Prevalence And Predictive Factors of Advanced Cholangiocarcinoma Patient in Chemotherapy Treatment

Abstract

Cholangiocarcinoma is one of the health problem in Thailand, commonly found in North-Eastern and Northern province, usually present with unresectable disease which need systemic chemotherapy for treatment. The poor prognosis of this cancer most present with late presentation with unresectable disease, the limited systemic chemotherapy regimen. The purpose of this study was to find incidence rate of disease control group in patients who received treatment in Udonthani hospital during year 2017-2021. In this retrospective cohort study, sampling were advanced cholangiocarcinoma patients who received chemotherapy treatment at Udonthani hospital during year 2017-2021. Data collected from medical records. Statistical analysis used descriptive and logistic regression.

Results show 95 patients had disease control 31 patients(32.6%) and 64 patients in no response group(67.4%). Predictive factors of disease control response evaluate by univariate logistic regression found ECOG performance status ( odd ratio 4.1 for ECOG 0 vs ECOG 1-3), stage of disease (odd ratio 6.0 for locally advanced vs metastatic disease) and site of disease (  odd ratio 5.96 compared extrahepatic vs intrahepatic); after evaluate with multivariable logistic regression found 2 factors; stage of disease (adjusted odd ratio 6.17 for locally advanced vs metastasis) and site of disease (adjusted odd ratio 6.48 for extrahepatic vs intrahepatic) were predictive factors for response to chemotherapy.