Diagnostic Performance of Abnormal Conventional Cervical Pap smear result at Mahasarakham Hospital
Abstract
Cervical cancer is commonly found in Thai women and worldwide. Mahasarakham hospital has implemented the national cervical cancer screening policy (conventional cervical Pap smear) since 2005. However, there is no previous study to evaluate the diagnostic performance of the abnormal Pap smear result at Mahasarakham hospital. This study was a diagnostic test study objective to evaluate the diagnostic performance of abnormal Pap smear (precancerous lesions and cervical cancer) at Mahasarakham Hospital. The data was retrospectively collected from 2015 to 2019. The abnormal Pap smear results were compared with the histopathologic reports. Then, the diagnostic performances were analysed.
Results: There were 139,268 cases of conventional Pap smear with 530 cases of abnormal result (precancerous and cancer) within the study period. The sensitivity and specificity of low grade squamous intraepithelial lesion (LSIL) from Pap smear report were 70.00% and 64.57%, respectively. The sensitivity and specificity of high grade squamous intraepithelial lesion (HSIL) from Pap smear report were 73.25% and 87.23%, respectively. The sensitivity and specificity of cervical malignancy from Pap smear report were 54.17% and 99.21%, respectively.
Conclusion: This study shows moderate sensitivity and specificity diagnosis in LSIL and moderate sensitivity, but high specificity diagnosis in HSIL and cervical cancer. Improving sampling collection, specimen preparation, cytological interpretation of cytologist and expert consultation are essential to achieve concurrently high sensitivity and specificity.
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