ผลของสารสกัดคอลลาเจนต่อความชราทางผิวหนัง: การทบทวนวรรณกรรม

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ทรรศิน พงศ์ศิริสาทร
กฤดิภพ เจริญชัยปิยกุล
ประวิตร อัศวานนท์

บทคัดย่อ

ความชราทางผิวหนังเกิดจากปัจจัยภายในและปัจจัยภายนอก แสดงออกในลักษณะริ้วรอย ความชุ่มชื้น และความยืดหยุ่นที่ลดลง รวมไปถึงการสูญเสียการทำหน้าที่ของผิวหนัง กลไกสำคัญ คือ การลดลงของสารเร่งการเจริญเติบโตกลุ่มไฟโบรบลาสต์ ที่มีหน้าที่สำคัญในการสร้างสารเคลือบเซลล์ เช่น คอลลาเจน อีลาสติน ไฮยาลูรอน และคอนดรอยติน ซึ่งช่วยรักษาความชุ่มชื้น ความยืดหยุ่น และการคงรูปร่างผิวหนัง โดยเฉพาะคอลลาเจนซึ่งเป็นส่วนประกอบหลักที่สำคัญ ปัจจุบันพบว่ามีการสังเคราะห์สารสกัดคอลลาเจนจากแหล่งต่าง ๆ มากขึ้นและมีการศึกษาที่กล่าวถึงผลลัพธ์จากการรับประทานสารสกัดคอลลาเจนในการเพิ่มคุณภาพผิวหนังผ่านหลายกลไก เช่น การกระตุ้นเซลล์ไฟโบรบลาสต์ การปรับเปลี่ยนสภาพเซลล์ การลดการอักเสบ ดังนั้น การทบทวนความรู้เรื่องการรับประทานสารสกัดคอลลาเจนอย่างเหมาะสมจึงมีประโยชน์ในการลดภาวะความชราทางผิวหนัง

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