Plasma DNA of Cancer Patients

บทคัดย่อ

Cancer can produce many different symptoms, some subtle and some not at all subtle. Some symptoms develop early in the course of cancer and are therefore important warning signs that should be evaluated by a doctor. Measurement of DNA concentration in the plasma of cancer patients and healthy subjects aimed to screening test for people in risk of cancer.  There were 200 subjects, 100 patients with cancers and 100 healthy subjects.  Nucleospin ® XS was used to extract DNA in plasma of both groups, and then Qubit fluorometer was used to measure DNA concentration. Our results show that there were significant associations between plasma DNA concentration of cancer patients.  The concentration of plasma DNA in cancer patients; 31.0 (20.0-72.0) ng/ml were higher  than plasma DNA concentration of healthy subjects; 75.0 (25.0-607.0) ng/ml. This study may be useful for further investigations in risk of cancer.