Incidence and Risk Factors of Retinopathy of Prematurity among Very Low Birth Weight Infants in the Neonatal Intensive Care Unit

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Chitlada Phenglai
Chiraphon Aura
Wasana Lavin


Retinopathy of Prematurity (ROP) is a complication commonly found in very low birth weight infants. The purpose of this research was to study the incidence and risk factors related to ROP among 39 premature infants weighing less than 1,500 grams in the Neonatal Intensive Care Unit of Ramathibodi Chakri Naruebodindra Hospital. Analytical statistics used for data analysis were frequency, percentage, mean, median and standard deviation. The statistical tests used in this study were fisher's exact test and chi-square test for finding the relationship which association with ROP. The study was conducted from 1 October 2019 - 31 December 2021. The study found that there were 12 ROP cases (30.77%). The factors significantly causing the ROP were birth weight 1,000 grams, Odds Ratio (OR) for 8.50 times (95% CI, 1.54-46.87; p-value = 0.014) when compared with infants

weighing >1,000 grams. For a gestational age, it was found that those with a gestational age of 23-25 ​​weeks had a significantly higher risk of complications 33 times (95% CI, 2.45-443.61; p-value = 0.004). Therefore, the occurrence of ROP in prematurity, especially in very low birth weight infants, can be prevented by providing prenatal care as soon as a woman finds out she is pregnant, preventing preterm birth, obtaining medical assistance immediately after a premature birth, and providing the appropriate neonatal care. The study findings will also lead to the quality improvement of nursing care.

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Phenglai C, Aura C, Lavin W. Incidence and Risk Factors of Retinopathy of Prematurity among Very Low Birth Weight Infants in the Neonatal Intensive Care Unit. Health Sci J Thai [Internet]. 2024 Jun. 10 [cited 2024 Jul. 14];6(2):40-7. Available from:
Original articles


Poovichayasumlit C. Retinopathy of prematurity at Thammasat University Hospital. Thammasat Medical Journal. 2020; 20(4): 297-360.

Fierson WM. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2018; 112(6): 1-9.

Stahl A, Marlow N, Martinez-catellanos MA. Retinopathy of prematurity: Transforming treatment paradigms. Supplement to retina today. 2020:1-8.

Daopalangphrom S, Intachumpoo J. Clinical characteristics of retinopathy of prematurity in Chiangrai Prachanukroh hospital. Thai Pediatric Journal. 2021; 60(1): 38-46. (In Thai)

Saleewan K. Incidence and risk factors of retinopathy of prematurity (ROP). Medical Journal of Srisaket Surin Buriram Hospital 2016; 31(2): 99-110. (In Thai)

Hong EH, Shin YU, Bae GH, Choi YJ, Joonahn S, Sobrin L, et al. Nationwide incidence and treatment pattern of retinopathy of prematurity in South Korea using the 2007-2018 national health insurance claims data. Scientifc reports. 2021; 11(1): 1-11.

Siswanto JE, Bos A, Dijk PH, Rohsiswatmo R, Irawan G, Sulistijono E, et al. Multicentre survey of retinopathy of prematurity in Indonesia. BMJ Paediatrics Open. 2021; 5: e000761: 1-8.

Chen Y, Xun D, Wang YC, Wang B, Geng SH, Chen H, et al. Incidence and risk factors of retinopathy of prematurity in two neonatal intensive care units in North and South China. Chinese Medical Journal. 2015; 128(7) :914-8.

Thakre S, Deshmukh P, Kalyanshetti G, Mishrikotkar J. Incidence, severity, and risk factors of retinopathy of prematurity in central Maharashtra, India. Perinatology. 2017; 18(2): 50-5.

Leng Y, Huang W, Ren G, Cai C, Tan Q, Liang Y, et al.The treatment and risk factors of retinopathy of prematurity in neonatal intensive care units. BMC Ophthalmology 2018; 18(301): 1-8.

Hwang JH, Lee EH, Kim EA. Retinopathy of prematurity among Very-Low-Birth-Weight infants in Korea: Incidence, treatment, and risk factors. Journal Korean Medical Science. 2015; 30: S88-94.

Braimah IZ, Enweronu-Laryea C, Sackey AH, Kenu E, Agyabeng K, Ofori-Adjei IO, et al. Incidence and risk factors of retinopathy of prematurity in Korle-Bu Teaching Hospital: a baseline prospective study. BMJ Open. 2020; 10: 1-11.

Quinn GE, Ying GS, Bell EF, Donohue PK, Morrison D, Tomlinson LA, et al. Incidence and early course of retinopathy of prematurity secondary analysis of the postnatal growth and retinopathy of prematurity (G-ROP) study. JAMA Ophthalmology. 2018;136(12):1383-9.

Han LS, Bedggood A. Incidence of retinopathy of prematurity in Christchurch hospital, New Zealand over a 10-year period.New Zeland Medication association journal. 2019; 132(1495): 23-9.

Podraza W, Michalczuk B, Jezierska K, Domek H, Kordek A, Loniewska B, et al.Correlation of retinopathy of prematurity with bronchopulmonary dysplasia. Open Medicine. 2018; 13: 67-73.

Dani C, Coviello C, Panin F, Frosini S, Costa S, Purcaro V, et al. Incidence and risk factors of retinopathy of prematurity in an Italian cohort of preterm infants. Italian journal of pediatrics. 2021; 47(64): 1-6.

Kim SJ, Port AD, Swan R, J. Campbell P, Paul Chan RV, Chiang MF. Retinopathy of Prematurity:A review of risk factors and their clinical significance.Survey Ophthalmology. 2018; 63(5):6 18-37.

Gileles-Hillel A, Erlichman I, Reiter J. Apnea of prematurity: An update. Journal of child science. 2019; 9(1): e50-8.

Gomaa NAS, Helmy YA, Maher S, Hassanein D, Shuaib A, Hegazy AI, et al. Clinical characteristics of preterm neonates with aggressive posterior retinopathy of prematurity. Clinical Ophthalmology. 2021; 15: 2263-77.

Rashtriya Bal Swasthya Karyakram. Ministry of health and family welfare government of India. Guidelines for universal eye screening in newborns including retinopathy of prematurity. [Internet]. 2016 [Cited on 1 March 2022]. Available from: https://www.Nhm.



Royal college of paediatrics and child health. UK screening of retinopathy of prematurity guideline. Summary of recommendations. [Internet] 2022 [Cited on 1 June 2022]. Available from: guideline% 20summary%20 June.pdf.

Ramirez ND, LuqueAranda G, Diaz FR, Frias FJ, Tamayo TS. Risk factors associated with retinopathy of prematurity development and progression.Scientifc Reports. 2022; 12(21977): 1-9.

Blencowe H, Lawn JE, Vazquez T, Fielder A, Gilbert C. Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010. Pediatric research. 2013; 74(1): 35-49.

Ryu J. New aspects on the treatment of retinopathy of prematurity: Currently available therapies and emerging novel therapeutics. International journal of Molecular sciences. 2022; 23(15): 1-18.

Yu CW, Popovic MM, Dhoot AS, Arjmand PR, Muni RH, Tehrani NN, et al. Demographic risk Factors of retinopathy of prematurity: A systematic review of population based studies. Neonatology. 2022; 119: 151–63.

Uchida A, Miwa M, Shinoda H, Koto T, Nagai N, Mochimaru H, et al. Association of maternal age to development and progression of retinopathy of prematurity in Iifants of gestational age under 33 weeks. Journal of Ophthalmology 2014; 187929: 1–6.