ปัจจัยที่ทำให้ผู้ป่วยภาวะพิษเหตุติดเชื้อเสียชีวิต โรงพยาบาลเพ็ญ จังหวัดอุดรธานี

Nattapol  Chuyingsakultip

Authors

Nattapol Chuyingsakultip Internal medicine, Phen Hospital, Udonthani

Keywords:

sepsis, septic shock, mortality rate

Abstract

Sepsis is a dangerous emergency caused by infection which causes the body respond to inflammation, resulting in tissue hypoperfusion and multiple organ failure, with various consequences, patients may die or develop complications, have longer stays in hospital, higher rates of re-hospitalizations and higher medical expense. Worldwide, there is a high incident of sepsis and the mortality rate is likely to increase. This was a retrospective cohort study aimed to study the factors that caused the death of patients with sepsis. Data collection from medical record of patients diagnosed with sepsis and had admitted as inpatients at Phen hospital, Udonthani province from October 1^st, 2022, to September 30^th, 2023.

Result: 243 patients with sepsis were included, the majority were male 56.4% with the average age of 61.96 years old. The source of infection was mostly from bloodstream infection 132 (54.3%) and the bacteria type mostly found in bloodstream infection was Escherichia coli 55.3%. The mortality rate of sepsis was 30.5% and the septic shock mortality rate was 86.5%. From the multiple regression analytics found the statistical significance factor that caused the death of patients with sepsis were cirrhosis (AOR 8.32, 95%CI: 1.96-35.36, p=0.004), skin or soft tissue infection (AOR 4.50, 95%CI:1.48-13.67, p=0.008), septic shock (AOR 5.82, 95%CI: 2.65-12.79, p<0.001) and Burkholderia pseudomallei septicaemia (AOR 4.88, 95%CI: 1.46-16.31, p = 0.010).

Conclusion: From this study, the mortality rate of sepsis was 30.5% and the mortality rate of septic shock was 86.5%. The significance factor that caused the death of patients with sepsis were cirrhosis, skin or soft tissue infection, septic shock and Burkholderia pseudomallei septicaemia.

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