Toxicity of Methotrexate

Authors

  • Thanakorn Sirisamut Pharmacy Department, Siriraj Hospital

Keywords:

methotrexate, antineoplastic agents, medication error, leucovorin, bone marrow suppression

Abstract

Methotrexate is an antimetabolite agent with various indications either cancer or non-cancer. It is administered by many routes such as oral, mostly intake once a week while other drugs are generally taken every day, and parenteral, including intravenous, subcutaneous, and intramuscular. These various routes of administration increase risk of medication error and may lead to drug toxicity. Methotrexate possesses complex pharmacological property and its intoxication signs and symptoms are not specific. Misdiagnose may occur in case of improper or non-comprehensive patient interview and investigation. However, there are various practice to solve the intoxication of methotrexate such as leucovorin administration, high-flux hemodialysis, or leukocyte stimulating agent administration. These practices increase survival of intoxicated patients.

Author Biography

Thanakorn Sirisamut, Pharmacy Department, Siriraj Hospital

B.Pharm, M.Sc. (Pharmacol)

References

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Published

2022-08-31

How to Cite

1.
Sirisamut T. Toxicity of Methotrexate. Thai J Hosp Pharm [Internet]. 2022 Aug. 31 [cited 2024 Sep. 19];32(2):126-32. Available from: https://he02.tci-thaijo.org/index.php/TJHP/article/view/254773