Detection of Carbapenem-Resistant Enterobacteriaceae among Patients Admitted in Maharaj Nakhon Si Thammarat Hospital
Keywords:
CarbapenemaseAbstract
This retrospective study aimed to describe how the antibiotic resistance crisis a public health threat worldwide, that can be attributed to the overuse and misuse of these medications. Study is a retrospective about the increasing Carbapenem-Resistant Enterobacteriaceae (CRE) infections, which are very difficult to treat. Participants were selected from the in-patient department of Maharaj Nakhon Si Thammarat Hospital. Data were collected during the period from 2013-2018. Data were analyzed by using screening CRE with disc diffusion, and carbapenemase enzyme with multiplex PCR from the enterobacteriaceae family 17. As a result, 459 isolates showed that CRE was 215 isolated or 1.2 %. The prevalence of CRE from 2013-2018 showed that infections continued to increase by 0.5, 0.5, 0.6 1.0, 2.6, 2.1 respectively. This study revealed CRE in K. pneumoniae, E. coli, and E. cloacae with 52.6, 31.2, and 15.3 %, respectively. The test results for Carbapenem resistance genes from CREs found were mostly blaNDM genes, with 77% from K. pneumoniae, followed by 15% of blaNDM genes mixed with blaOXA48-like genes. The rest genes were blaOXA48-like, blaIPM gene, and other genes (2%, 15%, and 5%, respectively). Thus, per findings, doctors can use as a guideline for rational use of antibiotics, and plan for treatment of CRE patients in order to reduce drug resistance in the population.
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