The Study of 30-Day Mortality Rate of The Complete Hour-1 Sepsis Bundle in The Emergency Department, Prasat Hospital.

Abstract

Sepsis is a life-threatening condition and a major global public health issue due to its severe progression and relatively high mortality rate. The Surviving Sepsis Campaign recommends that all interventions be completed within one hour, with the expectation that early treatment will help reduce mortality rates. However, there is currently no empirical evidence supporting this assumption. The aim of this study was to compare the outcomes of the hour-1 sepsis bundle on the rates of shock and 30-day mortality in patients with bloodstream infections admitted to the emergency department of Prasat Hospital. The study used a retrospective design, reviewing patient records from October 2022 to September 2023 of 112 patients with bloodstream infections who were treated at the emergency department of Prasat Hospital. The data were analyzed using descriptive statistics, percentage calculations, mean values, and Chi-square,              t test, logistic regression.                                             

Results: Among the 112 patients, 69.6% were male, and 28.6% died within 30 days. Following the hour-1 sepsis bundle, 58 patients (51.8%) fully complied with the protocol. Shock occurred in 50 patients (44.6%) within six hours of treatment. The 30-day mortality rates for those who fully complied and those who did not comply with the hour-1 sepsis bundle within one hour were 19.0% and 38.9%, respectively. The group that did not adhere to the hour-1 sepsis bundle within one hour had a 2.72 times higher risk of 30-day mortality compared to the fully compliant group (odds ratio=2.72, 95% CI; 1.16-6.39, p = 0.034).

Conclusion: Adherence to the hour-1 sepsis bundle significantly affects the 30-day mortality rate. Full implementation of the sepsis bundle is associated with a lower mortality rate in patients diagnosed with sepsis syndrome.