Factors Predicting Postoperative Recuperation in Patients Having Undergone Hepatectomy

Authors

  • Tanyalak Cheewaprapai Faculty of Nursing, Mahidol University.
  • Kessiri Wongkongkam Faculty of Nursing, Mahidol University
  • Suporn Danaidutsadeekul Faculty of Nursing, Mahidol University
  • Pongserath Sirichindakyl Department of Surgery, Chulalongkorn University

Keywords:

perioperative blood loss, nutritional status, comorbidity, state anxiety, recuperation, hepatectomy

Abstract

Objective: To study the predictive power of perioperative blood loss, preoperative nutritional status, comorbidity, and state anxiety on hepatectomy patients’ postoperative recuperation 

Design: Descriptive predictive study design 

Methodology: The subjects were 126 patients having received open abdominal hepatectomy surgery at two tertiary hospitals. The research framework employed was based on Roy’s theory of adaptation. Data were gathered from the patients’ medical records and topical interviews according to the data-gathering instruments, namely, the Modified Nutrition Alert Form, Charlson’s Comorbidity Index, State Anxiety Inventory Y-1, and Quality of Postoperative Recovery-40. The data were analysed using descriptive statistics and multiple regression analysis with enter method, with significance level set at .05. 

Results: The subjects’ highest score was in the category of postoperative, pre-discharge recuperation (X = 177.56, SD = 16.301). The subjects had low perioperative blood loss ( X = 635.95, SD = 803.960), moderate preoperative malnutrition (X = 7.41, SD = 3.176), high preoperative comorbidity (X = 4.63, SD = 3.019), and moderate state anxiety (X = 51.34, SD = 7.094). A predictive power analysis showed that perioperative blood loss, preoperative nutritional status, preoperative comorbidity, and state anxiety could jointly predict 11% (R2 = 0.110, F (df1, df2) = 3.724 (4, 121), p = 0.007) postoperative recovery in patients who had undergone hepatectomy. Perioperative blood loss and state anxiety were identified as having significant influence on the prediction of postoperative patients’ recuperation, at (β = -0.247, β = -0.179, p < 0.05), respectively.

Recommendations : Perioperative blood loss and state anxiety could jointly predict hepatectomy patients’ postoperative recovery. Nurses should, therefore, be aware of the importance of assessing perioperative blood loss and focus on preparing a surgical method that effectively minimises perioperative blood loss, maintains postoperative water balance, and regulates postoperative state anxiety, in order to enhance the patients’ postoperative recovery. 

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References

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49.

Ministry of Public Health. Public Health Statistics A.D. 2020 [Internet]. Nonthaburi: Strategy and Planning Division; 2021 [cited 2022 May 20].Available from: https://bps.moph.go.th.

National Cancer Institute. Hospital based cancer registry 2020 [Internet]. Bangkok: Medical Record and Databased Cancer Unit,Medical Digital Division; 2021 [cited 2022 May 20]. Available from: https://www.nci.go.th.

Koh YX, Tan HJ, Liew YX, Syn N, Teo JY, Lee SY, et al. Liver resection for nonalcoholic fatty liver disease-associated hepatocellular carcinoma. J Am Coll Surg. 2019;229(5):467-78.

Thai Association for the Study of the liver. Hepatocellular carcinoma. Nonthaburi: Parbpim; 2015. (in Thai)

McNally SJ, Revie EJ, Massie LJ, McKeown DW, Parks RW, Garden OJ, et al. Factors in perioperative care that determine blood loss in liver surgery. HPB (Oxford). 2012;14(4):236-41.

Dieu A, Huynen P, Lavand, homme P, Beloeil H, Freys SM, et al. Pain management after open liver resection: Procedure specific postoperative pain management (PROSPECT) recommendations. Reg Anesth Pain Med. 2021;46(5):433-45.

Allvin R, Berg K, Idvall E, Nilsson U. Postoperative recovery: a concept analysis. J Adv Nurs. 2007; 57(5):552-8.

Marasco G, Serenari M, Renzulli M, Alemanni LV, Rossini B, Pettinari I, et al. Clinical impact of sarcopenia assessment in patients with hepatocellular carcinoma undergoing treatments. J Gastroenterol. 2020; 55(10):927-

Micó-Carnero M, Rojano-Alfonso C, Álvarez-Mercado AI, Gracia-Sancho J, Casillas-Ramírez A, Peralta C. Effects of gut metabolites and microbiota in healthy and marginal livers submitted to surgery. Int J Mol Sci. 2020;22(1):1-28.

Takahashi K, Kurokawa T, Oshiro Y, Fukunaga K, Sakashita S, Ohkohchi N. Postoperative decrease in platelet counts is associated with delayed liver function recovery and complications after partial hepatectomy. Tohoku J Exp Med. 2016;239(1):47-55.

Coelho FF, Kruger JAP, Fonseca GM, Araújo RLC, Jeismann VB, Perini MV, et al. Laparoscopic liver resection: Experience based guidelines. World J Gastrointest Surg. 2016;8(1):5-26.

Tzeng C-WD, Cooper AB, Vauthey J-N, Curley SA, Aloia TA. Predictors of morbidity and mortality after hepatectomy in elderly patients: analysis of 7621 NSQIP patients. HPB (Oxford). 2014;16(5):459-68.

Tran TB, Worhunsky DJ, Spain DA, Dua MM, Visser BC, Norton JA, et al. The significance of underlying cardiac comorbidity on major adverse cardiac events after major liver resection. HPB (Oxford). 2016; 18(9):742-7.

Khan FA, Nazir S. Assessment of pre operative anxiety in patients for elective surgery. J Anaesthesiol Clin Pharmacol. 2007;23(3):259-62.

Ip HY, Abrishami A, Peng PW, Wong J, Chung F. Predictors of postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology. 2009; 111(3):657-77.

Roy SC. The Roy adaptation model. 3nd ed. Upper Saddle River: NJ; 2009.

Borson S, Scanlan JM, Chen P, Ganguli M. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003; 51(10):1451-4.

Polit DF, Beck CT. Using inferential statistics to test hypothses, New York: Lippinott Williams & Wilkin; 2012.

Spahn DR, Cerny V, Coats TJ, Duranteau J, FernándezMondéjar E, Gordini G, et al. Management of bleeding following major trauma: a European guideline. Crit Care. 2007;11(1):1-74.

Research Center for Nutritional Support. Modified Nutrition Alert Form [Internet]. 2016 [cited 2022 May 20]. Available from https://www.si.mahidol. ac.th/Th/division/nursing/NDivision/N_qd/admin/ download_file s/173_72_1.pdf

Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. J Clin Epidemiol. 2008; 61(12):1234-40.

Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Mannual for The State-Trait Anxiety Iventory (STAI) Form Y: Self-evaluation questionnaire. California: Consulting Psychologists Press; 1983.

Chanwatana B, Jintanadilok N, Apanakapan P, Chalamket W, Melnyk BM. Effect of information intervention on mothers’ anxiety level during their children’s hospitalization. Thai J Pediatr. 2001;1(2):26-36. (in Thai)

Klaewklong S, Chanruangvanich W, Danaidutsadeekul S, Riansuwan K. Relation of Comorbidity, Grip Strength and Stress to Hip Fracture Patients’ Post-Operative Function Recovery. TJONC. 2014;29(2):36-48. (in Thai)

Myles PS, Weitkamp B, Jones K, Melick J, Hensen S. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth. 2000; 84(1):11-5.

Damri S, Toskulkao T, Kimpee S, Chanruangvanich W. Effects of a recovery promoting program on selfefficacy and the quality of recovery among patients with emergency abdominal surgery. NRCT [internet]. 2010 [cited 2022 May 20]. Available from: https:// doi.nrct.go.th/ListDoi/listDetail?Resolve/doi= 10.14457/MU.

Field AP, Miles J, Field, Z. Discovering statistics using R, Andy Field, Jeremy Miles, Zoe Field. London: Thousand Oaks; 2012.

Nishikawa H, Kimura T, Kita R, Osaki Y. Treatment for hepatocellular carcinoma in elderly patients: a literature review. J Cancer. 2013;4(8):635-43.

Marrero JA, Fontana RJ, Fu S, Conjeevaram HS, Su GL, Lok AS. Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma. J Hepatol. 2005;42(2):218-24.

Sugawara K, Kawaguchi Y, Nomura Y, Suka Y, Kawasaki K, Uemura Y, et al. Perioperative factors predicting prolonged postoperative ileus after major abdominal surgery. J Gastrointest Surg. 2018;22(3):508-15.

Brown EN, Pavone KJ, Naranjo M. Multimodal general anesthesia: theory and practice. Anesth Analg. 2018; 127(5):1246-58.

Wong-Lun-Hing EM, van Dam RM, Welsh FKS, Wells JKG, John TG, Cresswell AB, et al. Postoperative pain control using continuous i.m. bupivacaine infusion plus patient-controlled analgesia compared with epidural analgesia after major hepatectomy. HPB. 2014; 16(7):601-9.

Noda T, Eguchi H, Wada H, Iwagami Y, Yamada D, Asaoka T, et al. Short-term surgical outcomes of minimally invasive repeat hepatectomy for recurrent liver cancer. Surg Endosc. 2018;32(1):46-52 .

Gumus K. The effects of preoperative and postoperative anxiety on the quality of recovery in patients undergoing abdominal surgery. J Perianesth Nur. 2021;36(2): 174-8.

Mushlin PS, Gelman S. Hepatic physiology and pathophysiology. 7th ed. Philadelphia: Churchill Livingstone Elsevier; 2010.

Newman CB, Preiss D, Tobert JA, Jacobson TA, Page RL, 2nd, Goldstein LB, et al. Statin safety and associated adverse events: a scientific statement from the American Heart Association. Arterioscler Thromb Vasc Biol. 2019;39(2):e38-e81.

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Published

2022-08-07

How to Cite

1.
Cheewaprapai T, Wongkongkam K, Danaidutsadeekul S, Sirichindakyl P. Factors Predicting Postoperative Recuperation in Patients Having Undergone Hepatectomy . J Thai Nurse midwife Counc [Internet]. 2022 Aug. 7 [cited 2024 Dec. 22];37(03):109-27. Available from: https://he02.tci-thaijo.org/index.php/TJONC/article/view/255608

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Research Articles