The Efficacy and Safety of Prasaprohyai Remedy, a Thai traditional remedy compared to Loratadine in Allergic Rhinitis Patients Efficacy and Safety of Prasaprohyai Remedy, a Thai traditional remedy compared to Loratadine in Allergic Rhinitis Patients
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Abstract
ABSTRACT
Background: Prasaprohyai remedy (PSPR) has been used to treat common cold and fever, but there is no report of efficacy and safety. Thus, the objectives of this study are to compare the efficacy and safety of PSPR powder and Loratadine in allergic rhinitis patients.
Methods: The study design was a double-blind, randomized controlled trial. Sixty-three allergic rhinitis volunteers were divided into two random groups. One took PSPR remedy powder at a dose of 1,000 mg three times a day before meals, and the other took Loratadine at a dose of 10 mg once daily before meals and received a placebo to maintain double-blind conditions for six weeks. All volunteers were followed up in the third week and the sixth week to evaluate the efficacy and safety of the medicines.
Conclusion: PSPR increased the minimal cross section area (MCA) in the sixth week. PSPR and Loratadine were able to relieve the symptoms of sneezing, running nose, stuffy nose, itchy nose, total nasal symptoms, and to raise quality of life (p < 0.05). A side effect of PSPR is eructate (23.3%) and a side effect of Loratadine is drowsiness (13.3 %). After taking PSPR, there was no adverse effect on either renal or liver function. Then PSPR appears to be as safe and effective as Loratadine treatment and could be a potential choice for the treatment of allergic rhinitis.
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ต้นฉบับที่ส่งมาพิจารณายังวารสารหู คอ จมูก และใบหน้า จะต้องไม่อยู่ในการพิจารณาของวารสารอื่น ในขณะเดียวกันต้นฉบับที่จะส่งมาจะผ่านการอ่านโดยผู้ทรงคุณวุฒิ หากมีการวิจารณ์หรือแก้ไขจะส่งกลับไปให้ผู้เขียนตรวจสอบแก้ไขอีกครั้ง ต้นฉบับที่ผ่านการพิจารณาให้ลงตีพิมพ์ถือเป็นสมบัติของวารสารหู คอ จมูกและใบหน้า ไม่อาจนำไปลงตีพิมพ์ที่อื่นโดยไม่ได้รับอนุญาต
ตารางแผนภูมิ รูปภาพ หรือข้อความเกิน 100 คำที่คัดลอกมาจากบทความของผู้อื่น จะต้องมีใบยินยอมจากผู้เขียนหรือผู้ทรงลิขสิทธิ์นั้นๆ และใหร้ะบุกำกับไว้ในเนื้อเรื่องด้วย
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