Change in platelet count according to date of illness among pediatric dengue infection patients at Mae Sot Hospital, Tak Province

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Published: Jul 2, 2020
Keywords:
Pediatric dengue infection platelet tendency follow-up futility

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โสภณ อัศวพลังกูล
กลุ่มงานกุมารเวชกรรม, โรงพยาบาลแม่สอด, อ.แม่สอด, จ.ตาก
ศรีสุดา อัศวพลังกูล
หน่วยวิจัยคลินิก, กลุ่มการพยาบาล, โรงพยาบาลแม่สอด, อ.แม่สอด, จ.ตาก

Abstract

Objective: To investigate the pattern of change in platelet count among pediatric dengue patients.
Methods: This study was conducted in a provincial hospital to investigate pediatric dengue patients age of 0-15 year that had been admitted to pediatric ward between 1st January 2014 and 31st December 2018. Signs and symptoms, age, nationality, underlying diseases and lab results included complete blood count were retrospectively collected from patient database in the center. Descriptive study of baseline characteristics and proportional comparison of clinical presentation profiles among severity groups: Dengue fever, Dengue hemorrhagic fever and Dengue shock syndrome had been analyzed using Fisher exact probability test or chi-square test where applicable.  Change of platelet count and their trends among groups were analyzed and demonstrated using Kruskal-Wallis equality-of-populations rank test, multilevel analysis and post-estimation prediction with graphic illustration.
Results: Total of 909 pediatric dengue infection patient were admitted in our hospital. Patients were enrolled in the study comprising of dengue fever 171 cases, dengue hemorrhagic fever 667 cases and dengue shock syndrome 59 cases. Distribution of gender among 3 groups was not different. Thai were 5 times and 2 times more than other ethnic among dengue fever and dengue hemorrhagic fever groups (83.0% vs. 17.0% and 68.1% vs. 31.9% respectively). Contrariwise, this was about 1.5 times less than other ethnic among dengue shock syndrome group (61.0% vs. 39.0% respectively). Platelet tended to decline after the second day of illness and reach their minimum around 5th – 6th day. They recovered then to more than 50,000/µL and 100,000/µL around 7th and 9th day of illness respectively.
Conclusion: Although patient in DSS group had lower platelet count than in the DF and DHF group, platelet of all three group recovered to above 50,000/µL and 100,000/µL around 7th and 9th day of illness respectively.

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1.
อัศวพลังกูล โ, อัศวพลังกูล ศ. Change in platelet count according to date of illness among pediatric dengue infection patients at Mae Sot Hospital, Tak Province. Siriraj Med Bull [Internet]. 2020 Jul. 2 [cited 2024 Dec. 22];13(3):171-82. Available from: https://he02.tci-thaijo.org/index.php/simedbull/article/view/228388
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Vol. 13 No. 3 (2020): July - September
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Original Article
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

References

1. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7.
2. World Health Organization. Dengue: guidelines for diagnosis, treatment, prevention and control. New ed: WHO Press; 2009.
3. Endy TP, Anderson KB, Nisalak A, Yoon IK, Green S, Rothman AL, et al. Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis. 2011;5(3):e975.
4. World Health Organization. Dengue and severe dengue: World Health Organization; 2019 [updated April 15, 2019]. Available from: https://www.who.int/en/news-room/fact-sheets/detail/dengue-and-severe-dengue.
5. Centers for Disease Control and Prevention. Dengue Around the World 2019 [updated May 3, 2019. Available from: https://www.cdc.gov/dengue/areaswithrisk/around-the-world.html.
6. European Centre for Disease Prevention and Control. Local transmission of dengue fever in France and Spain – 2018 Stockholm: ECDC; 2018 [updated 22 October 2018. Available from: https://ecdc.europa.eu/sites/portal/files/documents/08-10-2018-RRA-Dengue-France.pdf.
7. Okada K, Morita R, Egawa K, Hirai Y, Kaida A, Shirano M, et al. Dengue Virus Type 1 Infection in Traveler Returning from Tanzania to Japan, 2019. Emerg Infect Dis. 2019;25(9):1782-4.
8. Schwartz E, Weld LH, Wilder-Smith A, von Sonnenburg F, Keystone JS, Kain KC, et al. Seasonality, annual trends, and characteristics of dengue among ill returned travelers, 1997-2006. Emerg Infect Dis. 2008;14(7):1081-8.
9. World Health Organization. Dengue fever – Réunion, France: World Health Organization; 2019 [updated 20 May 2019]. Available from: https://www.who.int/csr/don/20-may-2019-dengue-reunion/en/.
10. Ooi EE, Goh KT, Gubler DJ. Dengue prevention and 35 years of vector control in Singapore. Emerg Infect Dis. 2006;12(6):887-93.
11. Cabrera-Cortina JI, Sanchez-Valdez E, Cedas-DeLezama D, Ramirez-Gonzalez MD. Oral calcium administration attenuates thrombocytopenia in patients with dengue fever. Report of a pilot study. Proc West Pharmacol Soc. 2008;51:38-41.
12. Cuong HQ, Vu NT, Cazelles B, Boni MF, Thai KT, Rabaa MA, et al. Spatiotemporal dynamics of dengue epidemics, southern Vietnam. Emerg Infect Dis. 2013;19(6):945-53.
13. Silva-Caso W, Espinoza-Espiritu W, Espejo-Evaristo J, Carrillo-Ng H, Aguilar-Luis MA, Stimmler L, et al. Geographical distribution, evaluation of risk of dengue and its relationship with the El Nino Southern Oscillation in an endemic region of Peru between 2004 and 2015. BMC Res Notes. 2019;12(1):498.
14. Vincenti-Gonzalez MF, Tami A, Lizarazo EF, Grillet ME. ENSO-driven climate variability promotes periodic major outbreaks of dengue in Venezuela. Sci Rep. 2018;8(1):5727.
15. กรมอุตุนิยมวิทยา. ความรู้อุตุนิยมวิทยา: กรมอุตุนิยมวิทยา; 2562 [Available from: https://www.tmd.go.th/info/info.php?FileID=23.
16. Carrington LB, Armijos MV, Lambrechts L, Barker CM, Scott TW. Effects of fluctuating daily temperatures at critical thermal extremes on Aedes aegypti life-history traits. PLoS One. 2013;8(3):e58824.
17. Halstead SB, Scanlon JE, Umpaivit P, Udomsakdi S. Dengue and chikungunya virus infection in man in Thailand, 1962-1964. IV. Epidemiologic studies in the Bangkok metropolitan area. Am J Trop Med Hyg. 1969;18(6):997-1021.
18. Cummings DA, Iamsirithaworn S, Lessler JT, McDermott A, Prasanthong R, Nisalak A, et al. The impact of the demographic transition on dengue in Thailand: insights from a statistical analysis and mathematical modeling. PLoS Med. 2009;6(9):e1000139.
19. Thomas SJ, Endy TP, Rothman AL, Barrett AD. Flaviviruses (Dengue, Yellow Fever, Japaneses Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika). In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Volume 2. 8th ed. Canada: Elsevier; 2015. p. 1811-903.
20. Guzman MG, Harris E. Dengue. Lancet. 2015;385(9966):453-65.
21. Ly S, Fortas C, Duong V, Benmarhnia T, Sakuntabhai A, Paul R, et al. Asymptomatic Dengue Virus Infections, Cambodia, 2012-2013. Emerg Infect Dis. 2019;25(7):1354-62.
22. Buchy P, Peeling R. Laboratory diagnosis and diagnostic tests. In: World Health Organization, editor. Dengue: guidelines for diagnosis, treatment, prevention and control. New ed. France: WHO Press; 2009. p. 89-108.
23. สำนักโรคติดต่อนำโดยแมลง กรมควบคุมโรค กระทรวงสาธารณสุข. คู่มือวิชาการโรคติดเชื้อเดงกีและโรคไข้เลือดออกเดงกีด้านการแพทย์และสาธารณสุข ปี พ.ศ. ๒๕๕๘. สุภาวดี พวงสมบัติ, ธีราวดี กอพยัคฆินทร์, วราภรณ์ เอมะรุจิ, บรรณาธิการ. กรุงเทพฯ: สำนักพิมพ์อักษรกราฟฟิคแอนด์ดีไซน์; ๒๕๕๘. ๑๔๐ หน้า.
24. ศิริเพ็ญ กัลยาณรุจ, มุกดา หวังวีรวงศ์, วารุณี วัชรเสวี. ใน: แนวทางการวินิจฉัยและรักษาโรคไข้เลือดออกเดงกี ฉบับเฉลิมพระเกียรติ ๘๐ พรรษามหาราชินี.สถาบันสุขภาพเด็กแห่งชาติมหาราชินี กรมการแพทย์ กระทรวงสาธารณสุข. พิมพ์ครั้งที่ ๑: โรงพิมพ์องค์การทหารผ่านศึก; ๒๕๕๖. หน้า ๖๖.
25. Pongpan S, Wisitwong A, Tawichasri C, Patumanond J, Namwongprom S. Development of dengue infection severity score. ISRN Pediatr. 2013;2013:845876.
26. Carrington LB, Seifert SN, Willits NH, Lambrechts L, Scott TW. Large diurnal temperature fluctuations negatively influence Aedes aegypti (Diptera: Culicidae) life-history traits. J Med Entomol. 2013;50(1):43-51.
27. Anyamba A, Chretien JP, Britch SC, Soebiyanto RP, Small JL, Jepsen R, et al. Global Disease Outbreaks Associated with the 2015-2016 El Nino Event. Sci Rep. 2019;9(1):1930.
28. Ferede G, Tiruneh M, Abate E, Wondimeneh Y, Gadisa E, Howe R, et al. A study of clinical, hematological, and biochemical profiles of patients with dengue viral infections in Northwest Ethiopia: implications for patient management. BMC Infect Dis. 2018;18(1):616.
29. Guzman MG, Kouri G, Bravo J, Valdes L, Vazquez S, Halstead SB. Effect of age on outcome of secondary dengue 2 infections. Int J Infect Dis. 2002;6(2):118-24.
30. Hammond SN, Balmaseda A, Perez L, Tellez Y, Saborio SI, Mercado JC, et al. Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. Am J Trop Med Hyg. 2005;73(6):1063-70.
31. Mittal H, Faridi MMA, Arora SK, Patil R. Clinicohematological Profile and Platelet Trends in Children with Dengue During 2010 Epidemic in North India. The Indian Journal of Pediatrics. 2012;79(4):467-71.