Efficacy of Gelfoam® with Platelet-rich plasma to repair the tympanic membrane perforation
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Abstract
Abstract
Background: The eardrum implant surgery at the outpatient department is preferable if the
perforation is small. Today's most interesting tympanic materials are Gelfoam® and Platelet-rich
plasma or PRP. PRP contains substances that aid in the repair of body tissues and aid in the healing
process of wounds. It is a safe, time-consuming and cost-effective solution, requires no anesthesia,
no hospitalization, and relatively few complications.
Objective: To determine the efficacy of TM perforation by Myringoplasty using Gelfoam® plated
PRP compared with Gelfoam® impregnated normal saline solution in terms of perforation of the
eardrum and the hearing after treatment.
Methods: Prospective Randomized Controlled Trial was conducted in patients undergoing
tympanic membranes surgery at an outpatient examination room, Department of
Otorhinolaryngology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University from February
7th, 2020 to February 6th, 2021. Participants were 18-75 years old, with eardrum perforation no
more than 3 mm, and no ear infection for at least 3 months. Patients were divided into two groups:
Patients who received the eardrum implant surgery with Gelfoam® dropped PRP and with Gelfoam®
dropped NSS. After the surgery, patients were followed up at 2,4,12 weeks.
Results: A total of 22 trial participants were female, 15 (68.2%) and 7 males (31.8%). The
participants had a mean age of 63.4 ± 9.87 years in the tympanic membrane reconstructive surgery
using Gelfoam® PRP drops, and mean age 54.75 ± 17.63 years. It was found that in the group that
had been closed the perforation of the eardrum using PRP dropped on Gelfoam® had a significantly
more successful tympanic perforation rate than in the tympanic membrane enema group using NSS dropped on Gelfoam® (70% and 16.7%, respectively), p-value = 0.027). The air-bone gap
decreased by 4.86 ± 6.31 (p-value = 0.02).
Conclusion: In the treatment of Tympanic membrane perforation using Gelfoam® and PRP in
myringoplasty to improve the closure of the tympanic membrane perforation and hearing of the
patient.
Keywords: Tympanic membrane perforation, Gelfoam®, Platelet-rich plasma
Article Details
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ต้นฉบับที่ส่งมาพิจารณายังวารสารหู คอ จมูก และใบหน้า จะต้องไม่อยู่ในการพิจารณาของวารสารอื่น ในขณะเดียวกันต้นฉบับที่จะส่งมาจะผ่านการอ่านโดยผู้ทรงคุณวุฒิ หากมีการวิจารณ์หรือแก้ไขจะส่งกลับไปให้ผู้เขียนตรวจสอบแก้ไขอีกครั้ง ต้นฉบับที่ผ่านการพิจารณาให้ลงตีพิมพ์ถือเป็นสมบัติของวารสารหู คอ จมูกและใบหน้า ไม่อาจนำไปลงตีพิมพ์ที่อื่นโดยไม่ได้รับอนุญาต
ตารางแผนภูมิ รูปภาพ หรือข้อความเกิน 100 คำที่คัดลอกมาจากบทความของผู้อื่น จะต้องมีใบยินยอมจากผู้เขียนหรือผู้ทรงลิขสิทธิ์นั้นๆ และใหร้ะบุกำกับไว้ในเนื้อเรื่องด้วย
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