Misdiagnosis of Anaphylaxis in Children in Buriram Hospital

Main Article Content

Lalita Tearprasert

Abstract

Background : Incidence of anaphylaxis in children varies associated with differences in population, places of occurrence, and geographic areas. Misdiagnosis and improper treatment were found.


Objective : To investigate the incidence, characteristic, and factors influencing the diagnosis of anaphylaxis children in Buriram Hospital, Thailand


Methods : A retrospective review, based on ICD-10 electronic medical records of anaphylactic children in Buriram Hospital from January 2017 to December 2019.    


Results : A total of 131 episodes of anaphylaxis in 113 children were analyzed. Misdiagnosis 46 episodes (35.1%), all were overdiagnosis. The incidence rate was 110 episodes per 100,000 patient. Most were male. Median age range 10 to 14 years. Skin were the most common presentation (99.2%). Foods were the most common culprit (35.1%). Significant factors of correct diagnosis were presenting with respiratory system (p=0.002), cardiovascular (p=0.019), cause and route of allergen (p=0.000). Pediatricians were more over diagnosis than general doctors (p=0.021).


Conclusion : The incidence of anaphylaxis in Buriram hospital appears more often than other hospitals in Thailand. All of misdiagnosis were overdiagnosis. Significant factors were presenting symptoms, cause and route of allergen, diagnosed person and place of diagnosis. Improper treatment and follow-up were found. Anaphylactic guideline might contribute to a better diagnosis and management.

Article Details

How to Cite
1.
Tearprasert L. Misdiagnosis of Anaphylaxis in Children in Buriram Hospital. Siriraj Med Bull [Internet]. 2021 Jul. 1 [cited 2024 Dec. 22];14(3):24-32. Available from: https://he02.tci-thaijo.org/index.php/simedbull/article/view/249683
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Original Article

References

Simons FE, Ardusso LR, Bilò MB, El-Gamal YM, Ledford DK, Ring J, et al. World allergy organization guidelines for the assessment and management of anaphylaxis. World Allergy Organization Journal. 2011 Jan 1;4(2):13-37.3.

Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson Jr NF, Bock SA, Branum A, et al. Second symposium on

the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. Journal of Allergy and Clinical Immunology. 2006 Feb 1;117(2):391-7.3.

Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J, et al. Anaphylaxis—a practice

parameter update 2015. Annals of Allergy, Asthma & Immunology. 2015 Nov 1;115(5):341-84.

Tejedor-Alonso MA, Moro-Moro M, Múgica-García MV. Epidemiology of Anaphylaxis: Contributions From the Last 10 Years. Journal of investigational allergology& clinical immunology. 2015 Jan 1;25(3):163-75.

Jirapongsananuruk O, Bunsawansong W, Piyaphanee N, Visitsunthorn N, Thongngarm T, Vichyanond P. Features of patients with anaphylaxis admitted to a university hospital. Annals of Allergy, Asthma & Immunology. 2007 Feb 1;98(2):157-62.

Techapornroong M, Akrawinthawong K, Cheungpasitporn W, Ruxrungtham K. Anaphylaxis: a ten years inpatient retrospective study. Asian Pac J Allergy Immunol. 2010 Dec 1;28(4):262-9.

Manuyakorn W, Benjaponpitak S, Kamchaisatian W, Vilaiyuk S, Sasisakulporn C, Jotikasthira W. Pediatric

anaphylaxis: triggers, clinical features, and treatment in a tertiary-care hospital. Asian Pac J Allergy Immunol.

Dec 1;33(4):281-8.

Jungkraisri, S. Anaphylaxis in pediatric inpatient of BhumibolAdulyadej Hospital. Royal Thai Air Force Medicine

Gazette. 2010, 56(1), 47.

Lertnawapan R. Anaphylaxis and biphasic phase in Thailand: 4-year observation. Allergology International.

Jan 1;60(3):283-9.

Rangkakulnuwat P, Sutham K, Lao-Araya M. Anaphylaxis: Ten-year retrospective study from a tertiary-care

hospital in Asia. Asian Pac J Allergy Immunol. 2020 Mar 1;38:31-9.

คณะทำงานเพื่อการรักษาและป้องกันการแพ้ชนิดรุนแรงแห่งประเทศไทย. แนวทางเวชปฏิบัติสำหรับการดูแลผู้ป่วยที่มีการแพ้ชนิดรุนแรง พ.ศ.2560:1-34.

Turner PJ, Campbell DE, Motosue MS, Campbell RL. Global trends in anaphylaxis epidemiology and clinical

implications. The Journal of Allergy and Clinical Immunology: In Practice. 2020 Apr 1;8(4):1169-76.

Simons FE. Anaphylaxis. J Allergy Clin Immunol. 2010;125:S161-81.

Jirapongsananuruk O, Bunsawansong W, Piyaphanee N, Visitsunthorn N, Thongngarm T, Vichyanond P. Features of patients with anaphylaxis admitted to a university hospital. Annals of Allergy, Asthma & Immunology. 2007 Feb 1;98(2):157-62.

Techapornroong M, Akrawinthawong K, Cheungpasitporn W, Ruxrungtham K. Anaphylaxis: a ten years inpatient retrospective study. Asian Pac J Allergy Immunol. 2010 Dec 1;28(4):262-9.

Thatphet P, Ienghong K, Gaysonsiri D, Apiratwarakul K, Ruttanaseeha W. Anaphylaxis in Emergency room

Srinagarind Hospital: A 5-Years Retrospective Study. Srinagarind Medical Journal. 2017 Dec 20;32(6):534-41.

KowjiriyapanY. Clinical Features of Anaphylaxis in the Emergency Medicine Department of Chiangrai

Prachanukroh Hospital. Chiangrai Medical Journal.2017; 9(2) : 30-39.

Panesar SS, Javad S, De Silva D, Nwaru BI, Hickstein L, Muraro A, et al. The epidemiology of anaphylaxis in

Europe: a systematic review. Allergy. 2013 Nov;68(11):1353-61.

Sclar DA, Lieberman PL. Anaphylaxis: underdiagnosed, underreported, and undertreated. The American journal of medicine. 2014 Jan 1;127(1):S1-5.

Klein JS, Yocum MW. Underreporting of anaphylaxis in a community emergency room. Journal of allergy and

clinical immunology. 1995 Feb 1;95(2):637-8.

Brown S, Kemp S, Lieberman P. Anaphylaxis. In: Adkinson Jr NF, Bochner BS, Burks AW, Busse WW, Holgate ST, Lemanske RF, et al. Middleton's allergy E-Book: Principles and practice. Elsevier Health Sciences; 2013 Sep 18.p.1237-59.

Kemp SF, Lockey RF, Simons FE. Epinephrine: the drug of choice for anaphylaxis--a statement of the World

Allergy Organization. World Allergy Organization Journal. 2008 Dec;1(2):1-9.

Simons KJ, Simons FE. Epinephrine and its use in anaphylaxis: current issues. Current opinion in allergy and

clinical immunology. 2010 Aug 1;10(4):354-61.

Pluemchitmongkhon P. Clinical manifestations of Anaphylaxis at the Emergency Department. Khon Kaen Med J. 2011;35:36-43.

Sicherer SH, Simons FE. Epinephrine for first-aid management of anaphylaxis. Pediatrics. 2017 Mar 1;139(3).

Simons FER, Gu X, Silver NA, Simons KJ. EpiPen Jr versus EpiPen in young children weighing 15-30 kg at risk for anaphylaxis. J Allergy ClinImmunol 2002;109:171-5.

Motosue M, Bellolio MF, Van Houten HK, Shah ND, Campbell RL. Predictors of epinephrine dispensing and

allergy follow-up after emergency department visit for anaphylaxis. Annals of Allergy, Asthma & Immunology.

Nov 1;119(5):452-8.

Ratanaprug C, Srisuwatchari W, Jirapongsananuruk O, Visitsunthorn N, Pacharn P. Carrying rates of epinephrine

devices in children with food-induced anaphylaxis. Asia Pacific Allergy. 2019 Apr;9(2).