Liver Injury in COVID-19 Patients in Cohort Ward, Somdejphrajaotaksin Maharaj Hospital
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Abstract
Objective: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), or COVID-19 disease, can lead to acute liver injury in patients, and its severity is associated with the severity of the disease. The objective of this study is to determine the incidence and factors affecting acute liver injury and its relationship with disease severity in COVID-19 patients treated in the cohort ward at Somdejphrajaotaksin Maharaj Hospital.
Materials and Methods: A cross-sectional study was conducted on moderate-to-severe COVID-19 patients who were hospitalized in the cohort ward. Demographic data, laboratory results, and clinical data were collected from April 1st to October 31st, 2021.
Results: Out of a total of 93 COVID-19 patients, the prevalence of acute liver injury (ALI) was 28% (95% CI 18.6-37.2). The factor associated with acute liver injury was male gender (p < 0.05). The average lymphocyte count in the group with acute liver injury was 1,154.77 cell/cumm., while in the group without acute liver injury, it was 1,530.02 cell/cumm. However, this difference was not statistically significant (p = 0.063). There was no significant difference in the use of vasopressors, ventilators, average hospital stay, and mortality between the two sample groups.
Conclusion: The study concluded that there was an incidence of acute liver injury in 28% of COVID-19 patients, and factors associated with the occurrence of acute liver injury in COVID-19 patients were male gender and a trend of lower lymphocyte count.
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