Effect of Conventional Therapy on the Development and Progression of Complications in Noninsulin Dependent Diabetes Mellitus (NIDDM)

บทคัดย่อ

There are accelerated macrovascular and microvascular complications in patients with NIDDM. I examined whether conventional therapy with the goal of maintaining blood glucose concen-trations close to the normal range (< 160 mg/dl) could decrease the frequency and severity of these complications.

A total of 767 patients with NIDDM were followed for less than 5 years, between 5 and 10 years, and more than 10 years, and the appearance and progression of complications were assessed regularly. Good blood glucose control reduced the progression of PVD, nephropathy, PDR, and neuropathy, but increased CHD and CVD (P < 0.05 only over 10 years follow-up with CHD). This increased risk should be avoided by keeping preprandial blood glucose above 120 mg/dl especially in patients of old age group.