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Pes anserine bursitis is a cause of the medial knee pain. The repetitive friction and stress over the anserine during overuse of knee joint led to an inflammation of the anserine bursa. The common symptoms include proximal medial tibia pain and swelling. Nowadays, various treatments for Pes anserine bursitis have been suggested such as local injection with corticosteroid and anesthetics, non-steroidal anti-inflammatory drugs (NSAIDs) and knee orthosis. However, those treatments may not appropriate in some conditions and may cause side effects after long-term treatment. Extracorporeal shock wave therapy (ESWT) is recently considered as one of the most widely-used physical therapy treatment. Due to the physiological mechanisms of ESWT emphasize on promoting healing process and enhance tissue regeneration. Moreover, ESWT is non-invasive, efficacious, convenient and cost-effective treatment.