Intraoperative near-infrared navigation with indocyanine green predicts negative margins at final pathology of oral cavity squamous cell carcinoma in Rajavithi Hospital
Main Article Content
Abstract
Background: Mainstay treatment of oral cavity squamous cell carcinoma is wide excision the tumor with adequate margin for decrease local recurrence and increase survival.
Objective: To compare tumor margin in pathology from tumor surgery by near infra-red spectroscopy (NIR spectroscopy) combine with indocyanine green (ICG) intravenous injection group with the conventional group . And to estimate efficacy of the tool.
Method: This is a Quasi-Experimental study of surgical treatment in squamous cell carcinoma of oral cancer by ICG injection 6-8 hrs before surgery with intraoperative NIR spectroscopy examined the tumor and tumor bed during January 2023 to November 2024 . And retrospective data collection of oral cancer patients surgery by conventional method which surgeon controlled the tumor margin
during January 2020 and November 2023.
Result. 30 patients were performed surgery with NIR spectroscopy combine with ICG and 120 patient records of conventional method surgery were reviewed. The pathological report of surgical margin between the tool and the conventional method demonstrated no statistically significant difference (p = 0.325) .The sensitivity and specificity of this tool for positive margin were 100 percent and
30.8 percent respectively.
Conclusions: The NIR spectroscopy combined with ICG injection method for surgical margin is high sensitivity but low specificity. The studied results of the tumor margin of both groups do not statistically significant difference.
Keywords: Surgical margin, Indocyanine green, Near-infrared fluorescence imaging, Oral cancer
Article Details
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ต้นฉบับที่ส่งมาพิจารณายังวารสารหู คอ จมูก และใบหน้า จะต้องไม่อยู่ในการพิจารณาของวารสารอื่น ในขณะเดียวกันต้นฉบับที่จะส่งมาจะผ่านการอ่านโดยผู้ทรงคุณวุฒิ หากมีการวิจารณ์หรือแก้ไขจะส่งกลับไปให้ผู้เขียนตรวจสอบแก้ไขอีกครั้ง ต้นฉบับที่ผ่านการพิจารณาให้ลงตีพิมพ์ถือเป็นสมบัติของวารสารหู คอ จมูกและใบหน้า ไม่อาจนำไปลงตีพิมพ์ที่อื่นโดยไม่ได้รับอนุญาต
ตารางแผนภูมิ รูปภาพ หรือข้อความเกิน 100 คำที่คัดลอกมาจากบทความของผู้อื่น จะต้องมีใบยินยอมจากผู้เขียนหรือผู้ทรงลิขสิทธิ์นั้นๆ และใหร้ะบุกำกับไว้ในเนื้อเรื่องด้วย
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