Nursing Care for Patients in the Step-Down Ward Following Hematopoietic Stem Cell Transplantation

Main Article Content

Wanpen Earphaopun

Abstract

Hematopoietic stem cell transplantation (HSCT) represents a final treatment option for various hematologic malignancies, with the primary goal being complete disease cure or achieving the longest possible remission period. Following HSCT, patients require close monitoring due to exposure to high-dose chemotherapy and immunosuppressive drugs. Hospitalization typically spans an average of 30 days, though this duration varies based on factors such as the patient's age, underlying disease, treatment specifics, source of stem cells, and potential complications. Based on medical statistics from Siriraj Hospital spanning 2013-2020, an average of 63 HSCT procedures are performed annually. Unfortunately, the limited number of available beds results in a waiting period of approximately 6-8 months, leading to longer queues for patients. This prolonged wait time is associated with a higher risk of disease relapse, increased cumulative toxicity from chemotherapy drugs, and a heightened mortality risk. In contrast, some foreign countries offer outpatient care for HSCT patients, which yields similar survival rates to inpatient care but at a lower cost, with increased patient satisfaction and improved quality of life. However, in Thailand and specifically at Siriraj Hospital, only inpatient care for HSCT patients is available due to various constraints, including the challenge of finding potential caregivers for 24-hour monitoring, transfer logistics, and bed availability for emergencies. To address these challenges, Siriraj Hospital has developed a continuous care program for post-HSCT patients within the recovery ward or step-down unit, aiming to reduce the length of stay at the bone marrow transplant unit and expedite HSCT procedures. This article focuses specifically on nursing care for patients after HSCT within the step-down ward, with the goal of equipping nurses with the knowledge and skills necessary to provide safe and effective care for post-HSCT patients.

Article Details

How to Cite
1.
Earphaopun W. Nursing Care for Patients in the Step-Down Ward Following Hematopoietic Stem Cell Transplantation. Siriraj Med Bull [Internet]. 2024 Jul. 1 [cited 2024 Dec. 27];17(3):224-30. Available from: https://he02.tci-thaijo.org/index.php/simedbull/article/view/267550
Section
Review Article

References

Khaddour K, Hana CK, Mewawalla P. Hematopoietic Stem Cell Transplantation. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536951/.

Silva TS, Horvath JDC, Pereira MP, David CNd, Vargas DF, Rigoni LDC, et al. Impact of waitlist time on post-HSCT survival: a cohort study at a hospital in southern Brazil. Hematology, Transfusion and Cell Therapy. 2023.

Gómez-Almaguer D, Gómez-De León A, Colunga-Pedraza PR, Cantú-Rodríguez OG, Gutierrez-Aguirre CH, Ruíz-Arguelles G. Outpatient allogeneic hematopoietic stem-cell transplantation: a review. Ther Adv Hematol. 2022;13:20406207221080739.

Owattanapanich W, Suphadirekkul K, Kunacheewa C, Ungprasert P, Prayongratana K. Risk of febrile neutropenia among patients with multiple myeloma or lymphoma who undergo inpatient versus outpatient autologous stem cell transplantation: a systematic review and meta-analysis. BMC Cancer. 2018;18(1):1126.

González MJ, Urizar E, Urtaran-Laresgoiti M, Nuño-Solinís R, Lázaro-Pérez E, Vázquez L, et al. Hospital and outpatient models for Hematopoietic Stem Cell Transplantation: A systematic review of comparative studies for health outcomes, experience of care and costs. PLoS One. 2021;16(8):e0254135.

Khalid Ahmed A-A, Abdulelah A. Outpatient Autologous Hematopoietic Stem Cell Transplantation in Patients with Multiple Myeloma. In: Khalid Ahmed A-A, editor. Recent Updates on Multiple Myeloma. Rijeka: IntechOpen; 2023. p. Ch. 9.

Memorial Sloan Kettering Cancer Center. Allogeneic Stem Cell Transplant:A Guide for Patients & Caregivers.2021 [cited 2024 Jan 19]. Available from: https://www.mskcc.org/cancer-care/patient-education/allogeneic-stem-cell-transplantation.

Memorial Sloan Kettering Cancer Center. Autologous Stem Cell Transplant:A Guide for Patients & Caregivers2021 [cited 2024 Jan 19]. Available from: https://www.mskcc.org/cancer-care/patient-education/autologous-stem-cell-transplant-guide-patients-caregivers.

Wallhult E, Kenyon M, Quinn B. Early and Acute Complications and the Principles of HSCT Nursing Care. In: Kenyon M, Babic A, editors. The European Blood and Marrow Transplantation Textbook for Nurses. 2 ed. Switzerland: Springer; 2023. p.185-216.

Nakagaki M, Kennedy GA, Gavin NC, Clavarino A, Whitfield K. The incidence of severe oral mucositis in patients undergoing different conditioning regimens in haematopoietic stem cell transplantation. Support Care Cancer. 2022;30(11):9141-9.

Sinsoongsud T. Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplantation: Literature Review and Nursing Implications. Nurs Res Inno J. 2023;29(1).

Murray J, Stringer J, Hutt D. Graft-Versus-Host Disease (GvHD). In: Kenyon M, Babic A, editors. EditionThe European Blood and Marrow Transplantation Textbook for Nurses. Switzerland: Springer; 2023.

Gooptu M, Antin JH. GVHD Prophylaxis 2020. Front Immunol. 2021;12:605726.

Malard F, Holler E, Sandmaier BM, Huang H, Mohty M. Acute graft-versus-host disease. Nat. Rev. Dis. Primers. 2023;9(1):27.

Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M, et al. Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant. 2016;51(7):906-12.

Özkan HA, Özkan SG. Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation in adult patients: Diagnosis, incidence, prophylaxis, and treatment. Transfusion and Apheresis Science. 2022;61(1):103372.

Bonifazi F, Barbato F, Ravaioli F, Sessa M, Defrancesco I, Arpinati M, et al. Diagnosis and Treatment of VOD/SOS After Allogeneic Hematopoietic Stem Cell Transplantation. Front Immunol. 2020;11:489.

Dalle J-H, Giralt SA. Hepatic Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation: Risk Factors and Stratification, Prophylaxis, and Treatment. Biology of Blood and Marrow Transplantation. 2016;22(3):400-9.

Mohty M, Malard F, Alaskar AS, Aljurf M, Arat M, Bader P, et al. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT). Bone Marrow Transplant. 2023;58(7):749-54.

วัจนา เนคมานุรักษ์, ลดาวัลย์ ฤทธิ์กล้า. การพัฒนาแนวปฏิบัติทางการพยาบาลในการป้องกันภาวะเม็ดเลือดขาวต่ำและมีไข้ (febrile neutropenia) ในผู้ป่วยที่ได้รับเคมีบำบัด. วารสารโรงพยาบาลธรรมศาสตร์เฉลิมพระเกียรติ. 2021;6(2):20-7.

Jamjumrus J, Chanpho D. Roles of Nurses in the Prevention and Management of the Febrile Neutropenia in Cancer Patients Undergoing Chemotherapy. Siriraj Med Bull. 2021;14(3):61-5.

Jarding EK, Flynn Makic MB. Central Line Care and Management: Adopting Evidence-Based Nursing Interventions. J Perianesth Nurs. 2021;36(4):328-33.

Nesher L, Chemaly RF, Shah DP, Mulanovich VE, Hosing C, Rolston KV. Utility of routine surveillance blood cultures in asymptomatic allogeneic hematopoietic stem cell transplant recipients with indwelling central venous catheters at a comprehensive cancer center. Am J Infect Control. 2014;42(10):1084-8.

Strasfeld L, Riches M. Infectious Complications. In: Maziarz RT, Slater SS, editors. Blood and Marrow Transplant Handbook. 3 ed. Switzerland: Springer; 2021. p.493-512.

Adkins BD, Booth GS, Vasu S. Transfusion support for stem cell transplant recipients. Seminars in Hematology. 2020;57(2):51-6.

Jekarl DW, Kim JK, Han JH, Lee H, Yoo J, Lim J, et al. Transfusion support in hematopoietic stem cell transplantation. Blood Res. 2023;58(S1):S1-s7.

Foukaneli T, Kerr P, Bolton-Maggs PHB, Cardigan R, Coles A, Gennery A, et al. Guidelines on the use of irradiated blood components. Br J Haemato. 2020;191(5):704-24.