Drug Resistance Testing of HIV Patients/Aids Antiviral HIV Drugs Treatment at Roi Et Hosptival: A Retrospective Study
Keywords:HIV patients/Aids, HIV-Viral load, HIV-Drug Resistance
The objective of this retrospective descriptive study was to study the result of drug resistance testing among HIV/AIDS patients receiving antiviral HIV drugs treatment. The study subjects were HIV/ADIS patients having HIV-Viral Load (VL) >1,000 copies/mL. The data was collected by the molecular laboratory at Roi Et Hospital between January 1st, 2016 to December 31st, 2018. The data was analyzed using descriptive statistics. The results showed that two-thirds of patient were males (64.36%), average age 35.09 years (SD = 11.23). The average HIV-VL was 102,795.6 copies/mL (±SD 215,831.6). Two-thirds of subjects had drug resistance (68.88%) consisting of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) (45.21%), Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) (65.69%), and Protease Inhibitors (PIs) (3.99%). It showed that all of them susceptible to Integrase strand transfer Inhibitors (INSTIs) (100%) and resistance to NRTIs (1.44%), NNRTIs (2.09%) and PIs (0.13%). It was found that there was non-resistance to INSTIs drug. In summary, most patients had drug resistant to NNRTIs, NRTIs
and Pls and susceptible to INSTIs
UNAIDS_FactSheet_en.pdf [Internet]. [cited 2020 Apr 16]. Available from: https://www.unaids.org/sites/default/files/mediaasset/UNAIDS_FactSheet_en.pdf.
E-Document [Internet]. [cited 2020 Apr 16]. Available from: http://aidssti.ddc.moph.go.th/contents/view/60?page=2.
Thai Civil Rights and Investigative Journalism (TCIJ). [cited 2020 Apr 16]. Available from: https://www.tcijthai.com/news/2019/10/scoop/9565.
Yingyos, P. Educational Achievement of Anti-Retroviral Drugs in Anonymous Clinics at Somdej Prasankharat Hospital, Pra Nakhon Si Ayutthaya Province. J Prev Med Assoc Thai 2014; 4: 185–93. (In Thai)
HIV guideline 2557. [Internet]. [cited 2020 Apr 16]. Available from: http://www.thaiaidssociety.org/images/PDF/hivguideline2557.pdf.
AIDS. [Internet]. [cited 2020 Apr 16]. Available from: https://www.disthai.com.
HIV. In: Wikipedia [Internet]. 2020. Available from: https://en.wikipedia.org/w/index.php?title=HIV&oldid=950470393.
AIDS. In: Wikipedia [Internet]. 2020. Available from: https://th.wikipedia.org/w/index.php?.
Jinasen, R. Situation of HIV Infection and ARV Treatment in HIV Infection/AIDS Patient Analysis in Chiangrai Prachanukroh Hospital, Chiangrai Province. Thai AIDS J 2018; 30: 57–68. (In Thai)
Jenwitheesuk, E., Watitpun, C., Vibhagool A., Chantratita, W. Prevalence of genotypic HIV-1 drug resistance in Thailand, 2002. Ann Clin Microbiol Antimicrob. 2003; 2(1): 4.
Sukasem, C., Churdboonchart, V., Chasombat, S., Kohreanudom, S., Watitpun, C., Pasomsub, E., et al. Surveillance of Genotypic Resistance Mutations in Chronic HIV-1 Treated Individuals After Completion of the National Access to Antiretroviral Program in Thailand. Infection 2007; 35(2): 81.