Actinic granuloma: A case report

Authors

  • Piyaroj Sethabutra DEPARTMENT OF DERMATOLOGY, FACULTY OF MEDICINE, SIRIRAJ HOSPITAL. BANGKOK, THAILAND
  • Sumanas Bunyaratavej DEPARTMENT OF DERMATOLOGY, FACULTY OF MEDICINE, SIRIRAJ HOSPITAL. BANGKOK, THAILAND
  • Penvadee Pattanaprichakul DEPARTMENT OF DERMATOLOGY, FACULTY OF MEDICINE, SIRIRAJ HOSPITAL. BANGKOK, THAILAND

Keywords:

Actinic granuloma, Annular elastolytic giant cell granuloma, Elastophagocytosis

Abstract

Actinic granuloma is an uncommon non-infectious granulomatous skin disease, which pathogenesis is still unclear. Diagnosis is made by a histopathology of granulomatous inflammation with distinct elastophagocytosis. Response to treatment is not appreciable.

We report a 51-year-old woman presenting with multiple asymptomatic slow growing annular erythematous plagues aggravated by sunexposure. Histopathology revealed diffuse granulomatous reaction with engulfment of elastic, elastophagocytosis. She was treated with oral acitretin with moderate response but the medication was discontinue due to transaminitis.

References

Wee JS, Moosa Y, Misch K, Chong H, Natkunarajah J. Actinic granuloma: a history of photoexacerbation and the importance of a radial 'three-zone' biopsy. Clin Exp Dermatol ;38: 219-21.

Hanke CW, Bailin PL, Roenigk HH, Jr. Annular elastolytic giant cell granuloma. A clinicopathologic study of five cases and a review of similar entities. J Am Acad Dermatol 1979; 1: 413-21.

Fujimoto N, Akagi A, Tajima S. Expression of 67-kDa elastin receptor in annular elastolytic giant cell granuloma: elastin peptides induce monocyte-derived dendritic cells or macrophages to form granuloma in vitro. Exp Dermatol 2004; 13:179-84.

McGrae JD, Jr. Actinic granuloma. A clinical, histopathologic, and immunocytochemical study. Arch Dermatol 1986; 122: 43-7.

Vehring KH, Bonsmann G, Brocker EB, Hamm H. [Annular elastolytic giant cell granuloma--differential diagnosis of cutaneous granulomatosis]. Hautarzt 1991; 42: 391-5.

Al-Hoqail IA, Al-Ghamdi AM, Martinka M, Crawford RI. Actinic granuloma is a unique and distinct entity: a comparative study with granuloma annulare. Am J Dermatopathol 2002; 24: 209-12.

Ragaz A, Ackerman AB. Is actinic granuloma a specific condition? Am J Dermatopathol 1979; 1: 43-50.

Steffen C. Actinic granuloma (O'Brien). J Cutan Pathol 1988; 15: 66-74.

Revenga F, Rovira I, Pimentel J, Alejo M. Annular elastolytic giant cell granuloma--actinic granuloma? Clin Exp Dermatol 1996; 21: 51-3.

Ozkaya-Bayazit E, Buyukbabani N, Baykal C, Ozturk A, Okcu M, Soyer HP. Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine. Br J Dermatol 1999; 140: 525-30.

Ratnavel RC, Grant JW, Handfield-Jones SE, Norris PG. O'Brien's actinic granuloma: response to isotretinoin. J R Soc Med. 1995;88:528P-9P.

Stefanaki C, Panagiotopoulos A, Kostakis P, Stefanaki K, Petridis A. Actinic granuloma successfully treated with acitretin. Int J Dermatol. 2005;44:163-6.

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Published

2026-06-09

How to Cite

Sethabutra, P., Bunyaratavej, S., & Pattanaprichakul, P. (2026). Actinic granuloma: A case report. Thai Journal of Dermatology, 29(3), 189–193. retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/282860

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Section

Case Report