Factors Associated with Endothelial Cell Functions and Arterial Stiffness in Elderly
Keywords:Elderly, Arterial stiffness, Endothelial function
This study aimed to investigate the factors associated with endothelial cell functions and arterial stiffness in elderly. Sixty-eight subjects aged 60-80 years were voluntarily enrolled. Data were collected for factors such as age, gender, waist circumference, body mass index, mean blood pressure, heart rate, underlying disease, family history of cardiovascular disease, smoking history, drinking history, and physical activity by using a validated questionnaire and arterial stiffness was evaluated by using cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) and endothelial function was determined by using flow-mediated vasodilation (FMD). Data were analyzed using descriptive statistics and multiple linear regression. The results showed that age, underlying disease, and body mass index (BMI) significantly predict CAVI at approximately 21% (R2=0.210, F = 6.954, p < 0.05); family history of cardiovascular disease, drinking history, and mean arterial blood pressure significantly predict ABI at approximately 23.9% (R2=0.239, F = 8.005, p < 0.05), and heart rate, physical activity with high metabolic equivalent of task (MET) significantly predict FMD at approximately 22.7% (R2=0.227, F = 9.819, p < 0.05). Interestingly, the positive correlation between high MET and FMD may imply that exercise in aging prevented age-induced endothelial dysfunction.
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