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Hepatitis B virus (HBV) infection is a major problem in pregnant women as it can be transmitted to intrauterine fetus and newborn (mother-to-child transmission: MTCT). As the risk of developing a chronic HBV infection is directly related to the age at which a person is first exposed to the HBV, the prevention of MTCT has been seriously taken into consideration. The younger persons are first infected, the greater the risk of developing a chronic HBV infection. Therefore, prevention of MTCT is an important approach to reducing the incidence of chronic patients. The keys to success includes blood testing for HBV viral load or hepatitis e antigen (HBeAg); commencement of antiviral drug if indicated; monitoring of compliance and side effects until 3 months post-partum; immediate initiation of passive and active immunity for newborns; and evaluation for HBV infection among infants at the age of 9-12 months. This article demonstrates the clinical pathway for pregnant women with chronic HBV infection at Siriraj Hospital.
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