A Retrospective Study of Suk Sai Yad Recipe Uses in Patients with Insomnia

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Kulphassorn Jamparngernthaweesri
Natchagorn Lumlerdkij
Suksalin Booranasubkajorn
Pravit Akarasereenont


Objective: The primary objective of this study was to evaluate the effect on quality of life and sleep quality and safety of Suk sai yad recipe in patients with insomnia. The secondary objective was to investigate the relationship between various factors and effect of Suk sai yad recipe.

Materials and Methods: This study was a retrospective study conducted between August 2019 and June 2021 in 110 patients with insomnia, who were prescribed Suk sai yad recipe from 8 hospitals, by purposive sampling technique. The main outcomes were EQ-5D-5L quality of life score and perceived sleep quality collected at 1, 2, 3, 4, 8, 12 or 20 weeks after the treatment at least 1 time. Adverse effects and innate body elements were also recorded.

Results: The results showed that 59.1% of patients reported a better quality of life after the medication. The average EQ-5D-5L score after the medication (0.940 ± 0.128) was significantly increased from that of before (0.842 ± 0.183) (p < 0.001). For overall perceived sleep quality, 80% of patients reported an improved condition. Among these, there were 44.5% with better sleep quality and 27.3% with less waking up at night. There were 34.5% of patients who reported some adverse effects. The non-serious adverse effects were dried mouth and throat, dizziness, and heartburn. In addition, our analysis showed that the history of drug/herb allergy was associated with the incident of adverse effects (p < 0.001). Patients whose innate body elements were Fire had more opportunities of adverse effects than others.

Conclusion: This study shows that Suk sai yad recipe was effective and safe in relieving insomnia and improving the quality of life. However, uses of Suk sai yad recipe in some patients, such as those whose innate body element was Fire, should be careful due to the increased risk of adverse effects.

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Jamparngernthaweesri K, Lumlerdkij N, Booranasubkajorn S, Akarasereenont P. A Retrospective Study of Suk Sai Yad Recipe Uses in Patients with Insomnia. Siriraj Med Bull [Internet]. 2023 Apr. 1 [cited 2024 Jun. 17];16(2):119-30. Available from: https://he02.tci-thaijo.org/index.php/simedbull/article/view/260891
Original Article


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