Intraoperative near-infrared navigation with indocyanine green predicts negative margins at final pathology of oral cavity squamous cell carcinoma in Rajavithi Hospital

Main Article Content

Somjin Chindavijak, MD
Rojana Yansomboon,

Abstract

Background: Mainstay treatment of oral cavity squamous cell carcinoma is wide excision the tumor with adequate margin for decrease local recurrence and increase survival.



Objective: To compare tumor margin in pathology from tumor surgery by near infra-red spectroscopy (NIR spectroscopy) combine with indocyanine green (ICG) intravenous injection group with the conventional group . And to estimate efficacy of the tool.


 


Method: This is a Quasi-Experimental study of surgical treatment in squamous cell carcinoma of oral cancer by ICG injection 6-8 hrs before surgery with intraoperative NIR spectroscopy examined the tumor and tumor bed during January 2023 to November 2024 . And retrospective data collection of oral cancer patients surgery by conventional method which surgeon controlled the tumor margin
during January 2020 and November 2023.


Result. 30 patients were performed surgery with NIR spectroscopy combine with ICG and 120 patient records of conventional method surgery were reviewed. The pathological report of surgical margin between the tool and the conventional method demonstrated no statistically significant difference (p = 0.325) .The sensitivity and specificity of this tool for positive margin were 100 percent and
30.8 percent respectively.



Conclusions: The NIR spectroscopy combined with ICG injection method for surgical margin is high sensitivity but low specificity. The studied results of the tumor margin of both groups do not statistically significant difference.



Keywords: Surgical margin, Indocyanine green, Near-infrared fluorescence imaging, Oral cancer

Article Details

How to Cite
Somjin Chindavijak, MD, & Yansomboon, R. (2024). Intraoperative near-infrared navigation with indocyanine green predicts negative margins at final pathology of oral cavity squamous cell carcinoma in Rajavithi Hospital. Thai Journal of Otolaryngology Head and Neck Surgery, 25(1), 15–22. Retrieved from https://he02.tci-thaijo.org/index.php/rcotJ/article/view/268610
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Reseach Articles

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