The Sensitivity of pre-operative ultrasonography, sestamibi scintigraphy, and computed tomography localization in secondary hyperparathyroidism: Systematic Review.

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อรุณรัตน์ ดำเกลี้ยง พ.บ.


Background: The number of patient secondary hyperparathyroidism, that requires surgical treatment, has a tendency to increase. The main cause of surgical failure is the incomplete intraoperative identification of all parathyroid glands. The preoperative localization of parathyroid glands have been helpful in surgical planning. Ultrasound, Sestamibi scintigraphy and CT scan are common imaging for localized parathyroid glands.

Data sources: PubMed, the Cochrane Library, Clinical trials, and Science Direct.

Review methods: Articles of preoperative imaging for localization of parathyroid glands in secondary hyperparathyroidism which were published between 2012 and 2021, were screened. Critical Appraisal Tool of JBI 2020 was used to assess the quality of the articles included in the review.

Results: Of the 187 identified articles, 11 were included in the review. Most of articles (9/11) were retrospective cross-sectional study. Sensitivity of Ultrasound, Sestamibi scintigraphy and CT scan were 53.0-98.5%, 25.0-88.2% and 58.6-84.8% respectively. Every study showed sensitivity of ultrasound superior than sestamibi scintigraphy. Only two studies reported sensitivity of CT scan, a study showed equal sensitivity of ultrasound and another one showed sensitivity of CT scan inferior than ultrasound.

Conclusions: Ultrasonography is good choice for initial localize parathyroid glands in secondary hyperparathyroidism. Sestamibi scintigraphy and CT scan suggest for persistent or recurrent disease.

Keywords: Sensitivity, Ultrasound, Sestamibi scintigraphy, CT scan, Secondary hyperparathyroidism.


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อรุณรัตน์ ดำเกลี้ยง พ.บ. (2022). The Sensitivity of pre-operative ultrasonography, sestamibi scintigraphy, and computed tomography localization in secondary hyperparathyroidism: Systematic Review. Thai Journal of Otolaryngology Head and Neck Surgery, 23(1). Retrieved from
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