Compare efficacy of intramuscular diclofenac sodium with morphine in the treatment of post cesarean section pain
Keywords:
การผ่าตัดคลอด, Diclofenac, Morphine, ระดับความเจ็บปวดAbstract
Objective: To compare the efficacy of intramuscular diclofenac sodium with morphine in the treatment of post cesarean section pain Study Design: A double blind randomized controlled trial Setting: Department of Obstetrics and Gynecology, Lamphun Hospital, Lamphun Subjects: Two hundred post cesarean women in Lamphun Hospital from December 1st 2004 to June 15th 2006. Intervention: The subjects were randomized by allocation to receive Intramuscular diclofenac sodium 75 mg (n=81) or intramuscular morphine 10 mg (n=74) and 45 cases were excluded. Level of pain using visual analog score were evaluated (pre, post received diclofenac or morphine and Level of decreased pain) Main outcome measure: Level of decreased pain in post cesarean women between diclofenac group and morphine group using visual analog score. Results: The level of pain (pre-received diclofenac or morphine (P=0.250), post received diclofenac or morphine (P=0.122) were bit significantly different but level of decreased pain were significantly difference (P=0.018) between diclofenac group and morphine group. Diclofenac could decreased the level of pain better than morphine. Conclusion: Efficacy of intramuscular diclofenac sodium compared with intramuscular morphine in the treatment of post cesarean section pain were significantly different. Diclofenac could decreased the level of pain better than morphine.
References
Robieux I, koren G, Vandenbergh H, Schneidermen J. Morphine excretion in breast milk and resultant exposure of a nursing infant. J Toxicol Clin Toxicol 199.; 28: 365-70.
Gerald G, Roger K, Sumner J. Morphine. Drug in pregnancy and lactation 2002; 2:957-9
Goldsmith DP. Neonatal rheumatic disorders. View of the pediatrician. Rheum Dis Clin North Am 1989; 15: 287-305.
Needs CJ. Brooks PM. Antirheumatic medication during lactation. Br J Rheumatol 1985; 24: 291-7.
Product information. Voltaren. Geigy Pharmaceuticals, 1995.
Anderson PO. Medication use while breast feeding a neonate. Neonatal Pharmacol Q 1993; 2: 3-14.
Athicom Bourlert. Diclofenac Intramuscular single dose to decrease pain in post operative cesarean section. J Med Assoc Thai 2005; 88(1): 15-9.
Dubai Efficacy and safety of repeated post operative admistratio of intramuscular diclofenac sodium in the treatment of postcesarean section pain. Arch Med Res.2001 Mar-Apr; 32(2): 148-54.
บัญชีราคายา. กลุ่มงานเภสัชกรรมโรงพยาบาลลำพูน. ประจำเดือนกรกฎาคม – กันยายน 2547.
