เปรียบเทียบประสิทธิผลความปลอดภัยและความพึงพอใจในการใช้ยาของตำรับยาทาพระเส้นกับไดโครฟิเนคเจลในการรักษาโรคข้อเข่าอักเสบ

Kanita Pheangsalud; Thavatchai  Kamoltham

Authors

Kanita Pheangsalud Suan Sunandha Rajabhat University
Thavatchai Kamoltham Suan Sunandha Rajabhat University

Keywords:

Ta-Pha-Sen, Diclofenac gel, Efficiency, Satisfaction, Safety, Osteoarthritis of Knees

Abstract

The current orthopedic disease is a major health problem as the incidence of the disease continues to increase, especially osteoarthritis. The problem of the disease should be treated properly to prevent health problems. This research study was a comparative efficiency, safety and satisfaction of Ta-Pha-Sen and Diclofenac Gel for treatment osteoarthritis of knees. The objective of this study was to 1) Compare efficiency, 2) Study safety and 3) Study the satisfaction of the drug use between the Ta-Pha-Sen and Diclofenac gel. Research methods: 75 volunteers were divided into 2 groups, with group 1 receiving Ta-Pha-Sen drug 2 ml. 3 times a day, 38 subjects and group 2 received Diclofenac gel 2 ml. 3 times a day, 37 subjects for 4 consecutive weeks, efficiency was assessed by VAS, WOMAC, knee circumference, satisfaction assessment and report adverse drug reaction (ADR). The research results were found that by using Ta-Pha-Sen and Diclofenac gel over a period of 4 weeks, both drugs were effective in reducing pain, stiffness, swelling and improved knee operability. When compared between Ta-Pha-Sen and Diclofenac gel, the trend of Ta-Pha-Sen was more effective at reducing pain, stiffness, and knee joint efficacy than Diclofenac gel statistically significant (p<.001) But, there was no statistically significant difference in reducing knee swelling (p<.05). Moreover, the Ta-Pha-Sen was more satisfied with the use of the drug than the Diclofenac gel. And in this study, No adverse drug reaction were found in Ta-Pha-Sen. Diclofenac gel were found adverse drug reaction. It is a mild symptom that can disappear on its own. Conclusion, Ta-Pha-Sen is another alternative as a guideline for drug selection and is safe for relieving the symptoms of Osteoarthritis of Knees.

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