Thai Traditional Herbal Medicines Used to Treat Fever in Tamra Kanphaet Thaidoem (Phaetthayasat Songkhro Chabap Anurak) Volume 1 an analysis based on Thai traditional pharmacy and their scientific evidence

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Natchagorn Lumlerdkij
Watcharinporn Prompituck
Phiyaon Seeloopmorkk
Suksalin Booranasubkajorn
Suveerawan Limsuvan
Pravit Akarasereenont
U-tain Wongsathit


Objectives: (1) To study herbal medicines used to treat fever in the scriptures (2) to analyze the relationship between the number of crude drugs and the number of scriptures and (3) to review scientific evidence related to antipyretic property of the herbs

Methods: Herbal recipes and herbs mentioned for the treatment of fever in Tamra Kanphaet Thaidoem (Phaetthayasat Songkhro Chabap Anurak) Volume 1 were listed. The names of crude drugs were checked by experts in Thai language and experts in Thai traditional pharmacy. Then the literature search was performed using PubMed database to find scientific evidence related to antipyretic property on the crude drugs.

Results: Nine out of thirteen scriptures mentioned remedies for fever. Khamphi Sapphakhunya contained the highest number of herbal recipes (54 recipes), followed by Khamphi Prathomchinda (52 recipes) and Khamphi That Wiworn (47 recipes), respectively. The fever remedies included 70 single herbs and 187 herbal recipes. Twenty-seven herbs were used in more than 18 recipes. The literature search provided evidence related to the traditional uses of 17 herbs.

Conclusion: Our findings show that fever is an important symptom in Thai traditional medicine. The use of herbal mixtures is more common than single herbs. The lack of scientific evidence suggests that there is a crucial need for research on these remedies in order to provide the rational uses.


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Lumlerdkij N, Prompituck W, Seeloopmorkk P, Booranasubkajorn S, Limsuvan S, Akarasereenont P, Wongsathit U- tain. Thai Traditional Herbal Medicines Used to Treat Fever in Tamra Kanphaet Thaidoem (Phaetthayasat Songkhro Chabap Anurak) Volume 1: an analysis based on Thai traditional pharmacy and their scientific evidence. Siriraj Med Bull [Internet]. 2020 Oct. 1 [cited 2023 Nov. 30];13(4):232-46. Available from:
Original Article


1. Foundation for the Promotion of Thai Traditional Medicine, Ayurved Thamrong School Center of Applied Thai Traditional Medicine, editors. Tamra Kanphaet Thaidoem (Phaetthayasat Songkhro Chabap Anurak) Volume 1. 2 ed. Bangkok: Supphawanit Kanphim; 2007.
2. The Editors and Editorial Board. “Rules of 5” [Editorial]. J Ethnopharmacol 2006;103(3):309-10.
3. Ghasemzadeh A, Jaafar HZ, Ashkani S, Rahmat A, Juraimi AS, Puteh A, et al. Variation in secondary metabolite production as well as antioxidant and antibacterial activities of Zingiber zerumbet (L.) at different stages of growth. BMC Complement Altern Med 2016;16:104.
4. Tzeng TF, Hong TY, Tzeng YC, Liou SS, Liu IM. Consumption of Polyphenol-Rich Zingiber zerumbet rhizome extracts protects against the breakdown of the blood-retinal barrier and retinal inflammation induced by diabetes. Nutrients 2015;7(9):7821-41.
5. Kantibiswas T, Marjit B, Maity LN. Effect of Picrorhiza kurroa Benth in acute inflammation. Anc Sci Life 1996;16(1):11-4.
6. Kumar R, Gupta YK, Singh S, Raj A. Anti-inflammatory Effect of Picrorhiza kurroa in experimental models of inflammation. Planta Med 2016;82(16):1403-9.
7. Rajkumar V, Guha G, Kumar RA. Antioxidant and anti-neoplastic activities of Picrorhiza kurroa extracts. Food Chem Toxicol 2011;49(2):363-9.
8. Kim WS, Choi WJ, Lee S, Kim WJ, Lee DC, Sohn UD, et al. Anti-inflammatory, antioxidant and antimicrobial effects of artemisinin extracts from Artemisia annua L. Korean J Physio Pha 2015;19(1):21-7.
9. Chao WW, Hong YH, Chen ML, Lin BF. Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation. J Ethnopharmacol 2010;129(2):244-9.
10. Saw CL, Wu Q, Su ZY, Wang H, Yang Y, Xu X, et al. Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation. Biopharm Drug Dispos 2013;34(6):303-11.
11. Hua YL, Ji P, Xue ZY, Wei YM. Construction and analysis of correlation networks based on gas chromatography-mass spectrometry metabonomics data for lipopolysaccharide-induced inflammation and intervention with volatile oil from Angelica sinensis in rats. Mol Biosyst 2015;11(11):3174-87.
12. Li J, Hua Y, Ji P, Yao W, Zhao H, Zhong L, et al. Effects of volatile oils of Angelica sinensis on an acute inflammation rat model. Pharm Biol 2016;54(9):1881-90.
13. Zhang WQ, Hua YL, Zhang M, Ji P, Li JX, Zhang L, et al. Metabonomic analysis of the anti-inflammatory effects of volatile oils of Angelica sinensis on rat model of acute inflammation. Biomed Chromatogr 2015;29(6):902-10.
14. Wang Q, Huang Y, Qin C, Liang M, Mao X, Li S, et al. Bioactive peptides from Angelica sinensis protein hydrolyzate delay senescence in Caenorhabditis elegans through antioxidant activities. Oxid Med Cell Longev 2016;8956981.
15. Zhuang C, Xu NW, Gao GM, Ni S, Miao KS, Li CK, et al. Polysaccharide from Angelica sinensis protects chondrocytes from H2O2-induced apoptosis through its antioxidant effects in vitro. Int J Biol Macromol 2016;87:322-8.
16. Yu F, Li H, Meng Y, Yang D. Extraction optimization of Angelica sinensis polysaccharides and its antioxidant activity in vivo. Carbohydr Polym 2013;94(1):114-9.
17. Zhang S, He B, Ge J, Li H, Luo X, Zhang H, et al. Extraction, chemical analysis of Angelica sinensis polysaccharides and antioxidant activity of the polysaccharides in ischemia-reperfusion rats. Int J Biol Macromol 2010; 47(4):546-50.
18. Lee MY, Seo CS, Lee JA, Lee NH, Kim JH, Ha H, et al. Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1. Food Chem Toxicol 2011;49(4):829-37.
19. Xu SF, Ye YP, Li XY, Chen FY. Chemical composition and antioxidant activities of different polysaccharides from the roots of Angelica dahurica. Chem Biodivers 2011;8(6):1121-31.
20. Rani MP, Padmakumari KP, Sankarikutty B, Cherian OL, Nisha VM, Raghu KG. Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress. Int J Food Sci Nutr 2011;62(2):106-10.
21. Rahman S, Salehin F, Iqbal A. In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines. BMC Complement Altern Med 2011;11:76.
22. Ahui ML, Champy P, Ramadan A, Pham Van L, Araujo L, Brou Andre K, et al. Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation. Int Immunopharmacol 2008;8(12):1626-32.
23. Shanmugam KR, Mallikarjuna K, Kesireddy N, Sathyavelu Reddy K. Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats. Food Chem Toxicol 2011;49(4):893-7.
24. Oboh G, Ademiluyi AO, Akinyemi AJ. Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale). Exp Toxicol Pathol 2012;64(4):315-9.
25. Cheng HL, Zhang LJ, Liang YH, Hsu YW, Lee IJ, Liaw CC, et al. Anti-inflammatory and antioxidant flavonoids and phenols from Cardiospermum halicacabum (Dao Di Ling). J Tradit Complement Med 2013;3(1):33-40.
26. Asha VV, Pushpangadan P. Antipyretic activity of Cardiospermum halicacabum. Indian J Exp Biol 1999;37(4):411-4.
27. Huang MH, Huang SS, Wang BS, Wu CH, Sheu MJ, Hou WC, et al. Antioxidant and anti-inflammatory properties of Cardiospermum halicacabum and its reference compounds ex vivo and in vivo. J Ethnopharmacol 2011;133(2):743-50.
28. Veeramani C, Pushpavalli G, Pugalendi KV. In vivo antioxidant and hypolipidemic effect of Cardiospermum halicacabum leaf extract in streptozotocin-induced diabetic rats. J Basic Clin Physiol Pharmacol 2010;21(2):107-25.
29. Juszczak L, Galkowska D, Ostrowska M, Socha R. Antioxidant activity of honey supplemented with bee products. Nat Prod Res 2016;30(12):1436-9.
30. Alzahrani HA, Boukraa L, Bellik Y, Abdellah F, Bakhotmah BA, Kolayli S, et al. Evaluation of the antioxidant activity of three varieties of honey from different botanical and geographical origins. Glob J Health Sci 2012;4(6):191-6.
31. Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U. Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Dig Surg 2002;19(4):306--311; discussion 11-2.
32. Nooh HZ, Nour-Eldien NM. The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis. Acta Histochem 2016;118(6):588-95.
33. El-Aidy WK, Ebeid AA, Sallam Ael R, Muhammad IE, Abbas AT, Kamal MA, et al. Evaluation of propolis, honey, and royal jelly in amelioration of peripheral blood leukocytes and lung inflammation in mouse conalbumin-induced asthma model. Saudi J Biol Sci 2015;22(6):780-8.
34. Hussein SZ, Mohd Yusoff K, Makpol S, Mohd Yusof YA. Gelam honey attenuates carrageenan-induced rat paw inflammation via NF-kappaB pathway. PLoS One 2013;8(8):e72365.
35. Owoyele BV, Adenekan OT, Soladoye AO. Effects of honey on inflammation and nitric oxide production in Wistar rats. Zhong Xi Yi Jie He Xue Bao 2011;9(4):447-52.
36. Bashkaran K, Zunaina E, Bakiah S, Sulaiman SA, Sirajudeen K, Naik V. Anti-inflammatory and antioxidant effects of Tualang honey in alkali injury on the eyes of rabbits: experimental animal study. BMC Complement Altern Med 2011;11:90.
37. Zoheir KM, Harisa GI, Abo-Salem OM, Ahmad SF. Honey bee is a potential antioxidant against cyclophosphamide-induced genotoxicity in albino male mice. Pak J Pharm Sci 2015;28(3):973-81.
38. Wang Y, Li D, Cheng N, Gao H, Xue X, Cao W, et al. Antioxidant and hepatoprotective activity of vitex honey against paracetamol induced liver damage in mice. Food Funct 2015;6(7):2339-49.
39. Sripanidkulchai B, Junlatat J. Bioactivities of alcohol based extracts of Phyllanthus emblica branches: antioxidation, antimelanogenesis and anti-inflammation. J Nat Med 2014;68(3):615-22.
40. Pientaweeratch S, Panapisal V, Tansirikongkol A. Antioxidant, anti-collagenase and anti-elastase activities of Phyllanthus emblica, Manilkara zapota and silymarin: an in vitro comparative study for anti-aging applications. Pharm Biol 2016;54(9):1865-72.
41. Tsai CC, Chou CH, Liu YC, Hsieh CW. Ultrasound-assisted extraction of phenolic compounds from Phyllanthus emblica L. and evaluation of antioxidant activities. Int J Cosmet Sci 2014;36(5):471-6.
42. Iamsaard S, Arun S, Burawat J, Sukhorum W, Wattanathorn J, Nualkaew S, et al. Phenolic contents and antioxidant capacities of Thai- Makham Pom (Phyllanthus emblica L.) aqueous extracts. J Zhejiang Univ Sci B2014;15(4):405-8.
43. Chatterjee UR, Bandyopadhyay SS, Ghosh D, Ghosal PK, Ray B. In vitro anti-oxidant activity, fluorescence quenching study and structural features of carbohydrate polymers from Phyllanthus emblica. Int J Biol Macromol 2011;49(4):637-42.
44. Poltanov EA, Shikov AN, Dorman HJ, Pozharitskaya ON, Makarov VG, Tikhonov VP, et al. Chemical and antioxidant evaluation of Indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L.) supplements. Phytotherapy Res 2009;23(9):1309-15.
45. Tasanarong A, Kongkham S, Itharat A. Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury. BMC Complement Altern Med 2014;14:138.
46. Dang GK, Parekar RR, Kamat SK, Scindia AM, Rege NN. Antiinflammatory activity of Phyllanthus emblica, Plumbago zeylanica and Cyperus rotundus in acute models of inflammation. Phytotherapy Res 2011;25(6):904-8.
47. Padumadasa C, Dharmadana D, Abeysekera A, Thammitiyagodage M. In vitro antioxidant, anti-inflammatory and anticancer activities of ethyl acetate soluble proanthocyanidins of the inflorescence of Cocos nucifera L. BMC Complement Altern Med 2016;16:345.
48. Silva RR, Oliveira e Silva D, Fontes HR, Alviano CS, Fernandes PD, Alviano DS. Anti-inflammatory, antioxidant, and antimicrobial activities of Cocos nucifera var. typica. BMC Complement Altern Med 2013;13:107.
49. Naskar S, Mazumder UK, Pramanik G, Saha P, Haldar PK, Gupta M. Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L. Inflammopharmacology 2013;21(1):31-5.
50. Rinaldi S, Silva DO, Bello F, Alviano CS, Alviano DS, Matheus ME, et al. Characterization of the antinociceptive and anti-inflammatory activities from Cocos nucifera L. (Palmae). J Ethnopharmacol 2009;122(3):541-6.
51. Sengar N, Joshi A, Prasad SK, Hemalatha S. Anti-inflammatory, analgesic and anti-pyretic activities of standardized root extract of Jasminum sambac. J Ethnopharmacol 2015;160:140-8.
52. Tanaka M, Kishimoto Y, Saita E, Suzuki-Sugihara N, Kamiya T, Taguchi C, et al. Terminalia bellirica extract inhibits low-density lipoprotein oxidation and macrophage inflammatory response in vitro. Antioxidants (Basel) 2016;5(2).
53. Sireeratawong S, Itharat A, Lerdvuthisopon N, Piyabhan P, Khonsung P, Boonraeng S, et al. Anti-inflammatory, analgesic, and antipyretic activities of the ethanol extract of Piper interruptum Opiz. and Piper chaba Linn. ISRN Pharmacol;2012:480265.
54. Okpanyi SN, Ezeukwu GC. Anti-inflammatory and antipyretic activities of Azadirachta indica. Planta Med 1981;41(1):34-9.
55. Koul A, Bharrhan S, Singh B, Rishi P. Potential of Azadirachta indica against Salmonella typhimurium-induced inflammation in BALB/c mice. Inflammopharmacology 2009;17(1):29-36.
56. Chakraborty A, Brantner AH. Study of alkaloids from Adhatoda vasica Nees on their anti-inflammatory activity. Phytotherapy Res 2001;15(6):532-4.
57. Singh B, Sharma RA. Anti-inflammatory and antimicrobial properties of pyrroloquinazoline alkaloids from Adhatoda vasica Nees. Phytomedicine 2013;20(5):441-5.
58. Singh RP, Padmavathi B, Rao AR. Modulatory influence of Adhatoda vesica (Justicia adhatoda) leaf extract on the enzymes of xenobiotic metabolism, antioxidant status and lipid peroxidation in mice. Mol Cell Biochem 2002;213(1-2):99-109.
59. Sagnia B, Fedeli D, Casetti R, Montesano C, Falcioni G, Colizzi V. Antioxidant and anti-inflammatory activities of extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva medicinal plants collected in Cameroon. PLoS One 2014;9(8):e103999.
60. Iqbal M, Gnanaraj C. Eleusine indica Linn possesses antioxidant activity and precludes carbon tetrachloride (CCl(4))-mediated oxidative hepatic damage in rats. Environ Health Prev Med 2012;17(4):307-15.
61. Durak A, Gawlik-Dziki U, Pecio L. Coffee with cinnamon - impact of phytochemicals interactions on antioxidant and anti-inflammatory in vitro activity. Food Chem 2014;162:81-8.
62. Sariozkan S, Turk G, Guvenc M, Yuce A, Ozdamar S, Canturk F, et al. Effects of Cinnamon (C. zeylanicum) bark oil against Taxanes-induced damages in sperm quality, testicular and epididymal oxidant antioxidant balance, testicular apoptosis, and sperm DNA integrity. Nutr Cancer 2016.;68(3):481-94.
63. Sahib AS. Anti-diabetic and antioxidant effect of cinnamon in poorly controlled type-2 diabetic Iraqi patients: A randomized, placebo-controlled clinical trial. J Intercult Ethnopharmacol 2016;5(2):108-13.
64. Lumlerdkij N, Poonpaiboonrote N, Akarasereenont P. Evidence-based medicine and Thai Traditional Medicine. J Thai Trad Altern Med. 2011;9(2):94-9.