การศึกษาเปรียบเทียบการใช้ยาด็อกซีซัยคลินขนาดต่างกัน ในการรักษาผู้ป่วยอุจจาระร่วงอย่างแรง ในโรงพยาบาลสมุทรสาคร

บทคัดย่อ

          A comparative trial of a single oral-dose 300 mg. or 200 mg. of doxycycline with the standard multiple doses of every six-hour, 3-consecutive-days of 500 mg. tetracycline was conducted in Samut Sakhon Hospital from March 1 to June 10. 1993. Sixty six in-patients, 34 males and 32 females, 77.3 % of age group 15-40 years, major occupation : employee and construction workers were recruited. Eligibility criteria were 1) symptom of watery stool with moderate to severe dehydration 2) rectal swab positive for Vibrio cholerae O1, Eltor biotype. Patients were randomly allocated to receive either one regimen. The study revealed that those who received doxycycline had more episode of nausea and vomiting and the duration of diarrhea was longer than those who received tetracycline. The duration of Vibrio cholerae excretion between 300 mg. of doxycycline and tetracycline was not significantly different but 200 mg. of doxycycline group had longer period of excretion of Vibrio. It is recommended that 300 mg. of doxycycline be used in outbreak of cholera because of more convenience , economical application and more compliance.