Etiology of Acute Abdominal Pain in Children Hospitalized in The General Pediatric Ward

Authors

  • Wittayathorn Pornsiripratharn Department of Pediatrics, Udonthani hospital, Udonthani

Keywords:

pediatric patients, acute abdominal pain, acute appendicitis, acute gastroenteritis

Abstract

Acute abdominal pain is a common problem in children. The etiologies are varied and range from benign, self-limiting conditions to life-threatening surgical conditions such as acute appendicitis. Patients with more severe symptoms and uncertain diagnosis usually require hospitalization and clinical observation. The aim of this retrospective descriptive study was to evaluate the etiologies of children aged 2-15 years old with acute abdominal pain of less than 7 days’ duration who were hospitalized in the general pediatric ward in Udon Thani hospital between January 1st, 2016 and December 31st, 2022. All patients who met the inclusion criteria were enrolled and data were collected from medical records. Frequency, percentage, mean, S.D., median, and interquartile range were used for descriptive analysis.

          The 7 years data included 269 patients with mean age 8.0 years old, 51.3% male. The most common location of the pain was in the periumbilical region (37.2%). The most frequent etiology was acute gastroenteritis (53.2%), followed by constipation (17.1%), and abdominal pain with unknown etiology (13.0%). Acute appendicitis was found 8.9% of patients. Acute gastroenteritis was significantly more frequent in patients with abdominal pain of 1-2 days' duration than 3-6 days' duration (59.3% vs 38.8%, p=0.002), while constipation and abdominal pain with unknown etiology were significantly more frequent in those with 3-6 days' duration compared to 1-2 days' duration (27.5% vs 12.7%, p=0.003 and 20.0% vs 10.1%, p=0.027, respectively). Acute appendicitis was significantly more frequent in patients with right lower quadrant pain when compared to those with periumbilical pain (33.3% vs 13.0%, p=0.031).

          In conclusion, this study showed that acute gastroenteritis was the most frequent etiology (53.2%) of children who were hospitalized due to acute abdominal pain. Acute gastroenteritis, constipation, and abdominal pain with unknown etiology were associated with pain duration, while acute appendicitis was associated with right lower quadrant pain.

References

Loening-Baucke V, Swidsinski A. Constipation as cause of acute abdominal pain in children. J Pediatr 2007;151:666-9.

Erkan T, Cam H, Ozkan HC, Kiray E, Erginoz E, Kutlu T, et al. Clinical spectrum of acute abdominal pain in Turkish pediatric patients: a prospective study. Pediatric Int 2004;46:325-9.

Scholer SJ, Pituch K, Orr DP, Dittus RS. Clinical outcomes of children with acute abdominal pain. Pediatrics 1996;98:680-5.

Miranda A. Abdominal pain. In: Kliegman RM, Lye PS, Bordini BJ, Toth H, Basel D., editors. Nelson Pediatric Symptom-Based Diagnosis. Philadelphia: Elsevier; 2018: 161-81.

John J. Acute appendicitis. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, Behrman RE., editors. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: Elsevier; 2016: 1887-93.

Becker T, Kharbanda A, Bachur R. Atypical clinical features of pediatric appendicitis. Acad Emerg Med 2007;14:124-9.

St Peter SD, Wester T. Appendicitis. In: Holcomb GW, Murphy JP, St Peter SD., editors. Holcomb and Ashcraft’s Pediatric Surgery. 7th ed. Philadelphia: Elsevier; 2020: 664-74.

Ross A, LeLeiko NS. Acute abdominal pain. Pediatr Rev 2010;31:135-44.

Acheson J and Banerjee J. Management of suspected appendicitis in children. Arch Dis Child Educ Pract Ed 2010;95:9-13.

Kim JS. Acute abdominal pain in children. Pediatr Gastroenterol Hepatol Nutr 2013;16:219-24.

Bhutta ZA. Acute gastroenteritis in children. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, Behrman RE., editors. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: Elsevier; 2016: 1854-74.

Elliott EJ. Acute gastroenteritis in children. Br Med J 2007;334:35-40.

Liu QY, Mitsinikos FT, Michail S. Gastritis, gastropathy, and ulcer disease. In: Wyllie R, Hyams JS, Kay M., editors. Pediatric gastrointestinal and liver disease. 5th ed. Philadelphia: Elsevier; 2016: 294-308.

Arias C, Sala MR, Domínguez, Torner N, Ruíz L, Martínez A, et al. Epidemiological and clinical features of norovirus gastroenteritis in outbreaks: a population-based study. Clin Microbiol Infect 2010;16:39-44.

Subahir MN, Jeffree MS, Hassan MR, Razak MFA, Mohamad SNG, Fong SY, et al. Norovirus outbreak among students of a boarding school in Kluang, Johor, Malaysia. J Infect Dev Ctries 2019;13:274-277.

Carol M, Guadalupe-Fernández V, Rius C, Soldevila N, Razquin E, Guix S, et al. A waterborne gastroenteritis outbreak caused by a GII norovirus in a holiday camp in Catalonia (Spain), 2017. Viruses 2021;13:1792.

Shieh WJ. Human adenovirus infections in pediatric population–An update on clinico-pathologic correlation. Biomed J 2022;45:38-49.

Same RG and Tamma PD. Campylobacter infections in children. Pediatr Rev 2018;39:533-41.

Terzi MAP, Prod’hom G, Croxatto A, Andrey V, Crisinel PA. Acute abdominal emergency due to infectious enteritis: an observational study comparing Campylobacter spp. to other enteric pathogens in children. Swiss Med Wkly 2022;152:w30113.

Jang WT, Jo NH, Song MO, Eun BW, Ahn YM. Campylobacter enteritis: Clinical

features and laboratory findings in children treated at a single hospital. Pediatr Infect Vaccine 2019;26:22-31.

Cohen MB. Bacterial infections, food- and waterborne infections. In: Kleinman RE, Goulet OJ, Mieli-Vergani G, Sanderson IR, Sherman PM, Shneider BL, editors. Walker’s pediatric gastrointestinal disease. 6th ed. PMPH-USA; 2018: 631-60.

Shaw AN, Heresi GP, Murphy JR. Campylobacter. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, Behrman RE., editors. Nelson Textbook of Pediatricss. 20th ed. Philadelphia: Elsevier; 2016:1403-6.

Chanachai K, Pittayawonganon C, Areechokchai D, Suchatsoonthorn C, Pokawattana L, Jiraphongsa C. A food borne outbreak of gastroenteritis due to shigella and possibly salmonella in a school. Southeast Asian J Trop Med Public Health 2008;39(2):297-302.

Guarino A, Ashkenazi S, Gendrel D, Vecchio AL, Shamir R, Szajewska H. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: Update 2014. J Pediatr Gastroenterol Nutr 2014;59:132-52.

Chandola TR, Taneja S, Goyal N, Rathore SS, Appaiahgari MB, Mishra A, et al. Descriptive epidemiology of rotavirus infection in a community in North India. Epidemiol Infect 2013;141: 2094–100.

de Wit MA, Koopmans MP, Kortbeek LM, Wannet WJ, Vinje J, Van Leusden F, et al. Sensor, a population-based cohort study on gastroenteritis in the Netherlands: incidence and etiology. Am J Epidemiol 2001;154:666-74.

Heyworth JS, Glonek G, Maynard EJ, Baghurst PA, Finlay-Jones J Consumption of untreated

tank rainwater and gastroenteritis among young children in South Australia. Int J Epidemiol 2006; 35:1051-8.

Schlinkmann KM, Bakuli A, Karch A, Meyer F, Dreesman J, Monazahian M, et al. Transmission of respiratory and gastrointestinal infections in German households with children attending child care. Epidemiol Infect 2018;146:627-32.

Enserink R, Noel H, Friesema IH, De Jager CM, Kooistra-Smid AM, Kortbeek LM, et al. The KIzSS network, a sentinel surveillance system for infectious diseases in day care centers: study

protocol. BMC Infect Dis 2012;12:259.

Romero C, Tinoco YO, Loli S, Razuri H, Soto G, Silva M, et al. Incidence of norovirus-associated diarrhea and vomiting disease among children and adults in a community cohort in the Peruvian Amazon basin. Clin Infect Dis 2017;65:833-9.

Olson D, Lamb MM, Lopez MR, Paniagua-Avila MA, Zacarias A, Samayoa-Reyes G, et al. A rapid epidemiological tool to measure the burden of norovirus infection and disease in resource-limited settings. Open Forum Infect Dis 2017;4(2):ofx049.

Stanyevic B, Sepich M, Biondi S, Baroncelli GI, Peroni D, Cicco MD. The evolving epidemiology of acute gastroenteritis in hospitalized children in Italy. Eur J Pediatr 2022;181: 349-58.

Hikita T, Phan T, Okitsu S, Hayakawa S, Ushijima H. A comparative study of acute gastroenteritis symptoms in single- versus multiple-virus infections. Int J Mol Sci 2023;24:8364.

Vivar KL and Uyeki TM. Influenza virus infection mimicking an acute abdomen in a female adolescent. Influenza Other Respir Viruses 2013;8:140-1.

Chan MCW, Lee N, Chan PKS, Leung TF, Sung JJY. Fecal detection of influenza A virus in patients with concurrent respiratory and gastrointestinal symptoms. J Clin Virol 2009;45:208-11.

Kerr AA, McQuillin J, Downham MA, Gardner PS. Gastric ‘flu influenza B causing abdominal symptoms in children. Lancet 1975;1:291-5.

Li HJ, Du J, Yang YN, Cui Y, Xi L, Wang S, et al. Outbreak of human parainfluenza virus type 1 in a kindergarten from China, 2018. J Pediatr Infect Dis 2020;15:25-30.

Pierrès-Surer N, Beby-Defaux A, Bourgoin A, Venot C, Berthier M, Grollier G, et al. Rhinovirus infections in hospitalized children: a 3-year study. Arch Pediatr 1998;5:9-14.

Chen HL, Chiou SS, Hsiao HP, Ke GM, Lin YC, Lin KH, et al. Respiratory adenoviral infections in children: a study of hospitalized cases in southern Taiwan in 2001-2002. J Trop Pediatr 2004; 50:279-84.

Ravichandran D and Burge DM. Pneumonia presenting with acute abdominal pain in children. Br J Surg 1996;83:1707-8.

Kanegaye JT and Harley JR. Pneumonia in unexpected locations: an occult cause of pediatric abdominal pain. J Emerg Med 1995;13:773-9.

Janssen LJF, Voorhoeve PG, van den Wildenberg FJH, van den Brand LRCL. Acute abdominal pain in children caused by pneumonia. Ned Tijdschr Geneeskd 2016;160:D533.

Fotsch DM, Fox J, Snedden TR. Unexpected pneumonia diagnosis from pediatric abdominal pain: A case report. J Pediatr Health Care 2022;36:170-3.

Tsalkidis A, Gardikis S, Cassimos D, Kambouri K, Tsalkidou E, Deftereos S, et al. Acute abdomen in children due to extra-abdominal causes. Pediatr Int 2008;50:315-8.

Hyams JS, Lorenzo CD, Saps M, Shulman RJ, Staiano A, van Tilburg M. Childhood Functional Gastrointestinal Disorders: Child/ Adolescent. Gastroenterol 2016;150:1456-68.

Choi JY, Ryoo E, Jo JH. Risk factors of delayed diagnosis of acute appendicitis in children: for early detection of acute appendicitis. Korean J Pediatr 2016;59:368-73.

Vignault F, Filiatrault D, Brandt ML, Garel L, Grignon A, Ouimet A. Acute appendicitis in children: evaluation with US. Radiology 1990;176:501-4.

Downloads

Published

2024-04-30

How to Cite

1.
Pornsiripratharn W. Etiology of Acute Abdominal Pain in Children Hospitalized in The General Pediatric Ward. udhhosmj [internet]. 2024 Apr. 30 [cited 2025 Dec. 13];32(1):84-98. available from: https://he02.tci-thaijo.org/index.php/udhhosmj/article/view/269017

Issue

Section

Research Article