thai Children. Indian J Pediatr. 2016;83(11):1237-41.

Halbower AC, Degaonkar M, Barker PB, et al. Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury. PLoS Med. 2006;3(8):e301.

Castronovo V, Zucconi M, Nosetti L, et al. Prevalence of habitual snoring and sleep-disordered breathing in preschool-aged children in an Italian community. J Pediatr. 2003;142(4):377-82.

Xu Z-f, Shen K-l. The epidemiology of snoring and obstructive sleep apnea/hypopnea in Mainland China. Biol Rhythm Res. 2010;41(3):225-33.

Bitners AC, Arens R. Evaluation and Management of Children with Obstructive Sleep Apnea Syndrome. Lung. 2020;198(2):257-70.

Mitchell RB, Archer SM, Ishman SL, et al. Clinical Practice Guideline: Tonsillectomy in Children (Update). Otolaryngol Head Neck Surg. 2019;160(1_suppl):S1-s42.

Roland PS, Rosenfeld RM, Brooks LJ, et al. Clinical practice guideline: Polysomnography for sleep-disordered breathing prior to tonsillectomy in children. Otolaryngol Head Neck Surg. 2011;145(1 Suppl):S1-15.

Sulman CG. Pediatric sleep surgery. Frontiers in pediatrics. 2014;2:51.

Erickson BK, Larson DR, St Sauver JL, et al. Changes in incidence and indications of tonsillectomy and adenotonsillectomy, 1970-2005. Otolaryngol Head Neck Surg. 2009;140(6):894-901.

Zhao G, Li Y, Wang X, et al. The predictive value of polysomnography combined with quality of life for treatment decision of children with habitual snoring related to adenotonsillar hypertrophy. Eur Arch Otorhinolaryngol. 2018;275(6):1579-86.

Garetz SL, Mitchell RB, Parker PD, et al. Quality of life and obstructive sleep apnea symptoms after pediatric adenotonsillectomy. Pediatrics. 2015;135(2):e477-86.

Marcus CL, Moore RH, Rosen CL, et al. A randomized trial of adenotonsillectomy for childhood sleep apnea. N Engl J Med. 2013;368(25):2366-76.

Chervin RD, Ellenberg SS, Hou X, et al. Prognosis for Spontaneous Resolution of OSA in Children. Chest. 2015;148(5):1204-13.

Weatherly RA, Mai EF, Ruzicka DL, et al. Identification and evaluation of obstructive sleep apnea prior to adenotonsillectomy in children: a survey of practice patterns. Sleep Med. 2003;4(4):297-307.

Liu JF, Tsai CM, Su MC, et al. Application of desaturation index in post-surgery follow-up in children with obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. 2017;274(1):375-82.

Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med. 2012;8(5):597-619.

Montgomery-Downs HE, O'Brien LM, Holbrook CR, et al. Snoring and sleep-disordered breathing in young children: subjective and objective correlates. Sleep. 2004;27(1):87-94.

de Onis M, Onyango AW, Borghi E, et al. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ. 2007;85(9):660-7.

Brodsky L. Modern assessment of tonsils and adenoids. Pediatr Clin North Am. 1989;36(6):1551-69.

Bhattacharjee R, Kheirandish-Gozal L, Spruyt K, et al. Adenotonsillectomy outcomes in treatment of obstructive sleep apnea in children: a multicenter retrospective study. Am J Respir Crit Care Med. 2010;182(5):676-83.

Gates GA. Sizing Up the Adenoid. Archives of Otolaryngology–Head & Neck Surgery. 1996;122(3):239-40.

Guo Y, Pan Z, Gao F, et al. Characteristics and risk factors of children with sleep-disordered breathing in Wuxi, China. BMC Pediatr. 2020;20(1):310.

Kljajic Z, Glumac S, Deutsch JA, et al. Feasibility study of determining a risk assessment model for obstructive sleep apnea in children based on local findings and clinical indicators. Int J Pediatr Otorhinolaryngol. 2020;135:110081.

Hunter SJ, Gozal D, Smith DL, et al. Effect of Sleep-disordered Breathing Severity on Cognitive Performance Measures in a Large Community Cohort of Young School-aged Children. Am J Respir Crit Care Med. 2016;194(6):739-47.

Amin R, Somers VK, McConnell K, et al. Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing. Hypertension. 2008;51(1):84-91.

Lau EY, Choi EW, Lai ES, et al. Working memory impairment and its associated sleep-related respiratory parameters in children with obstructive sleep apnea. Sleep Med. 2015;16(9):1109-15.

Goh DY, Galster P, Marcus CL. Sleep architecture and respiratory disturbances in children with obstructive sleep apnea. Am J Respir Crit Care Med. 2000;162(2 Pt 1):682-6.

Saraç S, Afsar GC. Effect of mean apnea-hypopnea duration in patients with obstructive sleep apnea on clinical and polysomnography parameter. Sleep & breathing = Schlaf & Atmung. 2020;24(1):77-81.

Tsai CM, Kang CH, Su MC, et al. Usefulness of desaturation index for the assessment of obstructive sleep apnea syndrome in children. Int J Pediatr Otorhinolaryngol. 2013;77(8):1286-90.