Validity and Reliability of the Health-Related Quality of Life Instrument for End Stage Renal Disease Patients undergoing Dialysis: A Modified Version

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Noppawan Phinitkhajorndech
Soracha Wanichmontri
Orasa Panpakdee


This study aimed to modify and test the validity and reliability of the Thai Health-Related Quality of Life Instrument for Dialysis Patients (THAI-HRQOL-D),developed by the researchers in 2012. The sample for testing the validity and reliability of the instrument consisted of 244 participants undergoing dialysis (185 hemodialysis
and 59 peritoneal dialysis patients) who attended four dialysis centers in the eastern region of Thailand. The construct validity of the instrument was determined through exploratory and confirmatory factor analyses and the known-groups technique. Also,Cronbach’s alpha coefficients were used to test the internal consistency reliability of the instrument. The results yielded seven factors and explained 52.89% of the variance.These seven factors, consisting of 34 items, included health and functioning, living with symptoms, living with dialysis, socioeconomics and family, spirituality, psychological
well-being, and cognition. Through the confirmatory factor analysis, the adequate relative goodness of fit indices revealed that the measurement model fit the data. The internal consistency reliability, measured by Cronbach’s alpha coefficients, was good. The known-groups technique revealed that participants with a normal level of hematocrit
and serum albumin had a significantly higher mean score of the THAI-HRQOL-D than those with a low level. This study demonstrated that this disease-specific instrument has adequate validity and reliability to assess health-related quality of life among dialysis patients.
Keywords: Health-related quality of life instrument, Validity, Reliability, End stage renal disease patients undergoing dialysis


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Phinitkhajorndech N, Wanichmontri ส, Panpakdee อ. Validity and Reliability of the Health-Related Quality of Life Instrument for End Stage Renal Disease Patients undergoing Dialysis: A Modified Version. Rama Nurs J [Internet]. 2022 Apr. 22 [cited 2022 Jul. 3];28(1):1-15. Available from:
Author Biography

Soracha Wanichmontri, Phrapokklao Nursing College, Faculty of Nursing, Praboromrajchanok Institute

Department of Adult and Gerontological Nursing, Phrapokklao Nursing College, Faculty of Nursing, Praboromrajchanok Institute



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