Siriraj Clinical Pathway for Pregnant Women with Chronic Hepatitis B

Article Sidebar

PDF
Published: Jan 1, 2023
DOI: https://doi.org/10.33192/smb.v15i4.257660
Keywords:
pregnant women hepatitis B virus Siriraj hospital management

Main Article Content

Chenchit Chayachinda
Unit of Gynaecologic Infectious Diseases and Female STDs, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Supattra Rungmaitree
Unit of Paediatric infectious Diseases, Department of Paediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Supot Nimanong
Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Jitlada Iamharit
Internal Medicine Gastroenterology Samitivej Chonburi Hospital, Chonburi
Piyorot Preecha
Department of Nursing, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Malinee Tang-on
Department of Nursing, Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok

Abstract

Hepatitis B virus (HBV) infection is a major problem in pregnant women as it can be transmitted to intrauterine fetus and newborn (mother-to-child transmission: MTCT). As the risk of developing a chronic HBV infection is directly related to the age at which a person is first exposed to the HBV, the prevention of MTCT has been seriously taken into consideration. The younger persons are first infected, the greater the risk of developing a chronic HBV infection. Therefore, prevention of MTCT is an important approach to reducing the incidence of chronic patients. The keys to success includes blood testing for HBV viral load or hepatitis e antigen (HBeAg); commencement of antiviral drug if indicated; monitoring of compliance and side effects until 3 months post-partum; immediate initiation of passive and active immunity for newborns; and evaluation for HBV infection among infants at the age of 9-12 months. This article demonstrates the clinical pathway for pregnant women with chronic HBV infection at Siriraj Hospital.

Article Details

How to Cite
1.
Chayachinda C, Rungmaitree S, Nimanong S, Iamharit J, Preecha P, Tang-on M. Siriraj Clinical Pathway for Pregnant Women with Chronic Hepatitis B. Siriraj Med Bull [Internet]. 2023 Jan. 1 [cited 2024 Nov. 21];16(1):47-53. Available from: https://he02.tci-thaijo.org/index.php/simedbull/article/view/257660
Issue
Vol. 16 No. 1 (2023): January-March
Section
Review Article
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Crossref
Scopus
Google Scholar
Europe PMC

References

American Academy of Pediatrics. Hepatitis B. In: Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH, eds. Redbook 2021: Report of the Committee on Infectious Diseases. 32nd eds. Itasca, IL: American Academy of Pediatrics: 2021. pp.381-399.

Posuwan N, Wanlapakorn N, Sa-Nguanmoo P, Wasitthankasem R, Vichaiwattana P, Klinfueng S, et al. The Success of a Universal Hepatitis B Immunization Program as Part of Thailand's EPI after 22 Years' Implementation. PLoS One. 2016;11(3):e0150499.

Mavilia MG, Wu GY. Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis. J Clin Transl Hepatol. 2017;5(2):119-29.

Chamroonkul N, Piratvisuth T. Hepatitis B During Pregnancy in Endemic Areas: Screening, Treatment, and Prevention of Mother-to-Child Transmission. Paediatr Drugs. 2017;19(3):173-81.

Thamkhantho M, Chayachinda C. Characteristics, Prevalence, and HBeAg Correlation of Hepatitis B in Pregnancy: A Siriraj Hospital Experience. J Med Assoc Thai. 2020;103:276-80.

Dunkelberg JC, Berkley EM, Thiel KW, Leslie KK. Hepatitis B and C in pregnancy: a review and recommendations for care. J Perinatol. 2014;34:882-91.

World Health Organization. Medical eligibility criteria for contraceptive use. Geneva2015.

Connolly T, Zuckerman A. Contraception in the patient with liver disease. Semin Perinatol. 1998;22;178-82