Incident of Contrast-Induced Nephropathy After Receiving Low Osmolar Contrast Media for Computed Tomography in Phrachomklao Petchaburi Hospital

Abstract

Objective: The study is to determine the relationship of the serum creatinine in patients administrated intravenous low osmolar contrast during computed tomography scans in Phrachomklao Petchaburi Hospital and to identify the incidence of contrast induced nephropathy in patients with NCDs, classified by the number of diseases and average change of the serum creatinine level. The aim is to improved efficiency of patient preparation protocols before intravenous contrast administration.

Methods: This descriptive cross-sectional study collected retrospective data from August 2023 to May 2024. The sample included outpatients undergoing computed tomography scans with intravenous low osmolar contrast media. Blood creatinine levels were measured before and after contrast administration, and statistical relationships were analyzed using descriptive statistics and inferential statistic, including chi-square, ANOVA, and Fischer exact test.

Results: The incidence of post contrast induced nephropathy after contrast administration was 0.6% among the 155 patients. There was no statistically significant relationship between changes in creatinine levels among patients with and without NCDs (p = .293). The average changes in blood creatinine levels post-contrast administration also showed no significant relationship between patients with and without NCDs (p = 1.12), with value decreasing between 0.07–1.14 mg/dL.

Conclusion: The use of low osmolar contrast media can be confidently utilized with a low incidence of post contrast induced nephropathy, provided patients are well-prepared with normal saline to prevent renal failure, especially in groups with more than four NCDs or those older than 70 years.