Penicillin-allergic Pregnant Women with Syphilis: Flow of Management at Siriraj Hospital

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Chamard Wongsa
Mongkhon Sompornrattanaphan
Chenchit Chayachinda
Panadda Swasdimongkol
Torpong Thongngarm


Penicillin has been evidently the mainstay antibiotic for treating pregnant women with syphilis to eliminate congenital syphilis. One of the biggest challenges for obstetricians is that a number of patients report penicillin allergy. Penicillin desensitization has been recommended by many academic organizations, including the Center for Disease Control and Prevention. The procedure requires well-trained multidisciplinary care team which includes obstetricians, allergists, anesthesiologist, pharmacists and experienced nurses. The venue of desensitization should ideally be an intensive care unit where emergency resuscitation is always available. This article aims to demonstrate a model of management at Siriraj Hospital.



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Wongsa C, Sompornrattanaphan M, Chayachinda C, Swasdimongkol P, Thongngarm T. Penicillin-allergic Pregnant Women with Syphilis: Flow of Management at Siriraj Hospital . Siriraj Med Bull [Internet]. 2021 Oct. 1 [cited 2023 Dec. 5];14(4):62-73. Available from:
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