The Role of Nurses in Caring for Adult and Elderly Critically Ill Patients with Dysglycemia
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Abstract
Dysglycemia is a common condition among critically ill patients admitted to intensive care units. It may manifest as either hyperglycemia or hypoglycemia, both of which have significant impacts on patient prognosis and survival. Maintaining blood glucose levels within an appropriate range is therefore a key element of effective critical care. The recommended target blood glucose range is 140–180 mg/dL, and intravenous insulin therapy should be initiated when glucose levels exceed 180 mg/dL. Tight glycemic control, defined as maintaining levels less than or equal to 110 mg/dL, is not recommended. Blood glucose monitoring should be performed every hour during the first 6–8 hours, then every 2 hours when levels remain stable for at least three consecutive measurements, and subsequently every 4 hours. Critical care nurses play a vital role in managing dysglycemia through ongoing assessment, close monitoring, collaboration with the multidisciplinary team, and prevention of complications related to inappropriate glucose levels. Therefore, it is essential for nurses to possess accurate knowledge and understanding of dysglycemia, including the importance of glycemic control, mechanisms of glucose regulation, contributing factors in critically ill patients, target glucose ranges, and appropriate nursing management. This knowledge ensures timely, accurate, and professional patient care. The purpose of this article is to present comprehensive knowledge regarding dysglycemia in critically ill adult and older adult patients. It aims to enhance nurses’ understanding of the pathophysiological mechanisms, underlying causes, and evidence-based nursing approaches that can be applied in patient care to promote safety, minimize complications, and reduce mortality in this vulnerable population.
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References
Joshi A, Mehta Y. Dysglycemia in ICU patients. J Card Crit Care. 2022;6:40–2. doi:10.1055/s-0042-1750116.
Honarmand K, Sirimaturos M, Hirshberg EL, Bircher NG, Agus MSD, Carpenter DL, et al. Society of Critical Care Medicine guidelines on glycemic control for critically ill children and adults 2024. Crit Care Med. 2024;52(4):e161–81.
Lacherade JC, Jacqueminet S, Preiser JC. An overview of hypoglycemia in the critically ill. J Diabetes Sci Technol. 2009;3(6):1242–9. doi:10.1177/193229680900300603.
Akirov A, Shochat T, Dotan I, Diker-Cohen T, Gorshtein A, Shimon I. Glycemic variability and mortality in patients hospitalized in general surgery wards. Surgery. 2019;166(2):184–92.
Khan SA, Shields S, Abusamaan MS, Mathioudakis N. Association between dysglycemia and the Charlson Comorbidity Index among hospitalized patients with diabetes. J Diabetes Complications. 2022;36(10):108305.
Okazaki T, Nabeshima T, Santanda T, Hoshina Y, Kondo Y, Yaegashi Y, et al. Association of relative dysglycemia with hospital mortality in critically ill patients: a retrospective study. Crit Care Med. 2024;52(9):1356–66.
Hantzidiamantis PJ, Awosika AO, Lappin SL. Physiology, glucose [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Apr 30 [cited 2025 Nov 11]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545201/
Olariu E, Pooley N, Danel A, Miret M, Preiser J-C. A systematic scoping review on the consequences of stress-related hyperglycemia. PLoS One 2018;13(04):e0194952.
Parvathareddy VP, Wu J, Thomas SS. Insulin resistance and insulin handling in chronic kidney disease. Compr Physiol. 2023;13(4):5069–76. doi:10.1002/cphy.c220019.
Akirov A, Grossman A, Shochat T, Shimon I. Mortality among hospitalized patients with hypoglycemia: insulin related and noninsulin related. J Clin Endocrinol Metab. 2017;102(2):416–424.
Mitsuyama Y, Shimizu K, Komukai S, Hirayama A, Takegawa R, Ebihara T, et al. Sepsis-associated hypoglycemia on admission is associated with increased mortality in intensive care unit patients. Acute Med Surg. 2022;9:e718.
Rivas AM, Nugent K. Hyperglycemia, insulin, and insulin in sepsis. Am J Med Sci. 2021 Mar;361(3):297–302.
AlEissa MS, AlGhofaili IA, Alotaibe HF, Yaslam MT, AlMujil MS, Arnous MM, et al. Incidence and risk factors associated with hypoglycemia among patients with chronic kidney disease: a systematic review. J Family Community Med. 2020;27(3):157–62.
American Diabetes Association. Standards of Care in Diabetes—2023 Abridged for Primary Care Providers. Clin Diabetes. 2023;41(1):4–31. doi:10.2337/cd23-as01.
Tanaka A, Yatabe T, Suhara T, Egi M. The optimal glycemic target in critically ill patients: an updated network meta-analysis. J Intensive Care. 2024;12:14.
Mehta Y, Mithal A, Kulkarni A, Reddy BR, Sharma J, Dixit S, et al. Practice guidelines for enteral nutrition management in dysglycemic critically ill patients: a relook for Indian scenario. Indian J Crit Care Med. 2019;23(12):594–603.
Rovida S, Bruni A, Pelaia C, Bosco V, Saraco G, Galluzzo E, et al. Nurse-led protocols for control of glycaemia in critically ill patients: a systematic review. Intensive Crit Care Nurs.2022;71:103247. doi:10.1016/j.iccn.2022.103247.
Elpasiony NMA, Hafez AA, Hendy A, Ibrahim RK, Kotp MH, Baghdadi NA, et al. Nurse-led insulin protocol efficacy for control of hyperglycemia in critically ill patients. BMC Nurs. 2025;24(1):924.
คณะกรรมการเภสัชกรรมและการบำบัด โรงพยาบาลศิริราช. คู่มือการใช้ยาที่มีความเสี่ยงสูง (High Alert Drug). ฉบับที่ 6. กรุงเทพฯ: โรงพยาบาลศิริราช; 2022. p.172–84.
Kitabchi AE, Umpierrez GE, Pasquel FJ, Wolfsdorf JI, Bhattarai M, Nyenwe EA, et al. Hyperglycemic crises in adults with diabetes: A consensus report. Diabetes Care. 2024;47(6):1257–1275.
American Diabetes Association. Glycemic goals and hypoglycemia: Standards of care in diabetes—2025. Diabetes Care. 2025;48(Suppl 1):S128–S145. doi:10.2337/dc25-S006.
American Diabetes Association Professional Practice Committee. Diabetes care in the hospital: Standards of care in diabetes—2025. Diabetes Care. 2025;48(Suppl 1):S321–34.