Large Core Needle Biopsy: ในการตรวจวินิจฉัยมะเร็งเต้านมที่คลำก้อนได้

บทคัดย่อ

          Objective:  To evaluate LCNB sensitivity, specificity and accuracy in the diagnosis of palpable breast carcinoma, and to value LCNB as an alternative to open surgical biopsy diagnostic procedure. Setting. Nakhonpathom Hospital.

          Subjects and Methods:  Eighty-seven females with palpable breast masses were examined from 1991-2002.The average diameter of the breast masses was 3.8 cm., ranging from 1.5·8.0 cm. Eighty-nine LCNBs with tru-cut needle N0.14 have been performed. Two cr three tissue samples were adequate for pathologic sections. Benign Iesions were proved by excisions. Malignant lesions were subjected to mastectomies. Some malignant cases who denied surgery were followed and found to have distant metastases eventually.

          Results:  Sixty-four cases (77%) of breast carcinomas and 19 (23%) of benign cases were diagnosed. One case had a contralateral metachronous carcinoma after 1.2 yrs. One case had carcinoma in one side and a benign lesion in the other side at the same time. Four cases were excIuded.The average age of the carcinoma group was 57 yrs. No inadequate samplings were recorded. The sensitivity, specificity and accuracy of LCNB were 90%, 100%, 93% respectively. No major complications were found. The patients could perform normal activities on the following day. Furthermore LCNB allows savings of cost and time compared to OSB.

          Conclusions:  LCNB has high accuracy in the diagnosis of breast carcinoma and saves patients' time and cost, surgeons’ time, and hospitaIs’ expense. LCNB should be considerd as an alternative to OSB diagnostic procedure.