Vitamin E: Biochemistry and Clinical Significance
Keywords:
Vitamin E, abetalipoproteinemia, homozygous hypobetalipoproteinemia, ataxia with vitamin E deficiency, hemolytic anemiaAbstract
Vitamin E is a fat-soluble vitamin which is essential for several vital biochemical processes in the human body and usually found in many natural food sources. Vitamin E deficiency is usually accompanied by fat malabsorption syndrome or abnormal vitamin E metabolism. Vitamin E deficiency is rare in adults and could manifest itself in the form of mild anemia and nonspecific neurological symptoms to severe and permanent neurological damage, which leads to irreversible morbidity. Early diagnosis and early treatment of a vitamin E deficiency could prevent the permanent morbidity.
References
Mueller CM, Lord LM, Marian M, McClave SA, Miller SJ, editors. The ASPEN adult nutrition support core curriculum. 3rd ed. Silver Spring: American Society for Parenteral and Enteral Nutrition; 2017.
Bruno RS, Mah E. Vitamin E. Reference module in biomedical sciences. 3rd ed: Elsevier; 2014.
El Hadi H, Vettor R, Rossato M. Vitamin E as a treatment for nonalcoholic fatty liver disease: reality or myth?. Antioxidants (Basel) 2018;7(1):12.
Food and Nutrition Board. Institute of Medicine. Dietary Reference Intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington D.C.: National Academies Press; 2000; p.186-283.
Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr 2007;27(1):347-62.
อุรุวรรณ แย้มบริสุทธิ์. วิตามินอี. ใน: สุปราณี แจ้งบำรุง, ลัดดา เหมาะสุวรรณ, เบ็ญจลักษณ์ ผลรัตน์, อุมาพร สุทัศน์วรวุฒิ, เอมอร อุดมเกษมาลี, นลินี จงวิริยะพันธุ์, และคณะ, บรรณาธิการ. ปริมาณสารอาหารอ้างอิงที่ควรได้รับประจำวันสำหรับคนไทย. กรุงเทพฯ: ห้างหุ้นส่วนจำกัด เอ.วี. โปรเกรสซีฟ; 2563. หน้า157-65.
Gropper SAS, Smith JL, Groff JL. Advanced nutrition and human metabolism. 5th ed. Australia: Wadsworth/Cengage Learning; 2009.
Bruno RS, Leonard SW, Park SI, Zhao Y, Traber MG. Human vitamin E requirements assessed with the use of apples fortified with deuterium-labeled alpha-tocopheryl acetate. Am J Clin Nutr 2006;83(2):299-304.
Schmölz L, Birringer M, Lorkowski S, Wallert M. Complexity of vitamin E metabolism. World J Biol Chem 2016;7(1):14-43.
Pang J, Kiyosawa M, Seko Y, Yokota T, Harino S, Suzuki J. Clinicopathological report of retinitis pigmentosa with vitamin E deficiency caused by mutation of the alpha-tocopherol transfer protein gene. Jpn J Ophthalmol 2001;45(6):672-6.
Leonard SW, Terasawa Y, Farese RV, Jr., Traber MG. Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice. Am J Clin Nutr 2002;75(3):555-60.
Burton GW, Traber MG, Acuff RV, Walters DN, Kayden H, Hughes L, et al. Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr 1998;67(4):669-84.
Bruno RS, Leonard SW, Atkinson J, Montine TJ, Ramakrishnan R, Bray TM, et al. Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med 2006;40(4):689-97.
Pearson P, Lewis SA, Britton J, Young IS, Fogarty A. The pro-oxidant activity of high-dose vitamin E supplements in vivo. BioDrugs 2006;20(5):271-3.
Weinberg RB, VanderWerken BS, Anderson RA, Stegner JE, Thomas MJ. Pro-oxidant effect of vitamin E in cigarette smokers consuming a high polyunsaturated fat diet. Arterioscler Thromb Vasc Biol 2001;21(6):1029-33.
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010;362(18):1675-85.
Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology 2018;67(1):328-57.
Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328(20):1450-6.
Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993;328(20):1444-9.
Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996;347(9004):781-6.
Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 2003;361(9374):2017-23.
Eidelman RS, Hollar D, Hebert PR, Lamas GA, Hennekens CH. Randomized trials of vitamin E in the treatment and prevention of cardiovascular disease. Arch Intern Med 2004;164(14):1552-6.
Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142(1):37-46.
Kumar N. Neurologic presentations of nutritional deficiencies. Neurol Clin 2010;28(1):107-70.
Gwathmey KG, Grogan J. Nutritional neuropathies. Muscle Nerve 2020;62(1):13-29.
Hammond N, Wang Y, Dimachkie MM, Barohn RJ. Nutritional neuropathies. Neurol Clin 2013;31(2):477-89.
Miller KL, Trifan G, Testai FD. Neurology of nutritional deficiencies. Curr Neurol Neurosci Rep 2019;19(12):101.
Rachmilewitz EA, Kornberg A, Acker M. Vitamin E deficiency due to increased consumption in beta-thalassemia and in Gaucher's disease. Ann N Y Acad Sci 1982;393:336-47.
Hentati F, El-Euch G, Bouhlal Y, Amouri R. Ataxia with vitamin E deficiency and abetalipoproteinemia. Handb Clin Neurol 2012;103:295-305.
Berciano J, García A, Infante J. Peripheral nerve involvement in hereditary cerebellar and multisystem degenerative disorders. Handb Clin Neurol 2013;115:907-32.
Lee J, Hegele RA. Abetalipoproteinemia and homozygous hypobetalipoproteinemia: a framework for diagnosis and management. J Inherit Metab Dis 2014;37(3):333-9.
Schuelke M. Ataxia with vitamin E deficiency. In: Adam MP, Ardinger HH, Pagon RA, editors. GeneReviews®[Internet]. 2005 [Updated 2016 Oct 13] [cited 2022 Jan 1]:1993-2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1241/
Wilfond BS, Farrell PM, Laxova A, Mischler E. Severe hemolytic anemia associated with vitamin E deficiency in infants with cystic fibrosis. Implications for neonatal screening. Clin Pediatr (Phila) 1994;33(1):2-7.
Evans HM, Burr GO. The anti-sterility vitamine fat soluble E. Proc Natl Acad Sci U S A 1925;11(6):334-41.
Traber MG, Rader D, Acuff RV, Brewer HB, Jr., Kayden HJ. Discrimination between RRR- and all-racemic-alpha-tocopherols labeled with deuterium by patients with abetalipoproteinemia. Atherosclerosis 1994;108(1):27-37.
Mechanick JI, Apovian C, Brethauer S, Garvey WT, Joffe AM, Kim J. Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures - 2019 update: cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, The Obesity Society, American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists. Surg Obes Relat Dis 2020;16(2):175-247.
Welty FK. Hypobetalipoproteinemia and abetalipoproteinemia. Curr Opin Lipidol 2014;25(3):161-8.
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330(15):1029-35.
Schürks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ 2010;341:c5702.
Abner EL, Schmitt FA, Mendiondo MS, Marcum JL, Kryscio RJ. Vitamin E and all-cause mortality: a meta-analysis. Curr Aging Sci 2011;4(2):158-70.
Klein EA, Thompson IM, Jr., Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, et al. Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2011;306(14):1549-56.
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