Factors Predicting Quality of Life of Hepatocellular Carcinoma Patients Undergoing Transarterial Chemoembolisation

  • อรุณ นิลเลิศ หอผู้ป่วยผะอบฯ5(พิเศษรวม) โรงพยาบาลศิริราช เลขที่ 2 ถนนวังหลัง แขวงศิริราช เขตบางกอกน้อย กรุงเทพมหานคร
  • ผ่องศรี ศรีมรกต
  • เกศศิริ วงษ์คงคำ
  • สมราช ธรรมธรวัฒน์
Keywords: fatigue, anorexia, insomnia, quality of life, patients with hepatocellular carcinoma, transarterial chemoembolisation


     Objective: To study predictive correlations between fatigue, insomnia and anorexia,and the quality of life of hepatocellular carcinoma (HCC) patients during four to eight weeks after undergoing transarterial chemoembolisation (TACE).
     Design: Predictive correlational research.
     Methodology: The subjects were 77 HCC patients receiving monitoring check-ups in an out-patient ward during 4 to 8 weeks after undergoing transarterial chemoembolisation. Data were collected through a set of questionnaires: 1) a general information questionnaire; 2) the Fatigue Symptom Inventory; 3) the Insomnia Severity Index; 4) the Council on Nutrition Appetite Questionnaire; and 5) the Functional Assessment of Cancer Therapy-Hepatobiliary. The data were analysed using descriptive statistics and stepwise multiple regression analysis.
      Results: Based on the results, the participants displayed mild fatigue ( = 19.31,SD = 27.09), no insomnia ( = 6.39, SD = 7.74), moderate anorexia ( = 17.25, SD = 5.55)and good quality of life ( = 138.36, SD = 22.99). The most influential factor affecting the quality of life was fatigue (ß = -.49, p < .001), followed by anorexia (ß = -.38,p < .001) and insomnia (ß = -.18, p < .001). These three factors were capable of predicting the patients’ quality of life by up to 80% (R2 = .80, F = 96.03, p < .001).
     Recommendations: Thorough evaluation of the severity of fatigue, anorexia and insomnia in hepatocellular carcinoma patients after TACE treatment is instrumental in successfully controlling or alleviating their symptoms, or preventing such symptoms from escalating and affecting the patients’ quality of life.


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How to Cite
นิลเลิศอ, ศรีมรกตผ, วงษ์คงคำเ, ธรรมธรวัฒน์ส. Factors Predicting Quality of Life of Hepatocellular Carcinoma Patients Undergoing Transarterial Chemoembolisation. TJNC [Internet]. 2019Apr.23 [cited 2020Sep.27];34(2):127-40. Available from: https://he02.tci-thaijo.org/index.php/TJONC/article/view/160724