Survival rate of endometrial cancer patients at Phramongkutklao Hospital

Abstract

Objective: To determine the five-year overall survival rate of patients with endometrial cancer after complete treatment at Phramongkutklao hospital.

Materials and Method: This was a retrospective descriptive study. A total of 54 patients were enrolled with histologically confirmed diagnosis of endometrial cancer and that had complete treatment from January 1, 2009 to December 31, 2010 at Phramongkutklao hospital. Overall survival was estimated according to the Kaplan-Meier method and univariate analysis employed Log-rank test to compare between groups.

Main outcome measure: The five-year overall survival rate of patients with endometrial cancer.

Results: The mean age of the 54 patients was 60 ± 10.6 years. All presented symptoms of abnormal uterine bleeding. The majority had early stage disease (66.7%), histopathology cell types were endometrioid carcinoma (90.6%). The majority of adjuvant therapies in advanced stage was chemotherapy plus radiotherapy (27.7%), and early stage was radiotherapy alone (33.4%). The five-year overall survival rate of endometrial cancer was 80.1% that depend on stage were 91.6% in early stage (FIGO stage I-II) and 50% in advanced stage (FIGO stage III-IV). The statistically significant variables affecting overall survival included stage, tumor grade, cervical invasion, lymph nodes metastasis, positive peritoneal cytology and post operative residual tumor more than 2 cm.

Conclusion: The five-year overall survival rate of endometrial cancer was 80.1%. The FIGO stage and tumor grade were correlated with overall survival of patients with endometrial cancer.