Outcomes of Patient Care and Factors Associated with the Complications in Very Low Birth Weight Preterm Infants in the Neonatal Intensive Care Unit
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Abstract
This retrospective study determined the outcomes and associated factors with complications among very low birth weight preterm infants (VLBW) in the neonatal intensive care unit at Ramathibodi Chakri Naruebodindra Hospital. A total of 64 newborns with birth weight ≤ 1,500 grams and gestational age ≤ 32 weeks were included from January 1, 2019 to June 30, 2022. The statistics used for data analysis were percentage, mean, and standard deviation of mean. The Chi-square and Fisher's exact test were used for analysis of relationship between the complications. The results showed that a number of baby survivors were 70.31%. The complications were found 33 cases (51.56%). The most common complications were respiratory distress syndrome (92.19%), bronchopulmonary dysplasia (65.63%), and jaundice (81.25%). The related factors with the complications were birth weight and blood transfusions (p-value= 0.003 and 0.013, respectively). This research findings indicated that the VLBW group had a high mortality and complication rate.
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References
World Health Organization (WHO). Preterm birth. [Internet] 2022 [Cited in 30 July, 2022]. Available from: https://www.who.int/news-room/fact-sheets/detail/preterm-birth.
World Health Organization (WHO). Ending preventable newborn deaths and stillbirths by 2030: Moving faster towards high-quality universal health coverage in 2020–2025 July 2020. [Internet] 2022 [Cited in 30 July, 2022]. Available from: https://www.unicef.org/media/77166/file/Ending-preventable-newborn-deaths-and-stillbirths-by-2030-universal-health-coverage-in-2020%E2%80%932025.pdf.
Osterman MJK, Hamilton BE, Martin JA, Driscoll AK, Valenzuela CP. Births: Final Data for 2020. National Vital Statistics Reports 2022; 70(17): 1-50.
Marlow N. Outcomes of preterm birth and evidence synthesis. Dev Med Child Neurol 2018; 60(4): 330.
Sangkla N. Mortality and prognosis of very low birth weight infants: 6 years review. Med J Srisaket Surin 2021; 36(1): 207-17.
Udomsup J. Trends in Neonatal Mortality at Chaiyaphum Hospital, 2012-2019 Srinagarind Med J 2021; 36(4): 416-424. (in Thai)
Choocherd P. Incidence and factor associated with mortality of very low birth weight infants in Chaophrayayommarat hospital. Reg 4-5 Med J 2021; 40(4): 529–38. (in Thai)
Bello M, Pius S, Ibrahim BA. Characteristics and predictor of outcome of care of preterm newborns in resource constraints setting, Maiduguri, Northeastern Nigeria. J. Clin. Neonatol 2019; 8(1): 39-46.
Cordeiro RC, Ferreira DM, Reisa HD, Azevedo VM, Protaziob ADS, Abdallah VO, et al. Hypothermia and neonatal morbi-mortality in very low birth weight preterm infants. Rev Paul Pediatr 2022; 40: e2020349: 1-8.
Tanthawat S. Outcome of very low birth weight infants in Udonthani hospital. Udhhosmj 2017; 25(3): 241-48.
Lee HC, Liu J, Profit J, Hintz SR, Gould JB. Survival without major morbidity among very low birth weight infants in California. J. Pediatr 2020; 146(1): e20193865: 1-10.
Cavallo MC, Gugiatti A, Fattore G, Gerzeli S, Barbieri D, Zanini R, et al. Cost of care and social consequences of very low birth weight infants without premature- related morbidities in Italy. Ital. J. Pediatr 2015; 41(59): 1-12.
Simon LV, Hashmi MF, Bragg BN. Apgar score. Treasure Island: StatPearls Publishing; 2023.
Autjimanon H, Kerdsuk S. Factors Associated with Neonatal Mortality in Neonatal Intensive Care Unit of King Narai Hospital. JPMAT 2022; 12(1): 100-15.
Kanthasup S, Soonpayanon S. Development of Care Systems for Premature Infants in Phra Nakhon Si Ayutthaya Hospital and Networks. JPMAT 2015; 5(1): 1-14. (in Thai)
Ruangphraya T, Jenjarat K. Outcomes of very low birth weight preterm infants at Nakornping hospital. J Nakornping Hosp 2021; 12(2): 32-49. (in Thai)
Ingemyr K, Elfvin A, Hentz E, Saggers RT, Ballot DE. Factors influencing survival and short-term outcomes of very low birth weight infants in a tertiary hospital in Johannesburg. Front. Pediatr 2022; 10(930338): 1-9.
Michaelis IA, Krageloh-Mann I, Manyisane N, Mazinu MC, Jordaan ER. Prospective cohort study of mortality in very low birthweight infants in a single centre in the Eastern Cape Province, South Africa. BMJ Paediatr. Open 2021; 5(e000918): 1-7.
Ntuli TS, Shipalana N, Hamese MHK. Factors associated with preterm very low birthweight infant mortality at a tertiary hospital in Limpopo Province, South Africa. S Afr J Child Health 2020; 14(1): 10-14.
Hirata K, Kimura T, Hirano S, Wada K, Kusuda S, Fujimura M. Outcomes of outborn very-low-birth-weight infants in Japan. Arch Dis Child Fetal Neonatal Ed 2021; 106: F131-6.
Walsh MC, Bell EF, Kandefer S, Saha S, Carlo WA, Dangio CT, et al. Neonatal outcomes of moderately preterm infants compared to extremely preterm infants. Pediatr Res 2017; 82(2): 297-304.
Yu CW, Popovic MM, Dhoot AS, Arjmand PR, Muni RH, Tehrani NN, et al. Demographic risk factors of retinopathy of prematurity: A systematic review of population based studies. Neonatology 2022; 119(2): 151–63.
Kirpalani H, Whyte RK, Andersen C, Asztalos EV, Heddle N, Blajchman MA, et al. The premature infants in need of transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006; 149: 301-7.
Uberos J, Fernandez-Marin E, Campos-Martinez A, Ruiz-Lopez A, Garcia-Serrano JL. Blood products transfusion and retinopathy of prematurity: A cohort study. Acta Ophthalmol 2022; 101: e294–301.
Duan J, Kong X, Li O, Hua S, Zhang S, Zhang X, et al. Association between anemia and bronchopulmonary dysplasia in preterm infants. Sci Rep 2016; 6(22717): 1-6.
Colombatti R, Sainati L, Trevisanuto D. Anemia and transfusion in the neonate. Semin Fetal Neonatal Med 2016; 21(1): 2–9.
Zhang Z, Huang X, Lu H. Association between red blood cell transfusion and bronchopulmonary dysplasia in preterm infants. Sci Rep 2014; 4(4340): 1-5.