ภาวะไข้และเม็ดเลือดต่ำในผู้ป่วยเด็กโรคมะเร็งของโรงพยาบาลราชบุรี

บทคัดย่อ

Objectives : To identify incidence of septicemia and other infections, causative organisms, antibiotics and the results of empirical treatment.

Materials and Method : A retrospective descriptive study in children of cancer patients with febrile neutropenia who admitted in division of pediatrics , Ratchaburi hospital from 1 June 2009 to 31 May 2010.

Results : There were 10 chidren with 19 episodes of febrile neutropenia during the study period. The mean age was 6.83 ± 3.14 years. The incidence of septicemia was 6 episodes (31.6%). Causes of septicemia were gram negative bacteria, P. aeruginosa 2 episodes and E coli 1 episode and gram positive bacteria those were gram positive bacilli, Staph. epidermidis and Streptococcus species 1 episode each. The incidence of urinary tract infection (UTI) was 5 episodes (26.3%). Most organisms caused of UTI were E. coli (40%). The incidence of positive bacterial stool culture was 1 episode (5.3%). The most common empirical antimicrobial agents were ceftazidime and amikacin (68.4%). The response rate was 58.3%.

Conclusion : From this study, we found that incidence of septicemia in children of cancer patients with febrile neutropenia was 31%, most common cause of septicemia was gram negative bacteria. Empirical treatment with ceftazidime and amikacin were still appropriated antibiotics for febrile neutropenic children of cancer patients at Ratchaburi hospital.