The relationship between CD4 level and adverse reaction to antituberculosis drugs in HIV patients in Saraphee hospital

Abstract

            The objective of this research was to evaluate the relationship between the CD4 level and adverse reaction to antituberculosis drugs by using the prospective data collected from 23 HIV patients who were not treated by antiretrovirus or HIV related drugs, in the HIV and tuberculosis clinic at Saraphee hospital during October 1 2005 to July 1 2007. The patients were categorized into 15 males and 8 females, aged from 20 to 70 years old with 8 to 273 cells of CD4 level. All were under 2HRZE+4HR standard treatment according to national tuberculosis treatment and follow up standard programs of Thailand. From the study, it was found that only one female suspected tuberculosis patient with 273 cells of CD4 level had urticarial and no fever after taking antituberculosis drugs. The symptom was disappeared with in one week after being treated with antihistamine drug. The results indicate that there is no relationship between the CD4 level and adverse reaction to antituberculosis drugs in AIDS patients.