Factors Influencing Adherence to Treatment in Adult Patients with Hypertension

Authors

  • Petlada Chansri Program in Adult and Gerontological Nursing, Faculty of Nursing, Mahidol University, Bangkok, Thailand
  • Autchariya Poungkaew Department of Medical Nursing, Faculty of Nursing, Mahidol University, Bangkok, Thailand
  • Aurawamon Sriyuktasuth Department of Medical Nursing, Faculty of Nursing, Mahidol University, Bangkok, Thailand
  • Srisakul Chirakarnjanakorn Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

DOI:

https://doi.org/10.60099/jtnmc.v39i02.268032

Keywords:

cardiovascular disease, adult patients with hypertension, adherence to treatment, perceived severity and risk, work status, quality of care

Abstract

Introduction Adherence to treatment including medication and lifestyle modification is crucial for improving health outcomes in patients with hypertension. However, there is limited research investigating the factors influencing adherence to medication and lifestyle modification, particularly among adult patients diagnosed with hypertension. 

Objective To investigate adherence to treatment and the predictive power of work status, comorbidity, complexity of medication regimens, perceived severity and risk of hypertension complications, and quality of care affecting adherence to treatment in adult patients with hypertension. 

Design Cross-sectional correlational predictive research using the multidimensional adherence model as the conceptual framework.

Methodology The sample included 156 adult patients with essential hypertension aged 18 to 59 years old who had received antihypertensive medication and lifestyle modification treatment for at least six months at a super-tertiary hospital’s hypertension clinic. Data were collected between April and July 2023. The research instruments consisted of a general profile questionnaire, a treatment adherence questionnaire for patients with hypertension, a perceived severity and risk of hypertension complications questionnaire, a patient assessment of chronic illness care, the Charlson Comorbidity Index, a medication regimen complexity index, and an illness record form. These instruments were examined for content validity by experts and tested for reliability prior to use in data collection. The reliability ranged from .77-1.00. The data were analyzed using descriptive statistics and multiple linear regression. 

Results The sample had an average age of 46.50 years (SD = 9.65); 63.46% were female. The average score for adherence to treatment was 87.97 (SD = 9.02), with the highest score for average medication adherence of 34.37 (SD = 2.52) and the lowest score for average exercise adherence of 4.33 (SD = 1.89). Additionally, 14.74% were overweight, and 71.80% were obese. The majority were employed (83.33%), without any comorbidities (62.82%), and had a low level of medication regimen complexity (68.59%). Furthermore, they demonstrated a high level of perceived severity and risk of hypertension complications (96.15%) and reported a high level of quality of care (61.54%). In the Multiple linear regression, 30.9% of the variance in adherence to treatment was explained (Adjusted R2 = .309 F(5,150) = 14.858, p < .001). Work status (β = -.262, p < .001), comorbidity (β = -.184, p = .020), perceived severity and risk of hypertension complications (β = .466, p < .001), and quality of care (β = .165, p = .017) together were significant predictors of adherence to treatment in adult patients with hypertension. 

Recommendation To promote adherence to treatment in adult patients with hypertension, nurses should develop strategy to improve quality of care within hypertension clinics and enhance the perceived severity and risk of hypertension complications as well as enhance lifestyle modifications particularly regarding diet and exercise for overweight and obese adults with hypertension.

Downloads

Download data is not yet available.

References

Zhou B, Carrillo-Larco RM, Danaei G, Riley LM, Paciorek CJ, Stevens GA, et al. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398:957-80. https://doi.org/10.1016/s0140-6736(21)01330-1 PMID: 34450083

Aekplakorn W, Puckcharern H, Satheannoppakao W. An evaluation of the national health examination survey in Thailand 6th 2019-2020. Bangkok: Aksorn Graphic and Design Publishing; 2021. Available from: https://www.hiso.or.th/hiso/picture/reportHealth/report/sreport6/sreport6_full.pdf (in Thai)

Thai Hypertension Society. 2019 Thai Guidelines on The Treatment of Hypertension. Chiang Mai: Trick Think; 2019. Available from: https://www.thaihypertension.org/hypertensiondetail.php?n_ id=442 (in Thai)

Burnier M, Egan BM. Adherence in hypertension: a review of prevalence, risk factors, impact, and management. Circ Res. 2019;124(7):1124-40. https://doi.org/10.1161/circresaha.118.313220 PMID: 30920917

Whelton PK, Carey RM, Aronow WS, Casey DE, Jr., Collins KJ, Dennison Himmelfarb C, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: a Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):e13-e115. https://doi.org/10.1161/hyp.0000000000000065 PMID: 29133356

World Health Organization. Adherence to long-term therapies: evidence for action. [Internet]. 2003 [cited 2022Aug25]. Available from: https://iris.who.int/bitstream/handle/10665/42682/9241545992.pdf;jsessionid=DCA2825725FD40BBDB8BA5E0FB8D3F98?sequence=1

Lee H, Yano Y, Cho SMJ, Heo JE, Kim DW, Park S, et al. Adherence to antihypertensive medication and incident cardiovascular events in young adults with hypertension. Hypertension. 2021;77(4):1341-9. https://doi.org/10.1161/hypertensionaha.120.16784 PMID: 33641364

Spikes T, Higgins M, Lewis T, Dunbar S. B. The associations among illness perceptions, resilient coping, and medication adherence in young adult hypertensive black women. J Clin Hypertens. 2019;21(11):1695-1704. https://doi.org/10.1111/jch.13712 PMID: 31556484

Meekusol S, Maneesriwongul W, Orathai P, Pongthavornkamol K, Sharps PW. Factors predicting women’s adherence to hypertensive treatment. PRIJNR. 2020 Aug 15;25(1):131-42. Available from: https://he02.tci-thaijo.org/index.php/PRIJNR/article/view/241920/168398

Dorji N, Samartkit N, Masingboon K. Factors influencing lifestyle modification among persons with hypertension in Punakha, Bhutan. BKKMEDJ. 2021;17(1):1-8. Available from: https://he02.tci-thaijo.org/index.php/bkkmedj/article/view/245755/169602

Andualem A, Liknaw T, Edmealem A, Gedefaw M. Adherence to antihypertensive medications among adult hypertensive patients attending chronic follow-up units of Dessie Referral Hospital, Northeastern Ethiopia: a cross-sectional study. Medicine (Baltimore). 2021; 100(31):1-6. https://doi.org/10.1097/md.0000000000026818 PMID: 34397841

Hussein A, Awad MS, Mahmoud HEM. Patient adherence to antihypertensive medications in upper Egypt: a cross-sectional study. Egypt Heart J. 2020;72(1):29. https://doi.org/10.1186/s43044-020-00066-0 PMID: 32451726

Yazie TS, Mengistu WE, Asmare Z, Belete AM, Teshome AA, Yimer YS. Medication regimen complexity and its association with adherence and blood pressure control among hypertensive patients at selected hospitals of South Gondar Zone: a hospital based cross sectional study. PLoS One. 2022;17(8): e02727 17. https://doi.org/10.1371/journal.pone.0272717 PMID: 35980967

Tanukaew D, Watanakijkrilert D, Sriyuktasuth A, Chattranukulchai P. Factors predicting medication adherence in patients with essential hypertension. Thai Red Cross Nursing Journal. 2022;15(1):127-43. Available from: https://he02.tci-thaijo.org/index.php/trcnj/article/view/247347/176346 (in Thai)

Shiraly R, Khani Jeihooni A, Bakhshizadeh Shirazi R. Perception of risk of hypertension related complications and adherence to antihypertensive drugs: a primary healthcare based cross-sectional study. BMC Prim Care. 2022;23(1):303. https://doi.org/10.1186/s12875-022-01918-1 PMID: 36443657

Namwong A. Relationships between selected factors and adherence to therapeutic regimens among older adults with hypertension. Journal of Nursing and Education. 2015;8(4):78-93. Available from: https://he01.tci-thaijo.org/index.php/JNAE/article/view/48009 (in Thai)

Teh XR, Lim MT, Tong SF, Husin M, Khamis N, Sivasampu S. Quality of hypertension management in public primary care clinics in Malaysia: an update. PLoS One. 2020;15(8):e0237083. https://doi.org/10.1371/journal.pone.0237083 PMID: 32780769

Fortuna RJ, Nagel AK, Rocco TA, Legette-Sobers S, Quigley DD. Patient experience with care and its association with adherence to hypertension medications. Am J Hypertens. 2018;31(3):340-5. https://doi.org/10.1093/ajh/hpx200 PMID: 29253071

Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009; 41(4):1149-60. https://doi.org/10.3758/brm.41.4.1149 PMID: 19897823

Ismael D, Qadir C. Factors affecting treatment compliance of hypertensive patients in Erbil city. Kufa J Nurs Sci. 2015;5(2):1-8. https://doi.org/10.36321/kjns.vi20152.2601

Ma C, Chen S, You L, Luo Z, Xing C. Development and psychometric evaluation of the Treatment Adherence Questionnaire for Patients with Hypertension. J Adv Nurs. 2021;68(6):1402-13. https://doi.org/10.1111/j.1365-2648.2011.05835.x PMID: 21954893

Samdaengsarn D, Chinnawong T, Thaniwatthananon P. Factors related to treatment adherence in older persons with hypertension. Songklanagarind Journal of Nursing. 2019;39(3):51-66. Available from: https://he02.tci-thaijo.org/index.php/nur-psu/article/view/218933/152718 (in Thai)

Glasgow RE, Wagner EH, Schaefer J, Mahoney LD, Reid RJ, Greene SM. Development and validation of the Patient Assessment of Chronic Illness Care (PACIC). Med Care. 2005; 43(5):436-44. https://doi.org/10.1097/01.mlr.0000160375.47920.8c PMID: 15838407

Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. J Clin Epidemiol. 2008;61(12): 1234-40. https://doi.org/10.1016/j.jclinepi.2008.01.006 PMID: 18619805

George J, Phun Y, Bailey MJ, Kong DC, Stewart K. Development and validation of the medication regimen complexity index. Ann Pharmacother. 2004;38(9):1369-76. https://doi.org/10.1345/aph.1d479 PMID: 15266038

Hu L, Ding H, Hu G, Wang Z, Liu S, Liu Y. How perceived quality of care affects outpatient satisfaction in China: a cross-sectional study of 136 tertiary hospitals. Inquiry. 2019;56:1-8. https://doi.org/10.1177%2F0046958019895397 PMID: 3188 4866

Downloads

Published

2024-06-24

How to Cite

1.
Chansri P, Poungkaew A, Sriyuktasuth A, Chirakarnjanakorn S. Factors Influencing Adherence to Treatment in Adult Patients with Hypertension. J Thai Nurse midwife Counc [Internet]. 2024 Jun. 24 [cited 2024 Nov. 21];39(02):178-90. Available from: https://he02.tci-thaijo.org/index.php/TJONC/article/view/268032

Issue

Section

Research Articles