The Efficacy of Mindfulness-Based Applications for Depression and Anxiety in Adults: A Meta-Analysis of Randomized Controlled Trials

Authors

  • Woraporn Supaprasith Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

mindfulness-based intervention applications, anxiety, depression, smartphone, adulthood, meta-analysis

Abstract

This study aimed to analyze the effect size of mindfulness-based intervention applications on anxiety and depression in adults. This research was a meta-analysis of randomized controlled trials (RCTs) comparing the efficacy of mindfulness-based intervention applications with various control conditions for depression and anxiety in adults. A systematic search was conducted in PubMed and Scopus for studies published between 2020 and February 2025. The meta-analysis included seven studies with total 3102 participants and the overall effect size was reported using Cohen’s d, comparing outcomes between the two groups at posttest.

          Results: The pooled effect size of mindfulness-based applications for depression was d = -0.58 (95% CI: -1.56, 0.39, p = 0.24, I2 =0.99), while for anxiety, it was d = -0.60 (95% CI: -1.82, 0.61, p = 0.33, I2 =1.00) with high heterogeneity and no statistically significant.

          Conclusion: The findings suggested that the pooled effect size of mindfulness-based intervention applications on depression and anxiety was moderate but no statistically significant. However, this study was limited by the small number of studies included, highlighting the need for further research in this area.

References

Mental health: World Health Organization. (internet) (access 2025.03.01) [Available from: https://www.who.int/health-topics/mental-health#tab=tab_2].

Eberth J, Sedlmeier P. The Effects of Mindfulness Meditation: A Meta-Analysis. Mindfulness. 2012;3(3):174-89.

Tang Y-Y, Hölzel BK, Posner MI. The neuroscience of mindfulness meditation. Nature Reviews Neuroscience. 2015;16(4):213-25.

Gál É, Ștefan S, Cristea IA. The efficacy of mindfulness meditation apps in enhancing users’ well-being and mental health related outcomes: a meta-analysis of randomized controlled trials. Journal of Affective Disorders. 2021;279:131-42.

Huberty J, Puzia ME, Green J, Vlisides-Henry RD, Larkey L, Irwin MR, et al. A mindfulness meditation mobile app improves depression and anxiety in adults with sleep disturbance: Analysis from a randomized controlled trial. General Hospital Psychiatry. 2021;73:30-7.

Flett JAM, Hayne H, Riordan BC, Thompson LM, Conner TS. Mobile Mindfulness Meditation: a Randomised Controlled Trial of the Effect of Two Popular Apps on Mental Health. Mindfulness. 2019;10(5):863-76.

Linardon J, Messer M, Goldberg SB, Fuller-Tyszkiewicz M. The efficacy of mindfulness apps on symptoms of depression and anxiety: An updated meta-analysis of randomized controlled trials. Clin Psychol Rev. 2024;107:102370.

Gál É, Ștefan S, Cristea IA. The efficacy of mindfulness meditation apps in enhancing users' well-being and mental health related outcomes: a meta-analysis of randomized controlled trials. J Affect Disord. 2021;279:131-42.

Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Routledge; 1988.

Choi GJ, Kang H. Heterogeneity in meta-analyses: an unavoidable challenge worth exploring. Korean J Anesthesiol. 2025 Aug;78(4):301-314. doi: 10.4097/kja.25001. Epub 2025 Feb 14. PMID: 39956636; PMCID: PMC12326561.

Rocamora González C, Rodríguez Vega B, Torrijos Zarcero M, Mediavilla R, Bouzó Molina N, Plaza Fernández R, et al. Mindfulness based intervention through mobile app for colorectal cancer people awaiting surgery: A randomized clinical trial. Cir Esp (Engl Ed). 2022;100(12):747-54.

Taylor H, Cavanagh K, Field AP, Strauss C. Health Care Workers' Need for Headspace: Findings From a Multisite Definitive Randomized Controlled Trial of an Unguided Digital Mindfulness-Based Self-help App to Reduce Healthcare Worker Stress. JMIR Mhealth Uhealth. 2022;10(8):e31744.

Zhao C, Zhao Z, Levin ME, Lai L, Shi C, Hu J, et al. Efficacy and acceptability of mobile application-delivered acceptance and commitment therapy for posttraumatic stress disorder in China: A randomized controlled trial. Behav Res Ther. 2023;171:104440.

Cox CE, Gallis JA, Olsen MK, Porter LS, Gremore T, Greeson JM, et al. Mobile Mindfulness Intervention for Psychological Distress Among Intensive Care Unit Survivors: A Randomized Clinical Trial. JAMA Intern Med. 2024;184(7):749-59.

Horwitz AG, Mills ED, Sen S, Bohnert ASB. Comparative Effectiveness of Three Digital Interventions for Adults Seeking Psychiatric Services: A Randomized Clinical Trial. JAMA Netw Open. 2024;7(7):e2422115.

Zainal NH, Tan HH, Hong RY, Newman MG. Is a brief mindfulness ecological momentary intervention more efficacious than a self-monitoring app for social anxiety disorder? A randomized controlled trial. J Anxiety Disord. 2024;104:102858.

Renn BN, Walker TJ, Edds B, Roots M, Raue PJ. Naturalistic use of a digital mental health intervention for depression and anxiety: A randomized clinical trial. Journal of Affective Disorders. 2025;368:429-38.

Chen B, Yang T, Xiao L, Xu C, Zhu C. Effects of Mobile Mindfulness Meditation on the Mental Health of University Students: Systematic Review and Meta-analysis. J Med Internet Res. 2023;25:e39128.

Plaza I, Demarzo MMP, Herrera-Mercadal P, García-Campayo J. Mindfulness-Based Mobile Applications: Literature Review and Analysis of Current Features. JMIR Mhealth Uhealth. 2013;1(2):e24.

Downloads

Published

2025-12-29

How to Cite

1.
Supaprasith W. The Efficacy of Mindfulness-Based Applications for Depression and Anxiety in Adults: A Meta-Analysis of Randomized Controlled Trials. udhhosmj [internet]. 2025 Dec. 29 [cited 2026 Feb. 8];33(3):464-72. available from: https://he02.tci-thaijo.org/index.php/udhhosmj/article/view/279572