Unilateral Angiolymphoid Hyperplasia with Eosinophilia of the Right Upper Extremity: a reported case

Authors

  • Supaporn Siripun INSTITUTE OF DERMATOLOGY, MINISTRY OF PUBLIC HEALTH, BANGKOK, THAILAND
  • Pornchai Pothinamthong INSTITUTE OF DERMATOLOGY, MINISTRY OF PUBLIC HEALTH, BANGKOK, THAILAND
  • Somsak Towanabut INSTITUTE OF DERMATOLOGY, MINISTRY OF PUBLIC HEALTH, BANGKOK, THAILAND
  • Pinnaree Kattipathanapomg INSTITUTE OF DERMATOLOGY, MINISTRY OF PUBLIC HEALTH, BANGKOK, THAILAND

Keywords:

Angiolymphoid hyperplasia with eosinophilia (ALHE), vascular proliferative disease

Abstract

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disease with unknown etiology. The predilection sites are head and neck but uncommon on extremities.

We report a 36-year-old Thai female with multiple lesions of ALHE on her right upper extremity. She had high serum IgE level. The histopathology revealed typical findings of ALHE. The immunohistochemical staining was  positive for capillary  but  negative for lymphatic markers and HHV 8. No arteriovenous shunting was found.

References

Well GC, Whimster IW. Subcutaneous angiolymphoid hyperplasia with eosinophillia. Br J Dermatol 1969;81:1-15.

Chong WS, Thomas A, Goh CL. Kimura's disease and angiolymphoid hyperplasia with eosinophilia: two disease entities in the same patient: case report and review of the literature. Int J Dermatol 2006;45:139-145.

Olsen TG, Helwig EB. Angiolymphoid hyperplasia with eosinophilia. A clinicopathologic study of 116 patients. J Am Acad Dermatol. 1985;12:781-796.

Arnold M, Geilen CG, Coupland SE, Krengel S, Dippel E, Spröder J et al. Unilateral angiolymphoid hyperplasia with eosinophilia involving the left arm and hand. J Cutan Pathol. 1999;26:436-40.

Gyulai R, Kemény L, Adám E, Nagy F, Dobozy A. HHV8 DNA in angiolymphoid hyperplasia of the skin. Lancet 1996; 29;347:1837.

Imbing FD Jr, Viegas SF, Sánchez RL. Multiple angiolymphoid hyperplasia with eosinophilia of the hand: report of a case and review of the literature. Cutis 1996; 58: 345-348.

Cham E, Smoller BR, Lorber DA, Victor TA, Cibull TL. Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) arising on the extremities. J Cutan Pathol 2010; 37: 1045-52.

Aguilar A, Ambrojo P, Requena L, Olmos L, Sánchez Yus E. Angiolymphoid hyperplasia with eosinophilia limited to the vulva. Clin Exp Dermatol. 1990;15:65-67.

Ohmori S, Sugita K, Sawada Y, Hino R, Nakamura M, Tokura Y. Angiolymphoid hyperplasia with eosinophilia occurring on the penis. Eur J Dermatol 2010; 20: 545-546.

Bartralot R, Garcia-Patos V, Hueto J, Huguet P, Raspall G, Castells A. Angiolymphoid hyperplasia with eosinophilia affecting the oral mucosa: report of a case and a review of the literature. Br J Dermatol 1996; 134: 744-748.

Park Y, Chung J, Cho CG. Angiolymphoid hyperplasia with eosinophilia of the tongue: report of a case and review of the literature. Oral Oncol 2002; 38: 103-106.

Nomura K, Sasaki C, Murai T, Mitsuhashi Y, Sato S. Angiolymphoid hyperplasia with eosinophilia: successful treatment with indomethacin farnesil. Br J Dermatol1996; 134: 189-190.

Alcántara González J, Boixeda P, Truchuelo Díez MT, Pérez García B, Jaén Olasolo P. Angiolymphoid hyperplasia with eosinophilia treated with vascular laser. Lasers Med Sci 2011; 26: 285-290.

Cheney ML, Googe P, Bhatt S, Hibberd PL. Angiolymphoid hyperplasia with eosinophilia (histiocytoid hemangioma): evaluation of treatment options. Ann Otol Rhinol Laryngol 1993; 102: 303-308.

Oh CW, Kim KH. Is angiolymphoid hyperplasia with eosinophilia a benign vascular tumor? A case improved with oral isotretinoin. Dermatology 1998; 197: 189-191.

Mashiko M, Yokota K, Yamanaka Y, Furuya K. A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment. Br J Dermatol 2006; 154: 803-804.

Gencoglan G, Karaca S, Ertekin B. Angiolymphoid hyperplasia with eosinophilia successfully treated with imiquimod. A case report. Dermatology 2007; 215: 233-5.

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Published

2026-06-09

How to Cite

Siripun, S., Pothinamthong, P., Towanabut, S., & Kattipathanapomg, P. (2026). Unilateral Angiolymphoid Hyperplasia with Eosinophilia of the Right Upper Extremity: a reported case. Thai Journal of Dermatology, 29(2), 130–135. retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/282868

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Section

Case Report