Factors Associated with Adherence to Medication in Major Depressive Disorder Patients
Keywords:
major depressive disorder, beliefs about depression, beliefs about medicines, patient- healthcare provider relationships, medication adherenceAbstract
Medication adherence is important for treatment of major depressive disorder (MDD). However, the rate of medication adherence is rather low. This descriptive correlational study aimed to investigate the association between gender, age, beliefs about depression, beliefs about medicine and patients, and the healthcare provider relationship with medication adherence in MDD patients. Eighty four MDD patients, both male and female, who received treatment at a psychiatric department of a community hospital were included in this study. The research instruments included a depression inventory, a personal data questionnaire, depression beliefs inventory, beliefs about medicines questionnaire, the California Pharmacotherapy Alliance scale (patient version), and a medication adherence report scale. Descriptive statistics, point biserial correlation, and Spearman’s rank correlation were used for data analysis.
Results showed that factors positively correlated with medication adherence in MDD patients were age (rs = .24, p < .05), beliefs about depression (rs = .45, p < .01), specific-necessity dimension of beliefs about medicines (rs = .32, p < .01), and patient-healthcare provider relationships (rs = .47, p < .01). Factors negatively correlated with medication adherence in MDD patients were beliefs about medicines-specific-concern dimension
(rs = -.27, p < .05), general - overuse dimension (rs = -.39, p < .01), and general-harm dimension
(rs = -.36, p < .01). However, gender had no relation with medication adherence (rs = .04, p > .05). The results from this study provide significant information to plan for promoting medication adherence in MDD patients.
References
1. World Health Organization. Depression [Internet]. 2017 [cited 2017 Mar 8]. Available from: http://www.who.int/mediacentre/factsheets/fs369/en/
2. Department of Mental Health. Ministry of public health. Annual report 2016 [Internet]. 2016 [cited 2018 Mar 8]. Available from: http://www.dmh.go.th/report/datacenter/map/reds.asp
3. Dunlop BW, Nemeroff CB. The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry 2007;64(3):327-37.
4. Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients 2016;8(1). pii: E56. doi: 10.3390/nu8010056.
5. Moret C, Briley M. The importance of norepinephrine in depression. Neuropsychiatr Dis Treat 2011;7(Suppl 1):9-13.
6. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.
7. Broder MS, Greene M, Yan T, Chang E, Hartry A, Yermilov I. Medication adherence, health care utilization, and costs in patients with major depressive disorder initiating adjunctive
atypical antipsychotic treatment. Clin Ther 2019;41(2):221-32.
8. Al Jumah K, Hassali MA., Al Qhatani D, El Tahir K. Factors associated with adherence to medication among depressed patients from Saudi Arabia: a cross-sectional study. Neuropsychiatr Dis Treat 2014;10:2031–7.
9. Alekhya P, Sriharsha M, Priya Darsini T, Reddy SK, Venkata Ramudu R. Treatment and disease related factors affecting nonadherence among patients on long term therapy of antidepressants. J Depress Anxiety 2015;4(2):175.
10. Sawada N, Uchida H, Suzuki T, Watanabe K, Kikuchi T, Handa T, et al. Persistence and compliance to antidepressant treatment in patients with depression: a chart review. BMC Psychiatry 2009;9:38.
11. Yau WY, Chan MC, Wing YK, Lam HB, Lin W, Lam SP, et al. Noncontinuous use of antidepressant in adults with major depressive disorders - a retrospective cohort study. Brain Behav 2014;4(3):390-7.
12. Prukkanone B, Vos T, Burgess P, Chaiyakunapruk N, Bertram M. Adherence to antidepressant therapy for major depressive patients in a psychiatric hospital in Thailand. BMC Psychiatry 2010:10;64.
13. Berwian IM, Walter H, Seifritz E, Huys QJM. Predicting relapse after antidepressant withdrawal-A systematic review. Psychol Med 2017;47(3):426-37.
14. Ho SC, Chong HY, Chaiyakunapruk N, Tangiisuran B, Jacob SA. Clinical and economic impact of non-adherence to antidepressants in major depressive disorder: a systematic review. J Affect Disord 2016;193:1-10.
15.Stein-Shvachman I, Karpas DS, Werner P. Depression treatment non-adherence and its psychosocial predictors: Differences between young and older adults?. Aging Dis 2013;4(6):329-36.
16. Dulchuprapha W, Werawattanachai C, Boonlue T. Impact of depression on work loss and disabilities in Thai patients with major depressive disorder. Thai Bull Pharm Sci 2016;11(2):1- 2. (in Thai)
17. Tang HY, Sayers SL, Weissinger G, Riegel B. The role of depression in medication adherence among heart failure patients. Clin Nurs Res 2014;23(3):231-44.
18. Greenberg PE, Fournier AA, Sisitsky T, Pike CT, Kessler RC. The economic burden of adults with major depressive disorder in the United States (2005 and 2010). J Clin Psychiatry 2015;76(2):155-62.
19. Roca M, Armengol S, Salvador-Carulla L, Monzon S, Salva J, Gili, M. Adherence to medication in depressive patients. J Clin Psychopharmacol 2011;31:541-3.
20. Lee MS, Lee HY, Kang SG, Yang J, Ahn H, Rhee M, et al. Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders. J Affect Disord 2010;123(1-3):216-21.
21. Yeh MY, Sung SC, Yorker BC, Sun CC, Kuo YL. Predictors of adherence to an antidepressant medication regimen among patients diagnosed with depression in Taiwan. Issues Ment Health Nurs 2008;29(7):701-17.20.
22. Banerjee S, Varma RP. Factors affecting non-adherence among patients diagnosed with unipolar depression in a psychiatric department of a tertiary hospital in Kolkata, India. Depress Res Treat 2013;2013:809542. doi: 10.1155/2013/809542.
23. Burra TA, Chen E, McIntyre RS, Grace SL, Blackmore ER, Stewart DE. (2007). Predictors of self-reported antidepressant adherence. Behav Med 2007;32(4):127-34.
24. Tamburrino MB, Nagel RW, Chahal MK, Lynch DJ. Antidepressant medication adherence:a study of primary care patients. Prim Care Companion J Clin Psychiatry 2009;11(5):205-11.
25. Shigemura J, Ogawa T, Yoshino A, Sato Y, Nomura S. Predictors of antidepressant adherence: results of a Japanese internet-based survey. Psychiatry Clin Neurosci 2010;64(2):179-86.
26. Suemram P, Wattanapailin A, Yuttatri P, Vongsirimas N. Correlation between beliefs about depression, social support, medical co-morbidity and drug adherence behavior in dlderly with major depressive disorder. The Journal of Baromarajonani College of Nursing, Nakhonratchasima 2016; 22(1):108-20. (in Thai)
27. Brown C, Battista DR, Bruehlman R, Sereika SS, Thase ME, Dunbar-Jacob J. Beliefs about antidepressant medications in primary care patients: relationship to self-reported adherence. Med Care 2005;43(12):1203-7.
28. De Las Cuevas C, Peñate W, Sanz EJ. Risk factors for non-adherence to antidepressant Treatment in patients with mood disorders. Eur J Clin Pharmacol 2014;70(1):89-98.
29. Department of Mental Health. Ministry of public health. Annual report 2015 [Internet]. 2015 [cited 2018 Mar 8]. Available from: http://www.dmh.go.th/report/datacenter/map/reds.asp
30. Horne R. The medication adheremce report scale (MARS). Hastings, UK: University of Brighton; 1996.
31. World Health Organization. Defining adherence [Internet]. 2013 [cited 2017 Mar 8]. Available from: http://apps.who.int/medicinedocs/en/d/Js4883e/8.9.1.html#Js4883e.8.9.1
32. Zhou Q, Wu ZG, Wang Y, Liu XH, Chen J, Wang Y, et al. Clinical characteristics associated with therapeutic nonadherence of the patients with major depressive disorder: a report on the national survey on symptomatology of depression in China. CNS Neurosci Ther 2019;25(2):215-22.
33. Krueger K, Botermann L, Schorr SG, Griese-Mammen N, Laufs U, Schulz M. Age-related medication adherence in patients with chronic heart failure: a systematic literature review. Int J Cardiol 2015;184:728-35.
34. Edlund MJ, Fortney JC, Reaves CM, Pyne JM, Mittal D. Beliefs about depression and depression treatment among depressed veterans. Med Care 2008;46(6):581-9.
35. Rungruangsiripan M, Sittimongkol Y, Maneesriwongul W, Talley S, Vorapongsathorn T. Mediating role of illness representation among social support, therapeutic alliance, experience of medication side effects, and medication adherence in persons with schizophrenia. Arch Psychiatr Nurs 2011;25(4):269-83.
36. Cheung K, Hicks J, McEwen B, Cianfarani G. Strong healthcare provider-patient relationship improves patient adherence and lowers healthcare costs: a meta-analysis [Internet]. 2012 [cited 2019 Mar 8]. Available from: https://mycred.com/libs/pdf/healthcare_ portfolios_patient_adherence.
37. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. United States of America: Lawrence Erlabum Associates; 1988.
38. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009;41(4):1149-60.
39. Lotrakul M, Sukanich P. Development of the Thai Depression Inventory. J Med Assoc Thai.1999;82(12):1200-7. (in Thai)
40. Horne R, Weinman J, Hankins M. The beliefs about medicines questionnaire: The developments and evaluation of a new method for assessing the cognitive representation of medication. sychol Health 1999;14:1-24.
41. Leaungsomnapa Y, Leaungsomanpa S, Promproh S, Thasirasawad P, Keawchaum R, Suworawatanakul W. Confirmatory factor analysis of beliefs about medicine questionnaire in Thai version. J Prapokklao Hosp Clin Med Educat Center 2014;31(4):297-310. (in Thai)
42. Gaston L, Marmar CR. Manual of California psychotherapy alliance scales (CALPAS) [unpublished manuscript]. Montreal, Quebec: McGill University; 1991.
43. Bull SA, Hu XH, Hunkeler EM, Lee JY, Ming EE, Markson LE, et al. (2002). Discontinuation of use and switching of antidepressants: Influence of patient-physician communication. JAMA 002;288(11):1403-9.
44. D'Zurilla TJ, Maydeu-Olivares A, Kant GL. Age and gender differences in social problem-solving ability. Pers Indiv Differ 1998;25(2):241–52.
45. Kim-Romo DN, Rascati KL, Richards KM, Ford KC, Wilson JP, Beretvas SN. Medication adherence and persistence in patients with severe major depressive disorder with psychotic features: ntidepressant and second-generation antipsychotic therapy versus antidepressant monotherapy. J Manag Care Spec Pharm 2016;22(5):588-96
46. Broadhead WE, Blazer DG, George LK, Tse CK. Depression, disability days, and days lost from work in a prospective epidemiologic survey. JAMA 1990;264(19):2524-8.
47. Fried EI, Nesse RM. The impact of individual depressive symptoms on impairment of Psychosocial functioning. PLoS One 2014;9(2):e90311. doi: 10.1371/journal.pone.0090311.
48. Aikens JE, Nease DE, Nau DP, Klinkman MS, Schwenk TL. Adherence to maintenance-phase antidepressant medication as a function of patient beliefs about medication. Ann Fam Med 2005;3(1):23-30.
49. Chakraborty K, Avasthi A, Kumar S, Grover S. Attitudes and beliefs of patients of first episode depression towards antidepressants and their adherence to treatment. Soc Psychiatry Psychiatr Epidemiol 2009;44(6):482-8.
50. Lynch J, Kendrick T, Moore M, Johnston O, Smith PWF. Patients’ beliefs about depression and how they relate to duration of antidepressant treatment. Use of a US measure in a UK primary care population. Prim Ment Health Care 2006;4:1-11.
51. Alatawi YM, Kavookjian J, Ekong G, Alrayees MM. The association between health beliefs and medication adherence among patients with type 2diabetes. Res Social Adm Pharm 2016;12(6):914-25.
52. Beck AT. American handbook of psychiatry: depressive neurosis [Internet]. 1974 [cited 2017 Mar 8]. Available from: http://www.freepsychotherapybook.org
53. Leventhal H, Brissette I, Leventhal EA. The common-sense model of self-regulation of health and illness. In: Cameron LD, Leventhal H, editors. The self-regulation of health and illness behavior. New York: Routledge; 2003. pp. 42-65.
54. Horne R. Representations of medication and treatment: advances in theory and measurement. In: Petrie KJ, Weinman JA, editors. Perceptions of health and illness: current research and applications. Amsterdam, Netherlands: Harwood; 1997. pp. 155-88
55. Kalogianni A. Factors affect in patient adherence to medication regimen. Health Sci J 2011;5(3):157-8
56. Grillo V, Tan D, Zhao X, Teoh C, Stankus A P. Patients’ attitudes to doctor, treatment satisfaction and adherence: a comparison of urban China and Japan. Value Health [Internet]. 2018 [cited 2019 Mar 8];21:S90. doi: https://doi.org/10.1016/j.jval.2018.07.675
57. Jamous RM, Sweileh WM, El-Deen Abu Taha AS, Zyoud SH. Beliefs about medicines and self-reported adherence among patients with chronic illness: a study in Palestine. J Family Med Prim Care 2014;3(3):224-9.
2. Department of Mental Health. Ministry of public health. Annual report 2016 [Internet]. 2016 [cited 2018 Mar 8]. Available from: http://www.dmh.go.th/report/datacenter/map/reds.asp
3. Dunlop BW, Nemeroff CB. The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry 2007;64(3):327-37.
4. Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients 2016;8(1). pii: E56. doi: 10.3390/nu8010056.
5. Moret C, Briley M. The importance of norepinephrine in depression. Neuropsychiatr Dis Treat 2011;7(Suppl 1):9-13.
6. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.
7. Broder MS, Greene M, Yan T, Chang E, Hartry A, Yermilov I. Medication adherence, health care utilization, and costs in patients with major depressive disorder initiating adjunctive
atypical antipsychotic treatment. Clin Ther 2019;41(2):221-32.
8. Al Jumah K, Hassali MA., Al Qhatani D, El Tahir K. Factors associated with adherence to medication among depressed patients from Saudi Arabia: a cross-sectional study. Neuropsychiatr Dis Treat 2014;10:2031–7.
9. Alekhya P, Sriharsha M, Priya Darsini T, Reddy SK, Venkata Ramudu R. Treatment and disease related factors affecting nonadherence among patients on long term therapy of antidepressants. J Depress Anxiety 2015;4(2):175.
10. Sawada N, Uchida H, Suzuki T, Watanabe K, Kikuchi T, Handa T, et al. Persistence and compliance to antidepressant treatment in patients with depression: a chart review. BMC Psychiatry 2009;9:38.
11. Yau WY, Chan MC, Wing YK, Lam HB, Lin W, Lam SP, et al. Noncontinuous use of antidepressant in adults with major depressive disorders - a retrospective cohort study. Brain Behav 2014;4(3):390-7.
12. Prukkanone B, Vos T, Burgess P, Chaiyakunapruk N, Bertram M. Adherence to antidepressant therapy for major depressive patients in a psychiatric hospital in Thailand. BMC Psychiatry 2010:10;64.
13. Berwian IM, Walter H, Seifritz E, Huys QJM. Predicting relapse after antidepressant withdrawal-A systematic review. Psychol Med 2017;47(3):426-37.
14. Ho SC, Chong HY, Chaiyakunapruk N, Tangiisuran B, Jacob SA. Clinical and economic impact of non-adherence to antidepressants in major depressive disorder: a systematic review. J Affect Disord 2016;193:1-10.
15.Stein-Shvachman I, Karpas DS, Werner P. Depression treatment non-adherence and its psychosocial predictors: Differences between young and older adults?. Aging Dis 2013;4(6):329-36.
16. Dulchuprapha W, Werawattanachai C, Boonlue T. Impact of depression on work loss and disabilities in Thai patients with major depressive disorder. Thai Bull Pharm Sci 2016;11(2):1- 2. (in Thai)
17. Tang HY, Sayers SL, Weissinger G, Riegel B. The role of depression in medication adherence among heart failure patients. Clin Nurs Res 2014;23(3):231-44.
18. Greenberg PE, Fournier AA, Sisitsky T, Pike CT, Kessler RC. The economic burden of adults with major depressive disorder in the United States (2005 and 2010). J Clin Psychiatry 2015;76(2):155-62.
19. Roca M, Armengol S, Salvador-Carulla L, Monzon S, Salva J, Gili, M. Adherence to medication in depressive patients. J Clin Psychopharmacol 2011;31:541-3.
20. Lee MS, Lee HY, Kang SG, Yang J, Ahn H, Rhee M, et al. Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders. J Affect Disord 2010;123(1-3):216-21.
21. Yeh MY, Sung SC, Yorker BC, Sun CC, Kuo YL. Predictors of adherence to an antidepressant medication regimen among patients diagnosed with depression in Taiwan. Issues Ment Health Nurs 2008;29(7):701-17.20.
22. Banerjee S, Varma RP. Factors affecting non-adherence among patients diagnosed with unipolar depression in a psychiatric department of a tertiary hospital in Kolkata, India. Depress Res Treat 2013;2013:809542. doi: 10.1155/2013/809542.
23. Burra TA, Chen E, McIntyre RS, Grace SL, Blackmore ER, Stewart DE. (2007). Predictors of self-reported antidepressant adherence. Behav Med 2007;32(4):127-34.
24. Tamburrino MB, Nagel RW, Chahal MK, Lynch DJ. Antidepressant medication adherence:a study of primary care patients. Prim Care Companion J Clin Psychiatry 2009;11(5):205-11.
25. Shigemura J, Ogawa T, Yoshino A, Sato Y, Nomura S. Predictors of antidepressant adherence: results of a Japanese internet-based survey. Psychiatry Clin Neurosci 2010;64(2):179-86.
26. Suemram P, Wattanapailin A, Yuttatri P, Vongsirimas N. Correlation between beliefs about depression, social support, medical co-morbidity and drug adherence behavior in dlderly with major depressive disorder. The Journal of Baromarajonani College of Nursing, Nakhonratchasima 2016; 22(1):108-20. (in Thai)
27. Brown C, Battista DR, Bruehlman R, Sereika SS, Thase ME, Dunbar-Jacob J. Beliefs about antidepressant medications in primary care patients: relationship to self-reported adherence. Med Care 2005;43(12):1203-7.
28. De Las Cuevas C, Peñate W, Sanz EJ. Risk factors for non-adherence to antidepressant Treatment in patients with mood disorders. Eur J Clin Pharmacol 2014;70(1):89-98.
29. Department of Mental Health. Ministry of public health. Annual report 2015 [Internet]. 2015 [cited 2018 Mar 8]. Available from: http://www.dmh.go.th/report/datacenter/map/reds.asp
30. Horne R. The medication adheremce report scale (MARS). Hastings, UK: University of Brighton; 1996.
31. World Health Organization. Defining adherence [Internet]. 2013 [cited 2017 Mar 8]. Available from: http://apps.who.int/medicinedocs/en/d/Js4883e/8.9.1.html#Js4883e.8.9.1
32. Zhou Q, Wu ZG, Wang Y, Liu XH, Chen J, Wang Y, et al. Clinical characteristics associated with therapeutic nonadherence of the patients with major depressive disorder: a report on the national survey on symptomatology of depression in China. CNS Neurosci Ther 2019;25(2):215-22.
33. Krueger K, Botermann L, Schorr SG, Griese-Mammen N, Laufs U, Schulz M. Age-related medication adherence in patients with chronic heart failure: a systematic literature review. Int J Cardiol 2015;184:728-35.
34. Edlund MJ, Fortney JC, Reaves CM, Pyne JM, Mittal D. Beliefs about depression and depression treatment among depressed veterans. Med Care 2008;46(6):581-9.
35. Rungruangsiripan M, Sittimongkol Y, Maneesriwongul W, Talley S, Vorapongsathorn T. Mediating role of illness representation among social support, therapeutic alliance, experience of medication side effects, and medication adherence in persons with schizophrenia. Arch Psychiatr Nurs 2011;25(4):269-83.
36. Cheung K, Hicks J, McEwen B, Cianfarani G. Strong healthcare provider-patient relationship improves patient adherence and lowers healthcare costs: a meta-analysis [Internet]. 2012 [cited 2019 Mar 8]. Available from: https://mycred.com/libs/pdf/healthcare_ portfolios_patient_adherence.
37. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. United States of America: Lawrence Erlabum Associates; 1988.
38. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009;41(4):1149-60.
39. Lotrakul M, Sukanich P. Development of the Thai Depression Inventory. J Med Assoc Thai.1999;82(12):1200-7. (in Thai)
40. Horne R, Weinman J, Hankins M. The beliefs about medicines questionnaire: The developments and evaluation of a new method for assessing the cognitive representation of medication. sychol Health 1999;14:1-24.
41. Leaungsomnapa Y, Leaungsomanpa S, Promproh S, Thasirasawad P, Keawchaum R, Suworawatanakul W. Confirmatory factor analysis of beliefs about medicine questionnaire in Thai version. J Prapokklao Hosp Clin Med Educat Center 2014;31(4):297-310. (in Thai)
42. Gaston L, Marmar CR. Manual of California psychotherapy alliance scales (CALPAS) [unpublished manuscript]. Montreal, Quebec: McGill University; 1991.
43. Bull SA, Hu XH, Hunkeler EM, Lee JY, Ming EE, Markson LE, et al. (2002). Discontinuation of use and switching of antidepressants: Influence of patient-physician communication. JAMA 002;288(11):1403-9.
44. D'Zurilla TJ, Maydeu-Olivares A, Kant GL. Age and gender differences in social problem-solving ability. Pers Indiv Differ 1998;25(2):241–52.
45. Kim-Romo DN, Rascati KL, Richards KM, Ford KC, Wilson JP, Beretvas SN. Medication adherence and persistence in patients with severe major depressive disorder with psychotic features: ntidepressant and second-generation antipsychotic therapy versus antidepressant monotherapy. J Manag Care Spec Pharm 2016;22(5):588-96
46. Broadhead WE, Blazer DG, George LK, Tse CK. Depression, disability days, and days lost from work in a prospective epidemiologic survey. JAMA 1990;264(19):2524-8.
47. Fried EI, Nesse RM. The impact of individual depressive symptoms on impairment of Psychosocial functioning. PLoS One 2014;9(2):e90311. doi: 10.1371/journal.pone.0090311.
48. Aikens JE, Nease DE, Nau DP, Klinkman MS, Schwenk TL. Adherence to maintenance-phase antidepressant medication as a function of patient beliefs about medication. Ann Fam Med 2005;3(1):23-30.
49. Chakraborty K, Avasthi A, Kumar S, Grover S. Attitudes and beliefs of patients of first episode depression towards antidepressants and their adherence to treatment. Soc Psychiatry Psychiatr Epidemiol 2009;44(6):482-8.
50. Lynch J, Kendrick T, Moore M, Johnston O, Smith PWF. Patients’ beliefs about depression and how they relate to duration of antidepressant treatment. Use of a US measure in a UK primary care population. Prim Ment Health Care 2006;4:1-11.
51. Alatawi YM, Kavookjian J, Ekong G, Alrayees MM. The association between health beliefs and medication adherence among patients with type 2diabetes. Res Social Adm Pharm 2016;12(6):914-25.
52. Beck AT. American handbook of psychiatry: depressive neurosis [Internet]. 1974 [cited 2017 Mar 8]. Available from: http://www.freepsychotherapybook.org
53. Leventhal H, Brissette I, Leventhal EA. The common-sense model of self-regulation of health and illness. In: Cameron LD, Leventhal H, editors. The self-regulation of health and illness behavior. New York: Routledge; 2003. pp. 42-65.
54. Horne R. Representations of medication and treatment: advances in theory and measurement. In: Petrie KJ, Weinman JA, editors. Perceptions of health and illness: current research and applications. Amsterdam, Netherlands: Harwood; 1997. pp. 155-88
55. Kalogianni A. Factors affect in patient adherence to medication regimen. Health Sci J 2011;5(3):157-8
56. Grillo V, Tan D, Zhao X, Teoh C, Stankus A P. Patients’ attitudes to doctor, treatment satisfaction and adherence: a comparison of urban China and Japan. Value Health [Internet]. 2018 [cited 2019 Mar 8];21:S90. doi: https://doi.org/10.1016/j.jval.2018.07.675
57. Jamous RM, Sweileh WM, El-Deen Abu Taha AS, Zyoud SH. Beliefs about medicines and self-reported adherence among patients with chronic illness: a study in Palestine. J Family Med Prim Care 2014;3(3):224-9.
Downloads
Published
2020-08-03
Issue
Section
บทความวิจัย (Research Report)
License
เนื้อหาบทความหรือข้อคิดเห็นต่างๆ ในวารสารพยาบาลสภากาชาดไทยนี้ เป็นความคิดเห็นของผู้เขียนบทความ ไม่ใช่ความเห็นของกองบรรณาธิการ หรือสถาบันการพยาบาลศรีสวรินทิรา สภากาชาดไทย
