Effect of Mulberry (Morus rubra) Juice on Blood Glucose and Satiety in Healthy Subjects
Keywords:
mulberry juice, blood glucose, satietyAbstract
Mulberry fruit contains anthocyanin which is an antioxidant in the flavonoid group, and it helps to regulate blood glucose and insulin levels in diabetic rats. The objective of this study was to determine the effects of a mulberry juice on blood glucose and satiety levels in healthy subjects compared to the control group. A cross-group study was conducted on 16 subjects, mean aged 21.00 ± 0.83 years and BMI 20.01 ± 1.28 kg/m2. All subjects were measured body composition, and then randomly selected to consume two research drinks which would be washed out for one week apart. The control drink was 180 ml of glucose and fructose solution, and the test drink was 180 ml mulberry juice. Subjects were measured their blood glucose levels, satiety scales, body temperature, blood pressure and heart rate at 0 minutes before drinking and after drinking at 30, 60, 90 and 120 minutes. The results showed that after drinking mulberry juice at 30 minutes, the blood glucose levels of mulberry juice group were significantly lower than the control group (p<0.05), while satiety levels, body temperature, and blood pressure were not statistically difference compared to the control group. In conclusion, mulberry juice may lower blood glucose levels after 30 minutes of drinking.
References
Aba, P. E., & Asuzu, I. U. (2018). Mechanisms of actions of some bioactive anti-diabetic principles from
phytochemicals of medicinal plants: A review. Indian Journal of Natural Products and
Resources (IJNPR)[Formerly Natural Product Radiance (NPR)], 9(2): 85-96.
Banu, S., Jabir, N. R., Manjunath, N. C., Khan, M. S., Ashraf, G. M., Kamal, M. A., & Tabrez, S. (2015).
Reduction of post-prandial hyperglycemia by mulberry tea in type-2 diabetes patients. Saudi
Journal of Biological Sciences, 22(1): 32-36.
Bao, T., Xu, Y., Gowd, V., Zhao, J., Xie, J., Liang, W., & Chen, W. (2016). Systematic study on
phytochemicals and antioxidant activity of some new and common mulberry cultivars in
China. Journal of Functional Foods, 25: 537-547.
Enkhmaa, B., Shiwaku, K., Katsube, T., Kitajima, K., Anuurad, E., Yamasaki, M., & Yamane, Y. (2005). Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate
atherosclerotic lesion development in LDL receptor-deficient mice. The Journal of nutrition,
(4): 729-734.
Gerasopoulos, D., & Stavroulakis, G. (1997). Quality characteristics of four mulberry (Morus sp) cultivars
in the area of Chania, Greece. Journal of the Science of Food and Agriculture, 73(2): 261-264.
Josic, J., Olsson, A. T., Wickeberg, J., Lindstedt, S., & Hlebowicz, J. (2010). Does green tea affect
postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial.
Nutrition Journal, 9(1): 1-8.
Kadam, R. A., Dhumal, N. D., & Khyade, V. B. (2019). The Mulberry, Morus alba (L.): The medicinal
herbal source for human health. Int. J. Curr. Microbiol. Appl. Sci, 8(4): 2941-2964.
Kim, I., & Lee, J. (2020). Variations in anthocyanin profiles and antioxidant activity of 12 genotypes of
mulberry (Morus spp.) fruits and their changes during processing. Antioxidants, 9(3): 242.
Lin, Y. C., Wu, C. J., Kuo, P. C., Chen, W. Y., & Tzen, J. T. (2020). Quercetin 3‐O‐malonylglucoside in the
leaves of mulberry (Morus alba) is a functional analog of ghrelin. Journal of Food Biochemistry,
(9): e13379.
Nakamura, K., & Nakamura, Y. (2018). Hunger and satiety signaling: modeling two
hypothalamomedullary pathways for energy homeostasis. Bioessays, 40(8): 1700252.
Park, S. W., Shin, K. C., Yoou, S.-K., Park, H. J., Eun, S. H., Bae, Y. M., . . . Choi, B. H. (2019). Effects of an
ethanolic extract of mulberry fruit on blood pressure and vascular remodeling in spontaneous
hypertensive rats. Clinical and Experimental Hypertension, 41(3): 280-286.
Rolls, E. (2007). Understanding the mechanisms of food intake and obesity. Obesity Reviews, 8: 67-72.
Sami, W., Ansari, T., Butt, N. S., & Ab Hamid, M. R. (2017). Effect of diet on type 2 diabetes mellitus: A
review. International journal of health sciences, 11(2): 65.
Solah, V. A., Meng, X., Wood, S., Gahler, R. J., Kerr, D. A., James, A. P., . . . Johnson, S. K. (2015). Effect of
training on the reliability of satiety evaluation and use of trained panellists to determine the
satiety effect of dietary fibre: A randomised controlled trial. PLoS One, 10(5): e0126202.
Stefanut, M. N., Cata, A., Pop, R., Tănasie, C., Boc, D., Ienaşcu, I., & Ordodi, V. (2013). Anti-hyperglycemic
effect of bilberry, blackberry and mulberry ultrasonic extracts on diabetic rats. Plant foods for
human nutrition, 68: 378-384.
Wang, Y., Xiang, L., Wang, C., Tang, C., & He, X. (2013). Antidiabetic and antioxidant effects and
phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract. PLoS One,
(7): e71144.
Wu, T., Tang, Q., Gao, Z., Yu, Z., Song, H., Zheng, X., & Chen, W. (2013). Blueberry and mulberry juice
prevent obesity development in C57BL/6 mice. PLoS One, 8(10): e77585.
Yan, F., Dai, G., & Zheng, X. (2016). Mulberry anthocyanin extract ameliorates insulin resistance by
regulating PI3K/AKT pathway in HepG2 cells and db/db mice. The Journal of Nutritional
Biochemistry, 36: 68-80.
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