The relationships between disease severity, impairments, functional abilities and personal factors in individuals with Parkinson’s disease

Main Article Content

Kanjana Niemrungruang
Pornpiroon Phuegsilp
Suweena Khacharoen
Jinjuta Suwannarat
Wunpen Chansirinukor
Sutang Tantanavivat

Abstract

Background: Parkinson’s disease affects function of body, functional capabilities, social participation and decreases quality of life. International Classification of Functioning Disability and Health (ICF)explains relationship among health conditions, body functions and structures, activities, participation environmental factors and personal factors. Therefore, for appropriate treatment planning for Parkinson's patients, therapists should conduct a comprehensive assessment taking into account all dimensions.


Objective: To evaluate the relationship between disease severity, impairments, functional abilities and personal factors in individuals with Parkinson’s disease (PD).


Methods: Twenty-six patients with PD were assessed 4 domains; 1.Disease severity: (Modified Hoehn and Yahr: Modified H&Y), 2. Impairments: Part III of Unified Parkinson’s Disease Rating Scale (UPDRS), 3. Functional abilities: Part II of UPDRS, balance (Berg Balance Scale: BBS), ambulation (Time Up and Go: TUG), gait speed (10-Metre Walk Test: 10mWT), and endurance (Six-Minute Walk Test: 6MWT),  and 4. Personal factors: gender, age and cognition (Thai Mental State Examination: TMSE). Researcher analyzed the correlation between aforementioned variables.


Results: The Modified H&Y was fair to moderate correlated with UPDRS II, UPDRS III and BBS (r=0.46 – 0.59). The TMSE was fair to moderate correlated with TUG, UPDRS III, age and BBS (r=0.36 – 0.56). And the BBS was fair to moderate correlated with all tests (r=0.47 – 0.74). But gender showed no correlation with other tests. 


Conclusion: There were relationships between disease severity, impairments, functional abilities and personal factors except for gender. Moreover, balance was correlated with all dimensions. The findings suggest that physical therapists should assess all aspects of patients, for holistic treatment.

Article Details

How to Cite
1.
Niemrungruang K, Phuegsilp P, Khacharoen S, Suwannarat J, Chansirinukor W, Tantanavivat S. The relationships between disease severity, impairments, functional abilities and personal factors in individuals with Parkinson’s disease. Thai J Phys Ther [internet]. 2023 Apr. 25 [cited 2026 Jan. 3];45(1):1-12. available from: https://he02.tci-thaijo.org/index.php/tjpt/article/view/256182
Section
Research Articles

References

Charoensuksiri K, Charoensuksiri S. A Health-related quality of life and activities of daily living of Thai elderly people in Pathumthani Social Welfare Development Center for Older Persons. J Assoc Med Sci. 2017; 50(3): 516-24. (in Thai)

Hartelt E, Scherbaum R, Kinkel M, Gold R, Muhlack S, Tönges L. Parkinson's Disease Multimodal Complex Treatment (PD-MCT): Analysis of Therapeutic Effects and Predictors for Improvement. J Clin Med. 2020; 9(6): 1874-89.

Keus SHJ, Munneke M, Graziano M, et al. European Physiotherapy Guideline for Parkinson’s disease. 1st ed. Netherlands: KNGF/ParkinsonNet, 2014: 21-2.

Muangpaisan W, Siritipakorn P, Assantachai P. Development of a Thai Parkinson’s disease screening tool and the prevalence of Parkinsonism and Parkinson’s disease, Based on a community survey in Bangkok. Neuroepidemiology. 2017; 49: 74-81.

Peachpunpisal C. Caregiver in Parkinson’s disease patient. JPNC. 2015; 26(1): 111-6. (in Thai)

Falvo MJ, Earhart GM. Six-minute walk distance in persons with Parkinson disease: a hierarchical regression model. Arch Phys Med Rehabil. 2009; 90(6): 1004-8.

Brusse KJ, Zimdars S, Zalewski KR, Steffen TM. Testing functional performance in people with Parkinson disease. Phys Ther. 2005; 85(2): 134-41.

Yang Y, Wang Y, Zhou Y, Chen C, Xing D, Wang C. Validity of the Functional Gait Assessment in patients with Parkinson disease: construct, concurrent, and predictive validity. Phys Ther. 2014; 94(3): 392-400.

Gian Pal, Joan O Keefe, Erin Robertson Dick, Bryan Bernard, Sharlet Anderson, Deborah Hall. Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson’s disease. J Neuroeng Rehabil. 2016; 13(94): 1-8.

Reekes TH, Higginson CI, Ledbetter CR, Sathivadivel N, Zweig RM, Disbrow EA. Sex specific cognitive differences in Parkinson disease. NPJ Parkinsons Dis. 2020; 6: 7.

Peachpunpisal C. Fall in Parkinson’s disease patient. JPNC. 2017; 28(2): 165-72. (in Thai)

Serrao M, Chini G, Caramanico G, Bartolo M, Castiglia SF, Ranavolo A, Conte C, Venditto T, Coppola G, di Lorenzo C, Cardinali P, Pierelli F. Prediction of Responsiveness of Gait Variables to Rehabilitation Training in Parkinson's Disease. Front Neurol. 2019; 10: 826.

Rittichuai R, Jitmanas A, Ruksachol O, Intarapak W, Khongnual N, Tunyarak H. Factors associated with dementia among the elderly in Nakhon Si Thammarat. JSCT. 2020; 13(1): 56-64. (in Thai)

Kanjananopinit S, Charoensak S, Keawpornsawan T. The study of Psychometric properties of cognistat Thai version. J Psychiatr Assoc Thailand. 2014; 59(4): 409-18. (in Thai)

Muangpaisan W, Assantachi P, Sitthichai K, Richarason K, Brayne C. The distribution of Thai Mental State Examination Scores among Non-Demented elderly in Suburban Bangkok Metropolitan and associated factors. J Med Assoc Thai. 2015; 98(9): 916-24.

Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins GT, Counsell C, Giladi N, Holloway RG, Moore CG, Wenning GK, Yahr MD, Seidl L; Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord. 2004; 19(9): 1020-8.

Steffen T, Seney M. Test-retest reliability and minimal detectable change on balance and ambulation tests, the 36-item short-form health survey, and the unified Parkinson disease rating scale in people with parkinsonism. Phys Ther. 2008; 88(6): 733-46.

Landers MR, Backlund A, Davenport J, Fortune J, Schuerman S, Altenburger P. Postural instability in idiopathic Parkinson's disease: discriminating fallers from nonfallers based on standardized clinical measures. J Neurol Phys Ther. 2008; 32(2): 56-61.

Vance RC, Healy DG, Galvin R, French HP. Dual tasking with the timed "up & go" test improves detection of risk of falls in people with Parkinson disease. Phys Ther. 2015; 95(1): 95-102.

Lindholm B, Nilsson MH, Hansson O, Hagell P. The clinical significance of 10-m walk test standardizations in Parkinson's disease. J Neurol. 2018; 265(8): 1829-35.

Cataneo DC, Kobayasi S, Carvalho LR, Paccanaro RC, Cataneo AJ. Accuracy of six minute walk test, stair test and spirometry using maximal oxygen uptake as gold standard. Acta Cir Bras. 2010; 25(2): 194-200.

Hamani C, Lozano AM. Physiology and pathophysiology of Parkinson's disease. Ann N Y Acad Sci. 2003; 991: 15-21.

Kim SM, Kim DH, Yang Y, Ha SW, Han JH. Gait Patterns in Parkinson's Disease with or without Cognitive Impairment. Dement Neurocogn Disord. 2018; 17(2): 57-65.

Haaxma CA, Bloem BR, Borm GF, Oyen WJ, Leenders KL, Eshuis S, Booij J, Dluzen DE, Horstink MW. Gender differences in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2007; 78(8): 819-24.

Factor SA, Steenland NK, Higgins DS, Molho ES, Kay DM, Montimurro J, Rosen AR, Zabetian CP, Payami H. Postural instability/gait disturbance in Parkinson's disease has distinct subtypes: an exploratory analysis. J Neurol Neurosurg Psychiatry. 2011; 82(5): 564-8.

Shady NAA, Mansour AH, Khalefa AIM, Salem EY. Effect of endurance training on balance in Parkinson’s Patients. Med J Cairo Univ. 2020; 88(1): 31-38.