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This quasi-experimental research aimed to investigate the effects of interactive e-games on the health of students and compare the students’ physical fitness before and after participating in the physical activities in interactive e-games. The population in this study was 27 men of Mechatronics Engineering students, Year 2 of College of Integrated Science and Technology, Rajamangala University of Technology Lanna. Data analysis using descriptive statistics, using average and standard deviation, The results of pre and post of training physical fitness tests were compared using a Paired-sample t-test. The results showed that: Interactive game activity programs can improve physical performance., The results indicated that at the end of the training the overall physical fitness had higher mean scores, statistically significant at 0.05. The details showed that the leg strength performance post-test had higher from pre-test (p-value = 0.026), flexibility performance post-test had higher from pre-test (p-value < 0.001), lung capacity performance post-test had higher from pre-test (p-value = 0.005), oxygen consumption performance post-test had higher from pre-test (p-value = 0.024). However, the body fat performance and grip strength performance (p-value = 0.863) and (p-value = 0.463) after training were not different from before training.
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